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- Aminooxyacetic_acid abstract "Aminooxyacetic acid, often abbreviated AOA or AOAA, is a compound that inhibits 4-aminobutyrate aminotransferase (GABA-T) activity in vitro and in vivo, leading to less gamma-aminobutyric acid (GABA) being broken down. Subsequently, the level of GABA is increased in tissues. At concentrations high enough to fully inhibit 4-aminobutyrate aminotransferase activity, aminooxyacetic acid is indicated as a useful tool to study regional GABA turnover in rats.Aminooxyacetic acid is a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T). It functions as an inhibitor by attacking the Schiff base linkage between PLP and the enzyme, forming oxime type complexes.Aminooxyacetic acid inhibits aspartate aminotransferase, another PLP-dependent enzyme, which is an essential part of the malate-aspartate shuttle. The inhibition of the malate-aspartate shuttle prevents the reoxidation of cytosolic NADH by the mitochondria in nerve terminals. Also in the nerve terminals, aminooxyacetic acid prevents the mitochondria from utilizing pyruvate generated from glycolysis, thus leading to a bioenergetic state similar to that of hypoglycemia. Aminooxyacetic acid has been shown to cause excitotoxic lesions of the striatum, similar to Huntington's disease, potentially due to its impairment of mitochondrial energy metabolism. Aminooxyacetic acid was previously used in a clinical trial to reduce symptoms of Huntington's disease by increasing GABA levels in the brain. However, the patients who received the aminooxyacetic acid treatment failed to show clinical improvement and suffered from side effects such as drowsiness, ataxia, seizures, and psychotic behavior when the dosage was increased beyond 2 mg per kilogram per day. Also, the inhibition of aspartate aminotransferase by aminooxyacetic acid has clinical implications for the treatment of breast cancer, since a decrease in glycolysis disrupts breast adenocarcinoma cells more than normal cells.Aminooxyacetic acid has been studied as a treatment for tinnitus. One study showed that about 20% of patients with tinnitus had a decrease in its severity when treated with aminooxyacetic acid. However, about 70% of those patients reported side effects, mostly nausea and disequilibrium. Thus, the investigators of the study concluded that the incidence of the side effects makes aminooxyacetic acid unsuitable to treat tinnitus.Aminooxyacetic acid also has anticonvulsant properties. At high dosages, it can act as a convulsant agent in mice and rats.Aminooxyacetic acid can also inhibit 1-aminocyclopropane-1-carboxylate synthase preventing ethylene synthesis, which can increase the vase life of cut flowers.".
- Aminooxyacetic_acid iupacName "2-(aminooxy)acetic acid".
- Aminooxyacetic_acid thumbnail Aminooxyacetic_Acid.svg?width=300.
- Aminooxyacetic_acid wikiPageID "31818700".
- Aminooxyacetic_acid wikiPageLength "12364".
- Aminooxyacetic_acid wikiPageOutDegree "44".
- Aminooxyacetic_acid wikiPageRevisionID "678459147".
- Aminooxyacetic_acid wikiPageWikiLink 1-aminocyclopropane-1-carboxylate_synthase.
- Aminooxyacetic_acid wikiPageWikiLink 4-aminobutyrate_transaminase.
- Aminooxyacetic_acid wikiPageWikiLink Adenocarcinoma.
- Aminooxyacetic_acid wikiPageWikiLink Alfred_Werner.
- Aminooxyacetic_acid wikiPageWikiLink Anticonvulsant.
- Aminooxyacetic_acid wikiPageWikiLink Aspartate_aminotransferase.
- Aminooxyacetic_acid wikiPageWikiLink Aspartate_transaminase.
- Aminooxyacetic_acid wikiPageWikiLink Ataxia.
- Aminooxyacetic_acid wikiPageWikiLink Bioenergetics.
- Aminooxyacetic_acid wikiPageWikiLink Breast_cancer.
- Aminooxyacetic_acid wikiPageWikiLink Category:GABA_transaminase_inhibitors.
- Aminooxyacetic_acid wikiPageWikiLink Category:Glutamate_decarboxylase_inhibitors.
- Aminooxyacetic_acid wikiPageWikiLink Convulsant.
- Aminooxyacetic_acid wikiPageWikiLink Disequilibrium_(medicine).
- Aminooxyacetic_acid wikiPageWikiLink Drowsiness.
- Aminooxyacetic_acid wikiPageWikiLink Enzyme.
- Aminooxyacetic_acid wikiPageWikiLink Epileptic_seizure.
- Aminooxyacetic_acid wikiPageWikiLink Ethyl_bromoacetate.
- Aminooxyacetic_acid wikiPageWikiLink Ethylene.
- Aminooxyacetic_acid wikiPageWikiLink Excitotoxicity.
- Aminooxyacetic_acid wikiPageWikiLink Gamma-Aminobutyric_acid.
- Aminooxyacetic_acid wikiPageWikiLink Glycolysis.
- Aminooxyacetic_acid wikiPageWikiLink Huntingtons_disease.
