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- Allosteric_enzyme abstract "Allosteric enzymes are enzymes that change their conformational ensemble upon binding of an effector, which results in an apparent change in binding affinity at a different ligand binding site. This "action at a distance" through binding of one ligand affecting the binding of another at a distinctly different site, is the essence of the allosteric concept. Allostery plays a crucial role in many fundamental biological processes, including but not limited to cell signaling and the regulation of metabolism. Allosteric enzymes need not be oligomers as previously thought, and in fact many systems have demonstrated allostery within single enzymes.Whereas enzymes without coupled domains/subunits display normal Michaelis-Menten kinetics, most allosteric enzymes have multiple coupled domains/subunits and show cooperative binding. Generally speaking, such cooperativity results in allosteric enzymes displaying a sigmoidal dependence on the concentration of their substrates in positively cooperative systems. This allows most allosteric enzymes to greatly vary catalytic output in response to small changes in effector concentration. Effector molecules, which may be the substrate itself (homotropic effectors) or some other small molecule (heterotropic effector), may cause the enzyme to become more active or less active by redistributing the ensemble between the higher affinity and lower affinity states. The binding sites for heterotropic effectors, called allosteric sites, are usually separate from the active site yet thermodynamically coupled. Allosteric Database (ASD, http://mdl.shsmu.edu.cn/ASD) provides a central resource for the display, search and analysis of the structure, function and related annotation for allosteric molecules, including allosteric enzymes and their modulators. Each enzyme is annotated with detailed description of allostery, biological process and related diseases, and each modulator with binding affinity, physicochemical properties and therapeutic area.".
- Allosteric_enzyme wikiPageExternalLink default.asp?s=&n=&i=&v=&o=&ns=0&uid=0&rau=0.
- Allosteric_enzyme wikiPageExternalLink ASD).
- Allosteric_enzyme wikiPageID "6182049".
- Allosteric_enzyme wikiPageLength "5213".
- Allosteric_enzyme wikiPageOutDegree "34".
- Allosteric_enzyme wikiPageRevisionID "629283908".
- Allosteric_enzyme wikiPageWikiLink Allosteric.
- Allosteric_enzyme wikiPageWikiLink Allosteric_regulation.
- Allosteric_enzyme wikiPageWikiLink Aspartate_carbamoyltransferase.
- Allosteric_enzyme wikiPageWikiLink Binding_site.
- Allosteric_enzyme wikiPageWikiLink Category:Enzymes.
- Allosteric_enzyme wikiPageWikiLink Cell_signaling.
- Allosteric_enzyme wikiPageWikiLink Chemical_structure.
- Allosteric_enzyme wikiPageWikiLink Conformational_change.
- Allosteric_enzyme wikiPageWikiLink Conversion_(chemistry).
- Allosteric_enzyme wikiPageWikiLink Cooperative_binding.
- Allosteric_enzyme wikiPageWikiLink Crystal_structure.
- Allosteric_enzyme wikiPageWikiLink Effector_(biology).
- Allosteric_enzyme wikiPageWikiLink Energy_level.
- Allosteric_enzyme wikiPageWikiLink Energy_state.
- Allosteric_enzyme wikiPageWikiLink Enzyme.
- Allosteric_enzyme wikiPageWikiLink Enzyme_kinetics.
- Allosteric_enzyme wikiPageWikiLink Escherichia_coli.
- Allosteric_enzyme wikiPageWikiLink Hemoglobin.
- Allosteric_enzyme wikiPageWikiLink Jean-Pierre_Changeux.
- Allosteric_enzyme wikiPageWikiLink Max_Perutz.
- Allosteric_enzyme wikiPageWikiLink Metabolism.
- Allosteric_enzyme wikiPageWikiLink Michaelis_menten_equation.
- Allosteric_enzyme wikiPageWikiLink Michaelis–Menten_kinetics.
- Allosteric_enzyme wikiPageWikiLink Protein.
- Allosteric_enzyme wikiPageWikiLink Scientific_modelling.
- Allosteric_enzyme wikiPageWikiLink Sigmoid_function.
- Allosteric_enzyme wikiPageWikiLink Site-directed_mutagenesis.
- Allosteric_enzyme wikiPageWikiLink Small-angle_X-ray_scattering.
- Allosteric_enzyme wikiPageWikiLink Small_angle_x-ray_scattering.
- Allosteric_enzyme wikiPageWikiLink Statistical_mechanics.
- Allosteric_enzyme wikiPageWikiLink Substrate_(biochemistry).
- Allosteric_enzyme wikiPageWikiLink Substrate_(chemistry).
- Allosteric_enzyme wikiPageWikiLink X-ray_crystallography.
- Allosteric_enzyme wikiPageWikiLinkText "Allosteric enzyme".
- Allosteric_enzyme wikiPageWikiLinkText "allosteric communication".
- Allosteric_enzyme wikiPageWikiLinkText "allosteric enzyme".
- Allosteric_enzyme hasPhotoCollection Allosteric_enzyme.
- Allosteric_enzyme wikiPageUsesTemplate Template:Reflist.
- Allosteric_enzyme subject Category:Enzymes.
- Allosteric_enzyme hypernym Enzymes.
- Allosteric_enzyme type Biomolecule.
- Allosteric_enzyme comment "Allosteric enzymes are enzymes that change their conformational ensemble upon binding of an effector, which results in an apparent change in binding affinity at a different ligand binding site. This "action at a distance" through binding of one ligand affecting the binding of another at a distinctly different site, is the essence of the allosteric concept.".
- Allosteric_enzyme label "Allosteric enzyme".
- Allosteric_enzyme sameAs Алостерични_ензими.
- Allosteric_enzyme sameAs Enzima_alostérica.
- Allosteric_enzyme sameAs Entzima_alosteriko.
- Allosteric_enzyme sameAs Encima_alostérico.
- Allosteric_enzyme sameAs m.0fvj2d.
- Allosteric_enzyme sameAs Q3321436.
- Allosteric_enzyme sameAs Q3321436.
- Allosteric_enzyme sameAs 别构酶.
- Allosteric_enzyme wasDerivedFrom Allosteric_enzyme?oldid=629283908.
- Allosteric_enzyme isPrimaryTopicOf Allosteric_enzyme.