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- Allergic_inflammation abstract "Allergic inflammation is an important pathophysiological feature of several disabilities or medical conditions including allergic asthma, atopic dermatitis, allergic rhinitis and several ocular allergic diseases. Allergic reactions may generally be divided into two components; the early phase reaction, and the late phase reaction. While the contribution to the development of symptoms from each of the phases varies greatly between diseases, both are usually present and provide us a framework for understanding allergic disease.The early phase of the allergic reaction typically occurs within minutes, or even seconds, following allergen exposure and is also commonly referred to as the immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema.The late phase of a Type 1 reaction (which develops 8–12 hours and is mediated by mast cells) should not be confused with delayed hypersensitivity Type IV allergic reaction (which takes 48–72 hours to develop and is mediated by T cells). The products of the early phase reaction include chemokines and molecules that act on endothelial cells and cause them to express Intercellular adhesion molecule (such as vascular cell adhesion molecule and selectins), which together result in the recruitment and activation of leukocytes from the blood into the site of the allergic reaction. Typically, the infiltrating cells observed in allergic reactions contain a high proportion of lymphocytes, and especially, of eosinophils. The recruited eosinophils will degranulate releasing a number of cytotoxic molecules (including Major Basic Protein and eosinophil peroxidase) as well as produce a number of cytokines such as IL-5. The recruited T-cells are typically of the Th2 variety and the cytokines they produce lead to further recruitment of mast cells and eosinophils, and in plasma cell isotype switching to IgE which will bind to the mast cell FcεRI receptors and prime the individual for further allergic responses.".
- Allergic_inflammation thumbnail Tissues_Affected_In_Allergic_Inflammation.jpg?width=300.
- Allergic_inflammation wikiPageID "6862956".
- Allergic_inflammation wikiPageLength "5571".
- Allergic_inflammation wikiPageOutDegree "40".
- Allergic_inflammation wikiPageRevisionID "514330060".
- Allergic_inflammation wikiPageWikiLink Allergen.
- Allergic_inflammation wikiPageWikiLink Allergy.
- Allergic_inflammation wikiPageWikiLink Asthma.
- Allergic_inflammation wikiPageWikiLink Atopic_dermatitis.
- Allergic_inflammation wikiPageWikiLink Category:Allergology.
- Allergic_inflammation wikiPageWikiLink Category:Skin_physiology.
- Allergic_inflammation wikiPageWikiLink Cell_adhesion_molecule.
- Allergic_inflammation wikiPageWikiLink Chemokine.
- Allergic_inflammation wikiPageWikiLink Chemokines.
- Allergic_inflammation wikiPageWikiLink Cytokine.
- Allergic_inflammation wikiPageWikiLink Cytokines.
- Allergic_inflammation wikiPageWikiLink Cytotoxic.
- Allergic_inflammation wikiPageWikiLink Cytotoxicity.
- Allergic_inflammation wikiPageWikiLink Degranulation.
- Allergic_inflammation wikiPageWikiLink Disabilities.
- Allergic_inflammation wikiPageWikiLink Disability.
- Allergic_inflammation wikiPageWikiLink Disease.
- Allergic_inflammation wikiPageWikiLink Edema.
- Allergic_inflammation wikiPageWikiLink Endothelial.
- Allergic_inflammation wikiPageWikiLink Endothelium.
- Allergic_inflammation wikiPageWikiLink Eosinophil_granulocyte.
- Allergic_inflammation wikiPageWikiLink Eosinophil_peroxidase.
- Allergic_inflammation wikiPageWikiLink Eosinophils.
- Allergic_inflammation wikiPageWikiLink FCER1.
- Allergic_inflammation wikiPageWikiLink FcεRI.
- Allergic_inflammation wikiPageWikiLink Goblet_cell.
- Allergic_inflammation wikiPageWikiLink Goblet_cells.
- Allergic_inflammation wikiPageWikiLink Histamine.
