Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Akt/PKB_signaling_pathway> ?p ?o }
- PKB_signaling_pathway abstract "The Akt Pathway, or PI3K-Akt Pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are phosphatidylinositol 3-kinase (PI3K) and Akt, or Protein Kinase B.Initial stimulation by a growth factor causes activation of a cell surface receptor and phosphorylation of PI3K. Activated PI3K then phosphorylates lipids on the plasma membrane, forming second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP3). Akt, a serine/threonine kinase, is recruited to the membrane by interaction with these phosphoinositide docking sites, so that it can be fully activated.Activated Akt mediates downstream responses, including cell survival, growth, proliferation, cell migration and angiogenesis, by phosphorylating a range of intracellular proteins. The pathway is present in all cells of higher eukaryotes and is highly conserved.The pathway is highly regulated by multiple mechanisms, often involving cross-talk with other signalling pathways. Problems with PI3K-Akt pathway regulation can lead to increase in signalling activity. This has been linked to a range of diseases such as cancer and type II diabetes. A major antagonist of PI3K activity is PTEN, a tumour suppressor which is often mutated or lost in cancer cells. Akt phosphorylates as many as 100 different substrates, leading to a wide range of effects on the cell.".
- PKB_signaling_pathway thumbnail P13K-Akt_Pathway_Activated_by_RTK.png?width=300.
- PKB_signaling_pathway wikiPageExternalLink content.jsp?id=science-pathways-akt.
- PKB_signaling_pathway wikiPageExternalLink www_bget?hsa04151.
- PKB_signaling_pathway wikiPageID "19220477".
- PKB_signaling_pathway wikiPageLength "33749".
- PKB_signaling_pathway wikiPageOutDegree "173".
- PKB_signaling_pathway wikiPageRevisionID "669377279".
- PKB_signaling_pathway wikiPageWikiLink 14-3-3_protein.
- PKB_signaling_pathway wikiPageWikiLink ASK1.
- PKB_signaling_pathway wikiPageWikiLink Actin.
- PKB_signaling_pathway wikiPageWikiLink Adenomatous_polyposis_coli.
- PKB_signaling_pathway wikiPageWikiLink Amino_acid.
- PKB_signaling_pathway wikiPageWikiLink Angiogenesis.
- PKB_signaling_pathway wikiPageWikiLink Apoptosis.
- PKB_signaling_pathway wikiPageWikiLink Bcl-2.
- PKB_signaling_pathway wikiPageWikiLink Bcl-2-associated_death_promoter.
- PKB_signaling_pathway wikiPageWikiLink Bcl-xL.
- PKB_signaling_pathway wikiPageWikiLink Beta-catenin.
- PKB_signaling_pathway wikiPageWikiLink Breast_cancer.
- PKB_signaling_pathway wikiPageWikiLink CAMKK2.
- PKB_signaling_pathway wikiPageWikiLink CCDC88A.
- PKB_signaling_pathway wikiPageWikiLink CDKN1B.
- PKB_signaling_pathway wikiPageWikiLink CREB.
- PKB_signaling_pathway wikiPageWikiLink CREB-binding_protein.
- PKB_signaling_pathway wikiPageWikiLink Calcium_in_biology.
- PKB_signaling_pathway wikiPageWikiLink Cancer.
- PKB_signaling_pathway wikiPageWikiLink Caspase.
- PKB_signaling_pathway wikiPageWikiLink Caspase-9.
- PKB_signaling_pathway wikiPageWikiLink Category:Cell_signaling.
- PKB_signaling_pathway wikiPageWikiLink Caveolin_1.
- PKB_signaling_pathway wikiPageWikiLink Cell_cycle.
- PKB_signaling_pathway wikiPageWikiLink Cell_growth.
- PKB_signaling_pathway wikiPageWikiLink Cell_migration.
- PKB_signaling_pathway wikiPageWikiLink Cell_nucleus.
- PKB_signaling_pathway wikiPageWikiLink Cell_proliferation.
- PKB_signaling_pathway wikiPageWikiLink Conformational_change.
- PKB_signaling_pathway wikiPageWikiLink Consensus_sequence.
- PKB_signaling_pathway wikiPageWikiLink Cyclin-dependent_kinase.
- PKB_signaling_pathway wikiPageWikiLink Cyclin_D1.
- PKB_signaling_pathway wikiPageWikiLink Cytoskeleton.
- PKB_signaling_pathway wikiPageWikiLink Cytosol.
- PKB_signaling_pathway wikiPageWikiLink DNA-PKcs.
- PKB_signaling_pathway wikiPageWikiLink Diabetes_mellitus_type_2.
- PKB_signaling_pathway wikiPageWikiLink EGF.
