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- Aminoglycoside-3-phosphotransferase abstract "Aminoglycoside-3'-phosphotrasnsferase (APH(3')), also known as aminoglycoside kinase, is an enzyme that primarily catalyzes the addition of phosphate from ATP to the 3'-hydroxyl group of a 4,6-disubstituted aminoglycoside, such as kanamycin. However, APH(3') has also been found to phosphorylate at the 5'-hydroxyl group in 4,5-disubstituted aminoglycosides, which lack a 3'-hydroxyl group, and to diphosphorylate hydroxyl groups in aminoglycosides that have both 3'- and 5'-hydroxyl groups. Primarily positively charged at biological conditions, aminoglycosides bind to the negatively charged backbone of nucleic acids to disrupt protein synthesis, effectively inhibiting bacterial cell growth. APH(3') mediated phosphorylation of aminoglycosides effectively disrupts their mechanism of action, introducing a phosphate group that reduces their binding affinity due to steric hindrances and unfavorable electrostatic interactions. APH(3') is primarily found in certain species of gram-positive bacteria.".
- Aminoglycoside-3-phosphotransferase ecNumber "2.7.1.95".
- Aminoglycoside-3-phosphotransferase thumbnail APHStructure.png?width=300.
- Aminoglycoside-3-phosphotransferase wikiPageID "45609896".
- Aminoglycoside-3-phosphotransferase wikiPageLength "10942".
- Aminoglycoside-3-phosphotransferase wikiPageOutDegree "39".
- Aminoglycoside-3-phosphotransferase wikiPageRevisionID "676591267".
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Active_site.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Adenosine_triphosphate.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Alpha-helix.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Alpha_helix.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Amino_acid.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Aminoglycoside.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Antiparallel_(biochemistry).
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Beta-sheet.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Beta_sheet.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink C-terminus.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Catalysis.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Category:Enzymes.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Category:Transferases.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Dissociative_substitution.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Disulfide.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Disulfide_bonds.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Enzyme.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Genetic_engineering.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Gram-positive_bacteria.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Hydroxyl.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Kanamycin.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Ligand_(biochemistry).
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Magnesium.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Metaphosphate.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Mutagenesis.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink N-terminus.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Neomycin.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Nucleic_acid.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Nucleic_acids.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Phosphate.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Polymer.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Protein_biosynthesis.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Protein_conformation.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Protein_kinase.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Protein_kinases.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Protein_structure.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Stem-loop.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Steric_effects.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink Vector_(molecular_biology).
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink X-ray_crystallography.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink File:APHActiveSite.png.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink File:APHNegativeBindinPocket.png.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink File:APHReactionMechanism.png.
- Aminoglycoside-3-phosphotransferase wikiPageWikiLink File:APHRxnScheme.png.
- Aminoglycoside-3-phosphotransferase caption "Structure of APH, taken from 1L8T".
- Aminoglycoside-3-phosphotransferase casNumber "60120".
- Aminoglycoside-3-phosphotransferase ecNumber "2.7".
- Aminoglycoside-3-phosphotransferase goCode "46353".
- Aminoglycoside-3-phosphotransferase hasPhotoCollection Aminoglycoside-3-phosphotransferase.
- Aminoglycoside-3-phosphotransferase iubmbEcNumber "2".
- Aminoglycoside-3-phosphotransferase name "Aminoglycoside-3'-Phosphotransferase".
- Aminoglycoside-3-phosphotransferase width "250".
- Aminoglycoside-3-phosphotransferase wikiPageUsesTemplate Template:Enzyme.
- Aminoglycoside-3-phosphotransferase subject Category:Enzymes.
- Aminoglycoside-3-phosphotransferase subject Category:Transferases.
- Aminoglycoside-3-phosphotransferase hypernym Enzyme.
- Aminoglycoside-3-phosphotransferase type Biomolecule.
- Aminoglycoside-3-phosphotransferase type Enzyme.
- Aminoglycoside-3-phosphotransferase type Protein.
- Aminoglycoside-3-phosphotransferase type Thing.
- Aminoglycoside-3-phosphotransferase type Q206229.
- Aminoglycoside-3-phosphotransferase type Q8047.
- Aminoglycoside-3-phosphotransferase comment "Aminoglycoside-3'-phosphotrasnsferase (APH(3')), also known as aminoglycoside kinase, is an enzyme that primarily catalyzes the addition of phosphate from ATP to the 3'-hydroxyl group of a 4,6-disubstituted aminoglycoside, such as kanamycin. However, APH(3') has also been found to phosphorylate at the 5'-hydroxyl group in 4,5-disubstituted aminoglycosides, which lack a 3'-hydroxyl group, and to diphosphorylate hydroxyl groups in aminoglycosides that have both 3'- and 5'-hydroxyl groups.".
- Aminoglycoside-3-phosphotransferase label "Aminoglycoside-3'-phosphotransferase".
- Aminoglycoside-3-phosphotransferase sameAs m.012zr275.
- Aminoglycoside-3-phosphotransferase sameAs Q19903283.
- Aminoglycoside-3-phosphotransferase sameAs Q19903283.
- Aminoglycoside-3-phosphotransferase wasDerivedFrom Aminoglycoside-3-phosphotransferaseoldid=676591267.
- Aminoglycoside-3-phosphotransferase depiction APHStructure.png.
- Aminoglycoside-3-phosphotransferase isPrimaryTopicOf Aminoglycoside-3-phosphotransferase.
- Aminoglycoside-3-phosphotransferase name "Aminoglycoside-3'-Phosphotransferase".