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- Alpha_amylase_inhibitor abstract "In molecular biology, alpha-amylase inhibitor is a protein family which inhibits mammalian alpha-amylases specifically, by forming a tight stoichiometric 1:1 complex with alpha-amylase. This family of inhibitors has no action on plant and microbial alpha amylases.A crystal structure has been determined for tendamistat, the 74-amino acid inhibitor produced by Streptomyces tendae that targets a wide range of mammalian alpha-amylases. The binding of tendamistat to alpha-amylase leads to the steric blockage of the active site of the enzyme. The crystal structure of tendamistat revealed an immunoglobulin-like fold that could potentially adopt multiple conformations. Such molecular flexibility could enable an induced-fit type of binding that would both optimise binding and allow broad target specificity.".
- Alpha_amylase_inhibitor symbol "A_amylase_inhib".
- Alpha_amylase_inhibitor thumbnail PDB_1hoe_EBI.jpg?width=300.
- Alpha_amylase_inhibitor wikiPageID "32018612".
- Alpha_amylase_inhibitor wikiPageLength "1903".
- Alpha_amylase_inhibitor wikiPageOutDegree "18".
- Alpha_amylase_inhibitor wikiPageRevisionID "590548376".
- Alpha_amylase_inhibitor wikiPageWikiLink Active_site.
- Alpha_amylase_inhibitor wikiPageWikiLink Alpha-amylase.
- Alpha_amylase_inhibitor wikiPageWikiLink Binding_(molecular).
- Alpha_amylase_inhibitor wikiPageWikiLink Biomolecular_structure.
- Alpha_amylase_inhibitor wikiPageWikiLink Category:Protein_domains.
- Alpha_amylase_inhibitor wikiPageWikiLink Chemical_conformation.
- Alpha_amylase_inhibitor wikiPageWikiLink Chemical_structure.
- Alpha_amylase_inhibitor wikiPageWikiLink Crystal_structure.
- Alpha_amylase_inhibitor wikiPageWikiLink Enzyme.
- Alpha_amylase_inhibitor wikiPageWikiLink Enzyme_inhibitor.
- Alpha_amylase_inhibitor wikiPageWikiLink Mammal.
- Alpha_amylase_inhibitor wikiPageWikiLink Mammalia.
- Alpha_amylase_inhibitor wikiPageWikiLink Mammalian.
- Alpha_amylase_inhibitor wikiPageWikiLink Microbe.
- Alpha_amylase_inhibitor wikiPageWikiLink Microorganism.
- Alpha_amylase_inhibitor wikiPageWikiLink Molecular_binding.
- Alpha_amylase_inhibitor wikiPageWikiLink Multiprotein_complex.
- Alpha_amylase_inhibitor wikiPageWikiLink Plant.
- Alpha_amylase_inhibitor wikiPageWikiLink Protein_complex.
- Alpha_amylase_inhibitor wikiPageWikiLink Protein_folding.
- Alpha_amylase_inhibitor wikiPageWikiLink Secondary_structure.
- Alpha_amylase_inhibitor wikiPageWikiLink Sensitivity_and_specificity.
- Alpha_amylase_inhibitor wikiPageWikiLink Steric.
- Alpha_amylase_inhibitor wikiPageWikiLink Steric_effects.
- Alpha_amylase_inhibitor wikiPageWikiLinkText "Alpha amylase inhibitor".
- Alpha_amylase_inhibitor wikiPageWikiLinkText "alpha amylase inhibitor".
- Alpha_amylase_inhibitor caption "crystal structure determination, refinement and the molecular model of the alpha-amylase inhibitor hoe-467a".
- Alpha_amylase_inhibitor hasPhotoCollection Alpha_amylase_inhibitor.
- Alpha_amylase_inhibitor interpro "IPR000833".
- Alpha_amylase_inhibitor name "A_amylase_inhib".
- Alpha_amylase_inhibitor pfam "PF01356".
- Alpha_amylase_inhibitor scop "1".
- Alpha_amylase_inhibitor symbol "A_amylase_inhib".
- Alpha_amylase_inhibitor wikiPageUsesTemplate Template:Infobox_protein_family.
- Alpha_amylase_inhibitor wikiPageUsesTemplate Template:InterPro_content.
- Alpha_amylase_inhibitor wikiPageUsesTemplate Template:Reflist.
- Alpha_amylase_inhibitor subject Category:Protein_domains.
- Alpha_amylase_inhibitor hypernym Family.
- Alpha_amylase_inhibitor type Biomolecule.
- Alpha_amylase_inhibitor type Protein.
- Alpha_amylase_inhibitor type Chemical.
- Alpha_amylase_inhibitor type Domain.
- Alpha_amylase_inhibitor type Thing.
- Alpha_amylase_inhibitor type Q206229.
- Alpha_amylase_inhibitor type Q8054.
- Alpha_amylase_inhibitor comment "In molecular biology, alpha-amylase inhibitor is a protein family which inhibits mammalian alpha-amylases specifically, by forming a tight stoichiometric 1:1 complex with alpha-amylase. This family of inhibitors has no action on plant and microbial alpha amylases.A crystal structure has been determined for tendamistat, the 74-amino acid inhibitor produced by Streptomyces tendae that targets a wide range of mammalian alpha-amylases.".
- Alpha_amylase_inhibitor label "Alpha amylase inhibitor".
- Alpha_amylase_inhibitor sameAs m.0gw_lqd.
- Alpha_amylase_inhibitor sameAs Q4735150.
- Alpha_amylase_inhibitor sameAs Q4735150.
- Alpha_amylase_inhibitor wasDerivedFrom Alpha_amylase_inhibitor?oldid=590548376.
- Alpha_amylase_inhibitor depiction PDB_1hoe_EBI.jpg.
- Alpha_amylase_inhibitor isPrimaryTopicOf Alpha_amylase_inhibitor.