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- ATP_synthase_subunit_C abstract "ATPase, subunit C of F0/V0 complex is the main transmembrane subunit of V-type, A-type and F-type ATP synthases.ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. Some ATPases work in reverse,using the energy from the hydrolysis of ATP to create a proton gradient. There are different types of ATPases, which candiffer in function (ATP synthesis and/or hydrolysis), structure (F-, V- and A-ATPases contain rotary motors) and in the type of ions they transport. F-ATPases (F1F0-ATPases) in mitochondria, chloroplasts and bacterial plasma membranes are the prime producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). V-ATPase (V1V0-ATPases) are primarily found in eukaryotic vacuoles, catalysing ATP hydrolysis to transport solutes and lower pH in organelles. A-ATPases (A1A0-ATPases) are found in Archaea and function like F-ATPases. P-ATPases (E1E2-ATPases) are found in bacteria and in eukaryotic plasma membranes and organelles, and function to transport a variety of different ions across membranes. E-ATPases are cell-surface enzymes that hydrolyse a range of NTPs, including extracellular ATP.The F-ATPases (or F1F0-ATPases) and V-ATPases (or V1V0-ATPases) are each composed of two linked complexes: the F1 or V1 complex contains the catalytic core that synthesizes/hydrolyses ATP, and the F0 or V0 complex that forms the membrane-spanning pore. The F- and V-ATPases all contain rotary motors, one that drives proton translocation across the membrane and one that drives ATP synthesis/hydrolysis.Subunit C (also called subunit 9, or proteolipid in F-ATPases, or the 16 kDa proteolipid in V-ATPases) was found in the F0 or V0 complex of F- and V-ATPases, respectively. In F-ATPases, ten C subunits form an oligomeric ring that makes up the F0 rotor. The flux of protons through the ATPase channel drives the rotation of the C subunit ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the C subunit ring of F0. The sequential protonation and deprotonation of Asp61 of subunit C is coupled to the stepwise movement of the rotor.In V-ATPases, there are three proteolipid subunits (c, c′ and c′′) that form part of the proton-conducting pore, each containing a buried glutamic acid residue that is essential for proton transport, and together they form a hexameric ring spanning the membrane.In a recent study c-subunit has been indicated as a critical component of the mitochondrial permeability transition pore.".
- ATP_synthase_subunit_C symbol "ATP-synt_C".
- ATP_synthase_subunit_C thumbnail 2bl2.png?width=300.
- ATP_synthase_subunit_C wikiPageID "14662962".
- ATP_synthase_subunit_C wikiPageLength "6528".
- ATP_synthase_subunit_C wikiPageOutDegree "16".
- ATP_synthase_subunit_C wikiPageRevisionID "674428376".
- ATP_synthase_subunit_C wikiPageWikiLink ATP5G1.
- ATP_synthase_subunit_C wikiPageWikiLink ATP5G2.
- ATP_synthase_subunit_C wikiPageWikiLink ATP5G3.
- ATP_synthase_subunit_C wikiPageWikiLink ATP6V0B.
- ATP_synthase_subunit_C wikiPageWikiLink ATP6V0C.
- ATP_synthase_subunit_C wikiPageWikiLink ATP_synthase.
- ATP_synthase_subunit_C wikiPageWikiLink ATPase.
- ATP_synthase_subunit_C wikiPageWikiLink ATPase,_F0_complex,_subunit_C.
- ATP_synthase_subunit_C wikiPageWikiLink ATPase,_V0_complex,_proteolipid_subunit_C.
- ATP_synthase_subunit_C wikiPageWikiLink Category:Protein_domains.
- ATP_synthase_subunit_C wikiPageWikiLink Category:Protein_families.
- ATP_synthase_subunit_C wikiPageWikiLink Category:Transmembrane_proteins.
- ATP_synthase_subunit_C wikiPageWikiLink Diarylquinoline.
- ATP_synthase_subunit_C wikiPageWikiLink Enterococcus_hirae.
- ATP_synthase_subunit_C wikiPageWikiLink Lipid_bilayer.
- ATP_synthase_subunit_C wikiPageWikiLink V-ATPase.
- ATP_synthase_subunit_C wikiPageWikiLinkText "ATP synthase subunit C".
- ATP_synthase_subunit_C wikiPageWikiLinkText "C subunit".
- ATP_synthase_subunit_C wikiPageWikiLinkText "C".
- ATP_synthase_subunit_C wikiPageWikiLinkText "c-ring".
- ATP_synthase_subunit_C wikiPageWikiLinkText "c-subunits".
- ATP_synthase_subunit_C wikiPageWikiLinkText "subunit c".
- ATP_synthase_subunit_C caption "V-type sodium ATPase from Enterococcus hirae. Calculated hydrocarbon boundaries of the lipid bilayer are shown by red and blue dots".
- ATP_synthase_subunit_C hasPhotoCollection ATP_synthase_subunit_C.
- ATP_synthase_subunit_C interpro "IPR002379".
- ATP_synthase_subunit_C opmFamily "5".
- ATP_synthase_subunit_C opmProtein "2".
- ATP_synthase_subunit_C pfam "PF00137".
- ATP_synthase_subunit_C prosite "PDOC00526".
- ATP_synthase_subunit_C scop "1".
- ATP_synthase_subunit_C symbol "ATP-synt_C".
- ATP_synthase_subunit_C width "250".
- ATP_synthase_subunit_C wikiPageUsesTemplate Template:InterPro.
- ATP_synthase_subunit_C wikiPageUsesTemplate Template:InterPro_content.
- ATP_synthase_subunit_C wikiPageUsesTemplate Template:Pfam_box.
- ATP_synthase_subunit_C wikiPageUsesTemplate Template:Reflist.
- ATP_synthase_subunit_C subject Category:Protein_domains.
- ATP_synthase_subunit_C subject Category:Protein_families.
- ATP_synthase_subunit_C subject Category:Transmembrane_proteins.
- ATP_synthase_subunit_C hypernym Subunit.
- ATP_synthase_subunit_C type Biomolecule.
- ATP_synthase_subunit_C type Protein.
- ATP_synthase_subunit_C type Chemical.
- ATP_synthase_subunit_C type Domain.
- ATP_synthase_subunit_C type Thing.
- ATP_synthase_subunit_C type Q206229.
- ATP_synthase_subunit_C type Q8054.
- ATP_synthase_subunit_C comment "ATPase, subunit C of F0/V0 complex is the main transmembrane subunit of V-type, A-type and F-type ATP synthases.ATPases (or ATP synthases) are membrane-bound enzyme complexes/ion transporters that combine ATP synthesis and/or hydrolysis with the transport of protons across a membrane. ATPases can harness the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP.".
- ATP_synthase_subunit_C label "ATP synthase subunit C".
- ATP_synthase_subunit_C sameAs m.03gs946.
- ATP_synthase_subunit_C sameAs Q4654888.
- ATP_synthase_subunit_C sameAs Q4654888.
- ATP_synthase_subunit_C wasDerivedFrom ATP_synthase_subunit_C?oldid=674428376.
- ATP_synthase_subunit_C depiction 2bl2.png.
- ATP_synthase_subunit_C isPrimaryTopicOf ATP_synthase_subunit_C.