- PKB_signaling_pathway wikiPageWikiLink EIF4E.
- PKB_signaling_pathway wikiPageWikiLink EIF4EBP1.
- PKB_signaling_pathway wikiPageWikiLink Endothelial_NOS.
- PKB_signaling_pathway wikiPageWikiLink Endothelium.
- PKB_signaling_pathway wikiPageWikiLink Epigenetics.
- PKB_signaling_pathway wikiPageWikiLink Epithelial-mesenchymal_transition.
- PKB_signaling_pathway wikiPageWikiLink Epithelial–mesenchymal_transition.
- PKB_signaling_pathway wikiPageWikiLink Eukaryote.
- PKB_signaling_pathway wikiPageWikiLink Eukaryotes.
- PKB_signaling_pathway wikiPageWikiLink Extracellular_matrix.
- PKB_signaling_pathway wikiPageWikiLink FLNA.
- PKB_signaling_pathway wikiPageWikiLink FOXO.
- PKB_signaling_pathway wikiPageWikiLink FOXO1.
- PKB_signaling_pathway wikiPageWikiLink FOXO3.
- PKB_signaling_pathway wikiPageWikiLink FOXO4.
- PKB_signaling_pathway wikiPageWikiLink FOX_proteins.
- PKB_signaling_pathway wikiPageWikiLink FYVE_domain.
- PKB_signaling_pathway wikiPageWikiLink File:Akt_Phosphorylation_Substrates_Affecting_Apoptosis.png.
- PKB_signaling_pathway wikiPageWikiLink File:Akt_Substrates_Involved_in_Cell_Cycle_Regulation.png.
- PKB_signaling_pathway wikiPageWikiLink File:Molecular_Structure_of_Phosphoinositol_3,4,5-Trisphosphate.png.
- PKB_signaling_pathway wikiPageWikiLink File:P13K-Akt_Pathway_Activated_by_RTK.png.
- PKB_signaling_pathway wikiPageWikiLink File:PI3K-Akt_Pathways_with_a_role_in_Cancer.png.
- PKB_signaling_pathway wikiPageWikiLink File:Regulation_of_P13K-Akt_Pathway_in_Feedback_Loops.png.
- PKB_signaling_pathway wikiPageWikiLink GAB1.
- PKB_signaling_pathway wikiPageWikiLink GLUT1.
- PKB_signaling_pathway wikiPageWikiLink GLUT4.
- PKB_signaling_pathway wikiPageWikiLink GRB2.
- PKB_signaling_pathway wikiPageWikiLink GSK-3.
- PKB_signaling_pathway wikiPageWikiLink GSK3B.
- PKB_signaling_pathway wikiPageWikiLink GTPase-activating_protein.
- PKB_signaling_pathway wikiPageWikiLink G_protein-coupled_receptor.
- PKB_signaling_pathway wikiPageWikiLink G_protein–coupled_receptor.
- PKB_signaling_pathway wikiPageWikiLink Gene_duplication.
- PKB_signaling_pathway wikiPageWikiLink Girdin.
- PKB_signaling_pathway wikiPageWikiLink Glioblastoma.
- PKB_signaling_pathway wikiPageWikiLink Glioblastoma_multiforme.
- PKB_signaling_pathway wikiPageWikiLink Glycogen.
- PKB_signaling_pathway wikiPageWikiLink Glycogen_synthase_kinase_3.
- PKB_signaling_pathway wikiPageWikiLink Glycolysis.
- PKB_signaling_pathway wikiPageWikiLink Grb2.
- PKB_signaling_pathway wikiPageWikiLink Growth_factor.
- PKB_signaling_pathway wikiPageWikiLink Heat_shock.
- PKB_signaling_pathway wikiPageWikiLink Hexokinase.
- PKB_signaling_pathway wikiPageWikiLink Hormone.
- PKB_signaling_pathway wikiPageWikiLink Hormones.
- PKB_signaling_pathway wikiPageWikiLink Hypoxia-inducible_factors.
- PKB_signaling_pathway wikiPageWikiLink INPP5D.
- PKB_signaling_pathway wikiPageWikiLink IRS1.
- PKB_signaling_pathway wikiPageWikiLink Insulin.
- PKB_signaling_pathway wikiPageWikiLink Insulin_receptor_substrate.
- PKB_signaling_pathway wikiPageWikiLink Integrin.
- PKB_signaling_pathway wikiPageWikiLink Integrin-linked_kinase.
- PKB_signaling_pathway wikiPageWikiLink Intermediate_filament.
- PKB_signaling_pathway wikiPageWikiLink IκB_kinase.
- PKB_signaling_pathway wikiPageWikiLink MAP3K13.