- Aminooxyacetic_acid wikiPageWikiLink Hydrochloric_acid.
- Aminooxyacetic_acid wikiPageWikiLink Hypoglycemia.
- Aminooxyacetic_acid wikiPageWikiLink In_vitro.
- Aminooxyacetic_acid wikiPageWikiLink In_vivo.
- Aminooxyacetic_acid wikiPageWikiLink Ketone.
- Aminooxyacetic_acid wikiPageWikiLink Laboratory_rat.
- Aminooxyacetic_acid wikiPageWikiLink Lesion.
- Aminooxyacetic_acid wikiPageWikiLink Malate-aspartate_shuttle.
- Aminooxyacetic_acid wikiPageWikiLink Mitochondrion.
- Aminooxyacetic_acid wikiPageWikiLink Nausea.
- Aminooxyacetic_acid wikiPageWikiLink Nicotinamide_adenine_dinucleotide.
- Aminooxyacetic_acid wikiPageWikiLink Oxime.
- Aminooxyacetic_acid wikiPageWikiLink Psychosis.
- Aminooxyacetic_acid wikiPageWikiLink Pyridoxal_phosphate.
- Aminooxyacetic_acid wikiPageWikiLink Pyruvate.
- Aminooxyacetic_acid wikiPageWikiLink Pyruvic_acid.
- Aminooxyacetic_acid wikiPageWikiLink Rudolph_Schoenheimer.
- Aminooxyacetic_acid wikiPageWikiLink Schiff_base.
- Aminooxyacetic_acid wikiPageWikiLink Seizure.
- Aminooxyacetic_acid wikiPageWikiLink Side_effect.
- Aminooxyacetic_acid wikiPageWikiLink Somnolence.
- Aminooxyacetic_acid wikiPageWikiLink Striatum.
- Aminooxyacetic_acid wikiPageWikiLink Tinnitus.
- Aminooxyacetic_acid wikiPageWikiLink Tissue_(biology).
- Aminooxyacetic_acid wikiPageWikiLink Vase_life.
- Aminooxyacetic_acid wikiPageWikiLinkText "Aminooxyacetic acid".
- Aminooxyacetic_acid wikiPageWikiLinkText "aminooxyacetic acid".
- Aminooxyacetic_acid hasPhotoCollection Aminooxyacetic_acid.
- Aminooxyacetic_acid imagefile "Aminooxyacetic Acid.svg".
- Aminooxyacetic_acid iupacname "2".
- Aminooxyacetic_acid othernames "Carboxymethoxylamine".
- Aminooxyacetic_acid othernames "Hydroxylamineacetic acid".
- Aminooxyacetic_acid othernames "U-7524".
- Aminooxyacetic_acid verifiedfields "changed".
- Aminooxyacetic_acid watchedfields "changed".
- Aminooxyacetic_acid wikiPageUsesTemplate Template:Chembox.
- Aminooxyacetic_acid wikiPageUsesTemplate Template:GABAergics.
- Aminooxyacetic_acid wikiPageUsesTemplate Template:Glutamatergics.
- Aminooxyacetic_acid wikiPageUsesTemplate Template:Reflist.
- Aminooxyacetic_acid subject Category:GABA_transaminase_inhibitors.
- Aminooxyacetic_acid subject Category:Glutamate_decarboxylase_inhibitors.
- Aminooxyacetic_acid hypernym Compound.
- Aminooxyacetic_acid type Article.
- Aminooxyacetic_acid type ChemicalCompound.
- Aminooxyacetic_acid type ChemicalSubstance.
- Aminooxyacetic_acid type Article.
- Aminooxyacetic_acid type Inhibitor.
- Aminooxyacetic_acid type ChemicalObject.
- Aminooxyacetic_acid type Thing.
- Aminooxyacetic_acid type Q11173.
- Aminooxyacetic_acid comment "Aminooxyacetic acid, often abbreviated AOA or AOAA, is a compound that inhibits 4-aminobutyrate aminotransferase (GABA-T) activity in vitro and in vivo, leading to less gamma-aminobutyric acid (GABA) being broken down. Subsequently, the level of GABA is increased in tissues.".
- Aminooxyacetic_acid label "Aminooxyacetic acid".
- Aminooxyacetic_acid sameAs آمینواکسیاستیک_اسید.
- Aminooxyacetic_acid sameAs m.0gttz_n.
- Aminooxyacetic_acid sameAs Aminooksisirćetna_kiselina.
- Aminooxyacetic_acid sameAs Aminooksisirćetna_kiselina.
- Aminooxyacetic_acid sameAs Q4746466.
- Aminooxyacetic_acid sameAs Q4746466.
- Aminooxyacetic_acid wasDerivedFrom Aminooxyacetic_acid?oldid=678459147.
- Aminooxyacetic_acid depiction Aminooxyacetic_Acid.svg.
- Aminooxyacetic_acid isPrimaryTopicOf Aminooxyacetic_acid.