Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Addiction> ?p ?o }
- Addiction abstract "Addiction is a state characterized by compulsive engagement in rewarding stimuli, despite adverse consequences. It can be thought of as a disease or biological process leading to such behaviors. The two properties that characterize all addictive stimuli are that they are reinforcing (i.e., they increase the likelihood that a person will seek repeated exposure to them) and intrinsically rewarding (i.e., something perceived as being positive or desirable).Addiction is a disorder of the brain's reward system which arises through transcriptional and epigenetic mechanisms and occurs over time from chronically high levels of exposure to an addictive stimulus (e.g., morphine, cocaine, sexual intercourse, gambling, etc.). ΔFosB, a gene transcription factor, is a critical component and common factor in the development of virtually all forms of behavioral and drug addictions; two decades of research into ΔFosB's role in addiction have demonstrated that addiction arises, and addictive behavior intensifies or attenuates, along with the genetic overexpression of ΔFosB in the D1-type medium spiny neurons of the nucleus accumbens; due to the causal relationship between ΔFosB expression and addictions, it is used preclinically as an addiction biomarker. ΔFosB expression in these neurons directly and positively regulates drug self-administration and reward sensitization through positive reinforcement, while decreasing sensitivity to aversion.Addiction exacts an astoundingly high toll on individuals and society as a whole through the direct adverse effects of drugs, associated healthcare costs, long-term complications (e.g., lung cancer with smoking tobacco, liver cirrhosis with drinking alcohol, or meth mouth from intravenous methamphetamine), the functional consequences of altered neural plasticity in the brain, and the consequent loss of productivity. Classic hallmarks of addiction include impaired control over substances or behavior, preoccupation with substance or behavior, and continued use despite consequences. Habits and patterns associated with addiction are typically characterized by immediate gratification (short-term reward), coupled with delayed deleterious effects (long-term costs).Examples of drug and behavioral addictions include: alcoholism, amphetamine addiction, cocaine addiction, nicotine addiction, opiate addiction, exercise addiction, food addiction, gambling addiction, and sexual addiction. The term addiction is misused frequently to refer to other compulsive behaviors or disorders, particularly dependence, in news media.".
- Addiction wikiPageExternalLink show_pathway?hsa05030+2354.
- Addiction wikiPageExternalLink show_pathway?hsa05031+2354.
- Addiction wikiPageExternalLink show_pathway?hsa05034+2354.
- Addiction wikiPageExternalLink tbl3.
- Addiction wikiPageID "27158894".
- Addiction wikiPageLength "86010".
- Addiction wikiPageOutDegree "219".
- Addiction wikiPageRevisionID "682495415".
- Addiction wikiPageWikiLink 18-Methoxycoronaridine.
- Addiction wikiPageWikiLink 18-methoxycoronaridine.
- Addiction wikiPageWikiLink AMPA.
- Addiction wikiPageWikiLink AMPAR.
- Addiction wikiPageWikiLink AMPA_receptor.
- Addiction wikiPageWikiLink Acamprosate.
- Addiction wikiPageWikiLink Addiction.
- Addiction wikiPageWikiLink Affect_(psychology).
- Addiction wikiPageWikiLink Affect_dysregulation.
- Addiction wikiPageWikiLink Affective_science.
- Addiction wikiPageWikiLink Alcoholism.
- Addiction wikiPageWikiLink Amphetamine.
- Addiction wikiPageWikiLink Amphetamine_addiction.
- Addiction wikiPageWikiLink Anhedonia.
- Addiction wikiPageWikiLink Anterior_cingulate.
- Addiction wikiPageWikiLink Anterior_cingulate_cortex.
- Addiction wikiPageWikiLink Anxiety.
- Addiction wikiPageWikiLink Baclofen.
- Addiction wikiPageWikiLink Basolateral_amygdala.
- Addiction wikiPageWikiLink Behavioral_addiction.
- Addiction wikiPageWikiLink Biomarker_(medicine).
- Addiction wikiPageWikiLink Brain_biopsy.
- Addiction wikiPageWikiLink Buprenorphine.
- Addiction wikiPageWikiLink Bupropion.
- Addiction wikiPageWikiLink C-Fos.
