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- Aminolevulinic_acid_synthase abstract "ALA synthase (EC 2.3.1.37), or ALAS, catalyzes the synthesis of D-Aminolevulinic acid (ALA) the first common precursor in the biosynthesis of all tetrapyrroles such as hemes, cobalamins and chlorophylls. The enzyme is expressed in all non-plant eukaryotes and the α-class of proteobacteria. Other organisms produce ALA through a three enzyme pathway known as the Shemin pathway. ALA is synthesized through the condensation of glycine and succinyl-CoA. In humans, transcription of ALA synthase is tightly controlled by the presence of Fe2+-binding elements, to prevent accumulation of porphyrin intermediates in the absence of iron. There are two forms of ALA synthase in the body. One form is expressed in red blood cell precursor cells (ALAS2), whereas the other (ALAS1) is ubiquitously expressed throughout the body. The red blood cell form is coded by a gene on chromosome x, whereas the other form is coded by a gene on chromosome 3. The disease X-linked sideroblastic anemia is caused by mutations in the ALA synthase gene on chromosome X, whereas no diseases are known to be caused by mutations in the other gene. Gain of function mutations in the erythroid specific ALA synthase gene have been shown recently to cause a previously unknown form of porphyria known as X-linked-dominant protoporphyria.".
- Aminolevulinic_acid_synthase thumbnail ALAS_Reaction_Mechanism_Image.jpg?width=300.
- Aminolevulinic_acid_synthase wikiPageExternalLink gene=alas1.
- Aminolevulinic_acid_synthase wikiPageExternalLink sideroblastic.html.
- Aminolevulinic_acid_synthase wikiPageID "782554".
- Aminolevulinic_acid_synthase wikiPageLength "9314".
- Aminolevulinic_acid_synthase wikiPageOutDegree "20".
- Aminolevulinic_acid_synthase wikiPageRevisionID "679076930".
- Aminolevulinic_acid_synthase wikiPageWikiLink ALAS1.
- Aminolevulinic_acid_synthase wikiPageWikiLink ALAS2.
- Aminolevulinic_acid_synthase wikiPageWikiLink Amine.
- Aminolevulinic_acid_synthase wikiPageWikiLink Amino.
- Aminolevulinic_acid_synthase wikiPageWikiLink Aminolevulinic_acid.
- Aminolevulinic_acid_synthase wikiPageWikiLink Carboxyl.
- Aminolevulinic_acid_synthase wikiPageWikiLink Carboxylic_acid.
- Aminolevulinic_acid_synthase wikiPageWikiLink Category:EC_2.3.1.
- Aminolevulinic_acid_synthase wikiPageWikiLink Coenzyme_A.
- Aminolevulinic_acid_synthase wikiPageWikiLink D-Aminolevulinic_acid.
- Aminolevulinic_acid_synthase wikiPageWikiLink Glucose.
- Aminolevulinic_acid_synthase wikiPageWikiLink Glycine.
- Aminolevulinic_acid_synthase wikiPageWikiLink Hemin.
- Aminolevulinic_acid_synthase wikiPageWikiLink Iron.
- Aminolevulinic_acid_synthase wikiPageWikiLink Pyridinium.
- Aminolevulinic_acid_synthase wikiPageWikiLink Pyridoxal_phosphate.
- Aminolevulinic_acid_synthase wikiPageWikiLink Sideroblastic_anemia.
- Aminolevulinic_acid_synthase wikiPageWikiLink Succinyl-CoA.
- Aminolevulinic_acid_synthase wikiPageWikiLink Tetrapyrrole.
- Aminolevulinic_acid_synthase wikiPageWikiLink Tetrapyrroles.
- Aminolevulinic_acid_synthase wikiPageWikiLink File:ALAS_Reaction_Mechanism_Image.jpg.
- Aminolevulinic_acid_synthase wikiPageWikiLink File:Heme_synth_step1.png.
- Aminolevulinic_acid_synthase wikiPageWikiLink File:Heme_synthesis.png.
- Aminolevulinic_acid_synthase wikiPageWikiLinkText "ALA synthase".
- Aminolevulinic_acid_synthase wikiPageWikiLinkText "ALAS".
- Aminolevulinic_acid_synthase wikiPageWikiLinkText "Aminolevulinic acid synthase".
- Aminolevulinic_acid_synthase wikiPageWikiLinkText "aminolevulinic acid synthase".
- Aminolevulinic_acid_synthase hasPhotoCollection Aminolevulinic_acid_synthase.
- Aminolevulinic_acid_synthase wikiPageUsesTemplate Template:Acyltransferases.
- Aminolevulinic_acid_synthase wikiPageUsesTemplate Template:Cite_journal.
- Aminolevulinic_acid_synthase wikiPageUsesTemplate Template:EC_number.
- Aminolevulinic_acid_synthase wikiPageUsesTemplate Template:Porphyrin_biosynthesis_enzymes.
- Aminolevulinic_acid_synthase wikiPageUsesTemplate Template:Reflist.
- Aminolevulinic_acid_synthase subject Category:EC_2.3.1.
- Aminolevulinic_acid_synthase comment "ALA synthase (EC 2.3.1.37), or ALAS, catalyzes the synthesis of D-Aminolevulinic acid (ALA) the first common precursor in the biosynthesis of all tetrapyrroles such as hemes, cobalamins and chlorophylls. The enzyme is expressed in all non-plant eukaryotes and the α-class of proteobacteria. Other organisms produce ALA through a three enzyme pathway known as the Shemin pathway. ALA is synthesized through the condensation of glycine and succinyl-CoA.".
- Aminolevulinic_acid_synthase label "Aminolevulinic acid synthase".
- Aminolevulinic_acid_synthase sameAs أمينوليفولينيك_أسيد_سينثاز.
- Aminolevulinic_acid_synthase sameAs Δ-Aminolävulinatsynthase.
- Aminolevulinic_acid_synthase sameAs Ácido_aminolevulínico_sintasa.
- Aminolevulinic_acid_synthase sameAs Aminolevulinaattisyntaasi.
- Aminolevulinic_acid_synthase sameAs Acide_aminolévulinique_synthase.
- Aminolevulinic_acid_synthase sameAs 5-amminolevulinato_sintasi.
- Aminolevulinic_acid_synthase sameAs アミノレブリン酸シンターゼ.
- Aminolevulinic_acid_synthase sameAs ALA_synthase.
- Aminolevulinic_acid_synthase sameAs Syntaza_ALA.
- Aminolevulinic_acid_synthase sameAs m.03b_6n.
- Aminolevulinic_acid_synthase sameAs 5-Aminolevulinat_sintaza.
- Aminolevulinic_acid_synthase sameAs 5-Aminolevulinat_sintaza.
- Aminolevulinic_acid_synthase sameAs Q286049.
- Aminolevulinic_acid_synthase sameAs Q286049.
- Aminolevulinic_acid_synthase wasDerivedFrom Aminolevulinic_acid_synthase?oldid=679076930.
- Aminolevulinic_acid_synthase depiction ALAS_Reaction_Mechanism_Image.jpg.
- Aminolevulinic_acid_synthase isPrimaryTopicOf Aminolevulinic_acid_synthase.