- Allergic_inflammation wikiPageWikiLink Human_eye.
- Allergic_inflammation wikiPageWikiLink IgE.
- Allergic_inflammation wikiPageWikiLink Immunoglobulin_E.
- Allergic_inflammation wikiPageWikiLink Inflammation.
- Allergic_inflammation wikiPageWikiLink Intercellular_adhesion_molecule.
- Allergic_inflammation wikiPageWikiLink Interleukin_5.
- Allergic_inflammation wikiPageWikiLink Leukocytes.
- Allergic_inflammation wikiPageWikiLink Leukotriene.
- Allergic_inflammation wikiPageWikiLink Leukotrienes.
- Allergic_inflammation wikiPageWikiLink Lymphocyte.
- Allergic_inflammation wikiPageWikiLink Lymphocytes.
- Allergic_inflammation wikiPageWikiLink Major_Basic_Protein.
- Allergic_inflammation wikiPageWikiLink Major_basic_protein.
- Allergic_inflammation wikiPageWikiLink Mast_cell.
- Allergic_inflammation wikiPageWikiLink Medical_conditions.
- Allergic_inflammation wikiPageWikiLink Nerve_cells.
- Allergic_inflammation wikiPageWikiLink Neuron.
- Allergic_inflammation wikiPageWikiLink Plasma_cell.
- Allergic_inflammation wikiPageWikiLink Prostaglandin.
- Allergic_inflammation wikiPageWikiLink Prostaglandins.
- Allergic_inflammation wikiPageWikiLink Rhinitis.
- Allergic_inflammation wikiPageWikiLink Selectin.
- Allergic_inflammation wikiPageWikiLink Selectins.
- Allergic_inflammation wikiPageWikiLink Smooth_muscle.
- Allergic_inflammation wikiPageWikiLink Smooth_muscle_tissue.
- Allergic_inflammation wikiPageWikiLink T-cells.
- Allergic_inflammation wikiPageWikiLink T_cell.
- Allergic_inflammation wikiPageWikiLink T_helper_cell.
- Allergic_inflammation wikiPageWikiLink Th2.
- Allergic_inflammation wikiPageWikiLink Vasodilation.
- Allergic_inflammation wikiPageWikiLink Vasodilator.
- Allergic_inflammation wikiPageWikiLink White_blood_cell.
- Allergic_inflammation wikiPageWikiLink File:Tissues_Affected_In_Allergic_Inflammation.jpg.
- Allergic_inflammation wikiPageWikiLinkText "Allergic inflammation".
- Allergic_inflammation wikiPageWikiLinkText "allergic inflammation".
- Allergic_inflammation wikiPageWikiLinkText "human allergic disease".
- Allergic_inflammation wikiPageWikiLinkText "immune".
- Allergic_inflammation wikiPageWikiLinkText "inflammation".
- Allergic_inflammation hasPhotoCollection Allergic_inflammation.
- Allergic_inflammation subject Category:Allergology.
- Allergic_inflammation subject Category:Skin_physiology.
- Allergic_inflammation hypernym Feature.
- Allergic_inflammation type Work.
- Allergic_inflammation type Specialty.
- Allergic_inflammation comment "Allergic inflammation is an important pathophysiological feature of several disabilities or medical conditions including allergic asthma, atopic dermatitis, allergic rhinitis and several ocular allergic diseases. Allergic reactions may generally be divided into two components; the early phase reaction, and the late phase reaction.".
- Allergic_inflammation label "Allergic inflammation".
- Allergic_inflammation sameAs m.0gt3vd.
- Allergic_inflammation sameAs Q4732119.
- Allergic_inflammation sameAs Q4732119.
- Allergic_inflammation wasDerivedFrom Allergic_inflammation?oldid=514330060.
- Allergic_inflammation depiction Tissues_Affected_In_Allergic_Inflammation.jpg.
- Allergic_inflammation isPrimaryTopicOf Allergic_inflammation.