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- Afamelanotide abstract "Note: this article describes afamelanotide which is also known by the name melanotan I. afamelanotide should not be confused with melanotan II.Afamelanotide (/ˌæfəmɛˈlænɵtaɪd/ (INN) (brand name Scenesse), also known as melanotan I (or melanotan-1), originally developed at the University of Arizona and now by Clinuvel Pharmaceuticals, is a synthetic peptide and analogue of the naturally occurring melanocortin peptide hormone α-melanocyte stimulating hormone (α-MSH) that has been shown to induce skin pigmentation through melanogenesis and thereby subsequently reduce sun (UV) damage to UV light-exposed skin in preliminary research and clinical trials. Its amino acid sequence is Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2, and it is additionally known as [Nle4,D-Phe7]-α-MSH, which is sometimes abbreviated as NDP-MSH or NDP-α-MSH (especially in the scientific literature).Afamelanotide is the International Nonproprietary Name for the molecule [Nle4,D-Phe7]α-MSH initially researched and developed as melanotan-1 /mɛˈlænɵtæn/ and later, CUV1647 (by Clinuvel). A marketing trade name for one brand of afamelanotide was approved in 2010 by the European Medicines Agency (EMA) Name Review Group (NRG) and the agency's Committee for Medicinal Products for Human Use (CHMP) as Scenesse (pronounced "sen-esse"). On May 5, 2010 the Italian Medicines Agency (AIFA, or Agenzia Italiana del Farmaco) became the first governmental health organization ever (even before the drug received approval in Europe) to authorize afamelanotide as a medicine for therapeutic treatment of Italian citizens to reduce painful photosensitivity stemming from the orphan disease erythropoietic protoporphyria (EPP). This approval allowed the drug to be immediately available for prescription in Italy and reimbursable under the country's national health system. Authorities in Switzerland have also allowed prescription of the drug for EPP with reimbursement approved by two unnamed insurers. Afamelanotide is currently being trialed in the form of a "grain of rice"-sized bioabsorbable subcutaneous implant as a potential therapeutic photoprotection-inducing agent for a series of light-related skin indications as well as a potential dermal repigmentation agent for vitiligo. Afamelanotide, as of October 24, 2014, has been approved by the EMA in Europe for the treatment of EPP. Clinuvel now intends to seek approval of afamelanotide in the United States.Unlicensed and untested powders sold as "melanotan" are found on the Internet and are reported to be used by tens of thousands of members of the general public. Multiple regulatory bodies have warned consumers that the peptides may be unsafe and ineffective in usage, with one regulatory agency warning that consumers who purchase any product labeled "melanotan" risk buying a counterfeit drug. Clinuvel Pharmaceuticals, the developer of afamelanotide, and medical researchers have warned consumers that counterfeit products sold using the names "melanotan I and II", could "pose a hazard to public health". Clinuvel has stated publicly that products sold online as "melanotan" are not afamelanotide.".
- Afamelanotide atcPrefix "D02".
- Afamelanotide atcSuffix "BB02".
- Afamelanotide casNumber "75921-69-6".
- Afamelanotide fdaUniiCode "QW68W3J66U".
- Afamelanotide iupacName "N-acetyl-(L)-seryl-(L)-tyrosyl-(L)-seryl-(L)-norleucyl-(L)-α-glutamyl-(L)-histidyl-(D)-phenylalanyl-(L)-arginyl-(L)-tryptophylglycyl-(L)-lysyl-(L)-prolyl-(L)-valinamide".
- Afamelanotide pubchem "16154396".
- Afamelanotide thumbnail Melanotan.png?width=300.
- Afamelanotide wikiPageExternalLink summary.cgi?sid=734258.
- Afamelanotide wikiPageExternalLink www.clinuvel.com.
- Afamelanotide wikiPageID "17981721".
- Afamelanotide wikiPageLength "46335".
- Afamelanotide wikiPageOutDegree "192".
- Afamelanotide wikiPageRevisionID "681482076".
- Afamelanotide wikiPageWikiLink ACTH_receptor.
- Afamelanotide wikiPageWikiLink Academia.
- Afamelanotide wikiPageWikiLink Actinic_keratosis.
- Afamelanotide wikiPageWikiLink Adenosine_triphosphate.
- Afamelanotide wikiPageWikiLink Adenylate_cyclase.
- Afamelanotide wikiPageWikiLink Agonist.
- Afamelanotide wikiPageWikiLink Allele.
- Afamelanotide wikiPageWikiLink Alpha-Melanocyte-stimulating_hormone.
- Afamelanotide wikiPageWikiLink Animal_model.
- Afamelanotide wikiPageWikiLink Animal_research.
- Afamelanotide wikiPageWikiLink Animal_testing.
- Afamelanotide wikiPageWikiLink Australia.
- Afamelanotide wikiPageWikiLink BMJ.
- Afamelanotide wikiPageWikiLink BMS-470,539.
- Afamelanotide wikiPageWikiLink Binding_selectivity.
- Afamelanotide wikiPageWikiLink Biological_pigment.