- Addiction wikiPageWikiLink CAMP_response_element_binding_protein.
- Addiction wikiPageWikiLink CREB.
- Addiction wikiPageWikiLink Cannabinoid.
- Addiction wikiPageWikiLink Category:Addiction.
- Addiction wikiPageWikiLink Category:Behavioral_addiction.
- Addiction wikiPageWikiLink Category:Mental_health.
- Addiction wikiPageWikiLink Category:Psychiatric_diseases_and_disorders.
- Addiction wikiPageWikiLink Cdk5.
- Addiction wikiPageWikiLink Chemical_synapse.
- Addiction wikiPageWikiLink Cholinergic_neuron.
- Addiction wikiPageWikiLink Cirrhosis.
- Addiction wikiPageWikiLink Cocaine.
- Addiction wikiPageWikiLink Cocaine_addiction.
- Addiction wikiPageWikiLink Cocaine_dependence.
- Addiction wikiPageWikiLink Cochrane_Collaboration.
- Addiction wikiPageWikiLink Compulsive_behavior.
- Addiction wikiPageWikiLink Compulsive_buying_disorder.
- Addiction wikiPageWikiLink Craving_(withdrawal).
- Addiction wikiPageWikiLink Cyclic_adenosine_monophosphate.
- Addiction wikiPageWikiLink Cyclin-dependent_kinase_5.
- Addiction wikiPageWikiLink D1-like_receptor.
- Addiction wikiPageWikiLink D1-type.
- Addiction wikiPageWikiLink DATA_2000.
- Addiction wikiPageWikiLink DSM-5.
- Addiction wikiPageWikiLink Demographics.
- Addiction wikiPageWikiLink Demography.
- Addiction wikiPageWikiLink Diagnostic_and_Statistical_Manual_of_Mental_Disorders.
- Addiction wikiPageWikiLink Dihydrocodeine.
- Addiction wikiPageWikiLink Dihydroetorphine.
- Addiction wikiPageWikiLink Disulfiram.
- Addiction wikiPageWikiLink Dopamine.
- Addiction wikiPageWikiLink Dopamine_dysregulation_syndrome.
- Addiction wikiPageWikiLink Dopamine_receptor.
- Addiction wikiPageWikiLink Dopaminergic.
- Addiction wikiPageWikiLink Dopaminergic_pathways.
- Addiction wikiPageWikiLink Downregulation_and_upregulation.
- Addiction wikiPageWikiLink Drug_Addiction_Treatment_Act.
- Addiction wikiPageWikiLink Drug_withdrawal.
- Addiction wikiPageWikiLink Dynorphin.
- Addiction wikiPageWikiLink EHMT2.
- Addiction wikiPageWikiLink Emotional_dysregulation.
- Addiction wikiPageWikiLink Endophenotype.
- Addiction wikiPageWikiLink Epigenetic.
- Addiction wikiPageWikiLink Epigenetics.
- Addiction wikiPageWikiLink Exercise_addiction.
- Addiction wikiPageWikiLink Extinction_(psychology).
- Addiction wikiPageWikiLink FOSB.
- Addiction wikiPageWikiLink Food_addiction.
- Addiction wikiPageWikiLink Forebrain.
- Addiction wikiPageWikiLink G9a.
- Addiction wikiPageWikiLink GABA.
- Addiction wikiPageWikiLink GRIA1.
- Addiction wikiPageWikiLink Gabapentin.
- Addiction wikiPageWikiLink Gambling_addiction.
- Addiction wikiPageWikiLink Gamma-Aminobutyric_acid.
- Addiction wikiPageWikiLink Gene_expression.
- Addiction wikiPageWikiLink Gene_transcription.
- Addiction wikiPageWikiLink Genetic_engineering.
- Addiction wikiPageWikiLink Genome-wide_association_study.
- Addiction wikiPageWikiLink Glossary_of_gene_expression_terms.
- Addiction wikiPageWikiLink GluR1.
- Addiction wikiPageWikiLink GluR2.
- Addiction wikiPageWikiLink Glutamate.
- Addiction wikiPageWikiLink Glutamic_acid.
- Addiction wikiPageWikiLink Hallucination.
- Addiction wikiPageWikiLink Hallucinations.