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- AlloMap_molecular_expression_testing abstract "AlloMap molecular expression testing, developed and commercialized by CareDx, formerly known as XDx, is a gene expression profiling test to identify heart transplant recipients with a low probability of one type of transplant rejection. The test is performed on a blood sample, providing a non-invasive test to help manage the care of patients post transplant. Prior to the availability of this test, the primary method for managing heart transplant rejection was the invasive technique of endomyocardial biopsy.Test results are reported as a single score indicating the probability of moderate/severe acute cellular rejection (ACR). The performance characteristics of the test make it best suited to help indicate that acute cellar rejection is not present. The score is based on the amount of RNA from each gene in a 20-gene panel comprising 11 rejection-related genes and 9 genes used for normalization and quality control. Many of the rejection-related genes are associated with biological pathways involved in the immune response and rejection processes.The test score is used, along with other standard clinical assessments, to evaluate the patient’s probability of acute cellular rejection and the need for additional evaluations. This test is not designed to be informative about other forms of heart rejections such as antibody-mediated rejection (AMR) or cardiac allograft vasculopathy (CAV). AlloMap has been commercially available since 2005 as a CLIA approved Laboratory Developed Test (LDT) and was cleared by the U.S. Food and Drug Administration (FDA) in 2008 as a Class II Medical Device. It is available only from the CareDx Reference Laboratory in Brisbane, CA.The use of the test is described in the recommendations for the non-invasive monitoring of acute heart transplant rejection in the first evidence-based clinical practice guidelines for the care of heart transplant recipients issued by the International Society of Heart and Lung Transplantation.CareDx, Inc., announced on June 3, 2014 that it has filed a registration statement on Form S-1 with the U.S. Securities and Exchange Commission relating to the proposed initial public offering of shares of its common stock.".
- AlloMap_molecular_expression_testing wikiPageExternalLink www.allomap.com.
- AlloMap_molecular_expression_testing wikiPageID "28667291".
- AlloMap_molecular_expression_testing wikiPageLength "8851".
- AlloMap_molecular_expression_testing wikiPageOutDegree "18".
- AlloMap_molecular_expression_testing wikiPageRevisionID "611714297".
- AlloMap_molecular_expression_testing wikiPageWikiLink Acute_rejection.
- AlloMap_molecular_expression_testing wikiPageWikiLink Allograft.
- AlloMap_molecular_expression_testing wikiPageWikiLink Allotransplantation.
- AlloMap_molecular_expression_testing wikiPageWikiLink Blood.
- AlloMap_molecular_expression_testing wikiPageWikiLink Cardiac.
- AlloMap_molecular_expression_testing wikiPageWikiLink Category:Blood_tests.
- AlloMap_molecular_expression_testing wikiPageWikiLink Category:DNA.
- AlloMap_molecular_expression_testing wikiPageWikiLink Category:Genomics.
- AlloMap_molecular_expression_testing wikiPageWikiLink DNA_microarray.
- AlloMap_molecular_expression_testing wikiPageWikiLink DNA_microarrays.
- AlloMap_molecular_expression_testing wikiPageWikiLink Food_and_Drug_Administration.
- AlloMap_molecular_expression_testing wikiPageWikiLink Heart.
- AlloMap_molecular_expression_testing wikiPageWikiLink Heart_transplantation.
- AlloMap_molecular_expression_testing wikiPageWikiLink Immune.
- AlloMap_molecular_expression_testing wikiPageWikiLink Immunity_(medical).
- AlloMap_molecular_expression_testing wikiPageWikiLink Negative_predictive_value.
- AlloMap_molecular_expression_testing wikiPageWikiLink Organ_transplant.
- AlloMap_molecular_expression_testing wikiPageWikiLink Organ_transplantation.
- AlloMap_molecular_expression_testing wikiPageWikiLink Positive_and_negative_predictive_values.
- AlloMap_molecular_expression_testing wikiPageWikiLink Positive_predictive_value.
- AlloMap_molecular_expression_testing wikiPageWikiLink RNA.
- AlloMap_molecular_expression_testing wikiPageWikiLink Real-time_polymerase_chain_reaction.
- AlloMap_molecular_expression_testing wikiPageWikiLink Transplant_rejection.
- AlloMap_molecular_expression_testing wikiPageWikiLinkText "AlloMap molecular expression testing".
- AlloMap_molecular_expression_testing hasPhotoCollection AlloMap_molecular_expression_testing.
- AlloMap_molecular_expression_testing wikiPageUsesTemplate Template:Reflist.
- AlloMap_molecular_expression_testing subject Category:Blood_tests.
- AlloMap_molecular_expression_testing subject Category:DNA.
- AlloMap_molecular_expression_testing subject Category:Genomics.
- AlloMap_molecular_expression_testing hypernym Expression.
- AlloMap_molecular_expression_testing type Article.
- AlloMap_molecular_expression_testing type Organisation.
- AlloMap_molecular_expression_testing type Article.
- AlloMap_molecular_expression_testing type Genomic.
- AlloMap_molecular_expression_testing type Omic.
- AlloMap_molecular_expression_testing comment "AlloMap molecular expression testing, developed and commercialized by CareDx, formerly known as XDx, is a gene expression profiling test to identify heart transplant recipients with a low probability of one type of transplant rejection. The test is performed on a blood sample, providing a non-invasive test to help manage the care of patients post transplant.".
- AlloMap_molecular_expression_testing label "AlloMap molecular expression testing".
- AlloMap_molecular_expression_testing sameAs m.0cz8h1k.
- AlloMap_molecular_expression_testing sameAs Q4732967.
- AlloMap_molecular_expression_testing sameAs Q4732967.
- AlloMap_molecular_expression_testing wasDerivedFrom AlloMap_molecular_expression_testing?oldid=611714297.
- AlloMap_molecular_expression_testing homepage www.allomap.com.
- AlloMap_molecular_expression_testing isPrimaryTopicOf AlloMap_molecular_expression_testing.