- Afamelanotide wikiPageWikiLink Biological_system.
- Afamelanotide wikiPageWikiLink Biomedical_research.
- Afamelanotide wikiPageWikiLink Biomimetics.
- Afamelanotide wikiPageWikiLink Biomimicry.
- Afamelanotide wikiPageWikiLink Bremelanotide.
- Afamelanotide wikiPageWikiLink CAMP_response_element.
- Afamelanotide wikiPageWikiLink CAMP_response_element-binding.
- Afamelanotide wikiPageWikiLink CREB.
- Afamelanotide wikiPageWikiLink Carcinogen.
- Afamelanotide wikiPageWikiLink Category:Melanocortin_receptor_agonists.
- Afamelanotide wikiPageWikiLink Category:Peptides.
- Afamelanotide wikiPageWikiLink Cell_(biology).
- Afamelanotide wikiPageWikiLink Clinical_trial.
- Afamelanotide wikiPageWikiLink Clinuvel_Pharmaceuticals.
- Afamelanotide wikiPageWikiLink Committee_for_Medicinal_Products_for_Human_Use.
- Afamelanotide wikiPageWikiLink Congenital_erythropoietic_porphyria.
- Afamelanotide wikiPageWikiLink Counterfeit_drug.
- Afamelanotide wikiPageWikiLink Counterfeit_medications.
- Afamelanotide wikiPageWikiLink Cyclic_adenosine_monophosphate.
- Afamelanotide wikiPageWikiLink Danish_Medicines_Agency.
- Afamelanotide wikiPageWikiLink Domestic_policy.
- Afamelanotide wikiPageWikiLink Dopachrome_tautomerase.
- Afamelanotide wikiPageWikiLink Editorial.
- Afamelanotide wikiPageWikiLink Efficacy.
- Afamelanotide wikiPageWikiLink Endogeny.
- Afamelanotide wikiPageWikiLink Endogeny_(biology).
- Afamelanotide wikiPageWikiLink Enzyme.
- Afamelanotide wikiPageWikiLink Epidermis.
- Afamelanotide wikiPageWikiLink Epidermis_(skin).
- Afamelanotide wikiPageWikiLink Erythropoietic_protoporphyria.
- Afamelanotide wikiPageWikiLink Eumelanin.
- Afamelanotide wikiPageWikiLink Europe.
- Afamelanotide wikiPageWikiLink European_Medicines_Agency.
- Afamelanotide wikiPageWikiLink Export.
- Afamelanotide wikiPageWikiLink FDA_Warning_Letter.
- Afamelanotide wikiPageWikiLink Federal_Food,_Drug,_and_Cosmetic_Act.
- Afamelanotide wikiPageWikiLink Fitzpatrick_scale.
- Afamelanotide wikiPageWikiLink Food_and_Drug_Administration.
- Afamelanotide wikiPageWikiLink Food_and_Drug_Administration_(United_States).
- Afamelanotide wikiPageWikiLink Gene.
- Afamelanotide wikiPageWikiLink Gunther_disease.
- Afamelanotide wikiPageWikiLink Half-life.
- Afamelanotide wikiPageWikiLink Half_life.
- Afamelanotide wikiPageWikiLink Healthcare_in_Italy.
- Afamelanotide wikiPageWikiLink Human_skin.
- Afamelanotide wikiPageWikiLink Hypothesis.
- Afamelanotide wikiPageWikiLink Import.
- Afamelanotide wikiPageWikiLink In_vitro.
- Afamelanotide wikiPageWikiLink In_vivo.
- Afamelanotide wikiPageWikiLink Indication_(medicine).
- Afamelanotide wikiPageWikiLink Injection_(medicine).
- Afamelanotide wikiPageWikiLink Insufflation_(medicine).
- Afamelanotide wikiPageWikiLink International_Nonproprietary_Name.
- Afamelanotide wikiPageWikiLink Intramuscular_injection.
- Afamelanotide wikiPageWikiLink Intranasal.
- Afamelanotide wikiPageWikiLink Intravenous_injection.
- Afamelanotide wikiPageWikiLink Intravenous_therapy.
- Afamelanotide wikiPageWikiLink Italian_Medicines_Agency.
- Afamelanotide wikiPageWikiLink Italians.
- Afamelanotide wikiPageWikiLink Journalist.
- Afamelanotide wikiPageWikiLink Light.
- Afamelanotide wikiPageWikiLink Liverpool_John_Moores_University.
- Afamelanotide wikiPageWikiLink Malignancy.
- Afamelanotide wikiPageWikiLink Malignant.
- Afamelanotide wikiPageWikiLink Mammal.
- Afamelanotide wikiPageWikiLink Mammalian.
- Afamelanotide wikiPageWikiLink Mechanism_of_action.
- Afamelanotide wikiPageWikiLink Medical_research.
- Afamelanotide wikiPageWikiLink Medicines_and_Healthcare_Products_Regulatory_Agency.
- Afamelanotide wikiPageWikiLink Medicines_and_Healthcare_products_Regulatory_Agency.