Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Acyl_CoA_dehydrogenase> ?p ?o }
- Acyl_CoA_dehydrogenase abstract "Acyl-CoA dehydrogenases (ACADs) are a class of enzymes that function to catalyze the initial step in each cycle of fatty acid β-oxidation in the mitochondria of cells. Their action results in the introduction of a trans double-bond between C2 (α) and C3 (β) of the acyl-CoA thioester substrate. Flavin adenine dinucleotide (FAD) is a required co-factor in addition to the presence of an active site glutamate in order for the enzyme to function.The following reaction is the oxidation of the fatty acid by FAD to afford an α,β-unsaturated fatty acid thioester of Coenzyme A:ACADs can be categorized into three distinct groups based on their specificity for short-, medium-, or long-chain fatty acid acyl-CoA substrates. While different dehydrogenases target fatty acids of varying chain length, all types of ACADs are mechanistically similar. Differences in the enzyme occur based on the location of the active site along the amino acid sequence.ACADs are an important class of enzymes in mammalian cells because of their role in metabolizing fatty acids present in ingested food materials. This enzyme's action represents the first step in fatty acid metabolism (the process of breaking long chains of fatty acids into acetyl CoA molecules). Deficiencies in these enzymes are linked to genetic disorders involving fatty acid oxidation (i.e. metabolic disorders).ACAD enzymes have been identified in animals (of which there are 9 major eukaryotic classes), as well as plants, nematodes, fungi, and bacteria. Five of these nine classes are involved in fatty acid β-oxidation (SCAD, MCAD, LCAD, VLCAD, and VLCAD2), and the other four are involved in branched chain amino acid metabolism (i3VD, i2VD, GD, and iBD). Most acyl-CoA dehydrogenases are α4 homotetramers, and in two cases (for very long chain fatty acid substrates) they are α2 homodimers. An additional class of acyl-CoA dehydrogenase was discovered that catalyzes α,β-unsaturation reactions with steroid-CoA thioesters in certain types of bacteria. This class of ACAD was demonstrated to form α2β2 heterotetramers, rather than the usual α4 homotetramer, a protein architecture that evolved in order to accommodate a much larger steroid-CoA substrate.ACADs are classified as EC 1.3.99.3.".
- Acyl_CoA_dehydrogenase thumbnail Beta-Oxidation1.svg?width=300.
- Acyl_CoA_dehydrogenase wikiPageExternalLink pmidlookup?view=long&pmid=7275979.
- Acyl_CoA_dehydrogenase wikiPageID "5625926".
- Acyl_CoA_dehydrogenase wikiPageLength "16573".
- Acyl_CoA_dehydrogenase wikiPageOutDegree "130".
- Acyl_CoA_dehydrogenase wikiPageRevisionID "679075212".
- Acyl_CoA_dehydrogenase wikiPageWikiLink Acidosis.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Actinobacteria.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Acyl-CoA.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Acyl_CoA.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Amino_acid.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Amino_acids.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Angstrom.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Beta_oxidation.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Binding_site.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Binding_sites.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Blood.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Carbon.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Category:EC_1.3.99.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Cell_(biology).
- Acyl_CoA_dehydrogenase wikiPageWikiLink Child.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Children.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Coenzyme_A.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Deficiency_(medicine).
- Acyl_CoA_dehydrogenase wikiPageWikiLink Disease.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Diseases.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Dominance_(genetics).
- Acyl_CoA_dehydrogenase wikiPageWikiLink Double-bond.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Double_bond.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Electron.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Electrons.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Energy.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Enzyme.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Enzymes.
- Acyl_CoA_dehydrogenase wikiPageWikiLink FAD.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Fasting.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Fat.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Fatty_acid.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Fatty_acids.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Flavin_adenine_dinucleotide.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Gene_duplication.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Genetics.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Glutamate.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Glutamic_acid.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Human.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Humans.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Hydrogen.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Hydrogen_bond.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Hydrogen_bonds.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Hydrophobe.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Hydrophobic.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Hypoglycemia.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Infant.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Infants.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Lysine.
- Acyl_CoA_dehydrogenase wikiPageWikiLink MCADD.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Mammal.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Mammalian.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Medium-chain_acyl-coenzyme_A_dehydrogenase_deficiency.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Metabolism.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Mitochondria.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Mitochondrion.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Mutation.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Nitrogen.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Octanoyl-CoA.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Open_reading_frame.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Open_reading_frames.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Oxidation.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Oxygen.
- Acyl_CoA_dehydrogenase wikiPageWikiLink PH.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Parent.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Parents.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Protein.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Proteobacteria.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Proton.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Pyrimidine.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Recessive.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Redox.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Saturated_and_unsaturated_compounds.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Substrate_(biology).
- Acyl_CoA_dehydrogenase wikiPageWikiLink Sudden_Infant_Death.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Sudden_infant_death_syndrome.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Sugar.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Thioester.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Wikt:trans-.
- Acyl_CoA_dehydrogenase wikiPageWikiLink Β-oxidation.
- Acyl_CoA_dehydrogenase wikiPageWikiLink File:AcylCoAdehydrogenase.png.
- Acyl_CoA_dehydrogenase wikiPageWikiLink File:Acyl_CoA_dehydrogenase_active_site.jpg.
- Acyl_CoA_dehydrogenase wikiPageWikiLink File:Acyl_CoA_tetramer.jpg.
- Acyl_CoA_dehydrogenase wikiPageWikiLink File:Beta-Oxidation1.svg.
- Acyl_CoA_dehydrogenase wikiPageWikiLinkText "Acetyl-CoA-dehydrogenases".
- Acyl_CoA_dehydrogenase wikiPageWikiLinkText "Acyl CoA dehydrogenase".
- Acyl_CoA_dehydrogenase wikiPageWikiLinkText "acyl CoA dehydrogenase".
- Acyl_CoA_dehydrogenase wikiPageWikiLinkText "acyl-CoA dehydrogenases".
- Acyl_CoA_dehydrogenase hasPhotoCollection Acyl_CoA_dehydrogenase.
- Acyl_CoA_dehydrogenase wikiPageUsesTemplate Template:CH-CH_oxidoreductases.
- Acyl_CoA_dehydrogenase wikiPageUsesTemplate Template:Cite_journal.
- Acyl_CoA_dehydrogenase wikiPageUsesTemplate Template:EC_number.
- Acyl_CoA_dehydrogenase wikiPageUsesTemplate Template:Flavoproteins.