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- ATP_cone abstract "In molecular biology, the ATP-cone is an evolutionarily mobile, ATP-binding regulatory domain which is found in a variety of proteins including ribonucleotide reductases, phosphoglycerate kinases and transcriptional regulators.In ribonucleotide reductase protein R1 from Escherichia coli this domain is located at the N terminus, and is composed mostly of helices. It forms part of the allosteric effector region and contains the general allosteric activity site in a cleft located at the tip of the N-terminal region. This site binds either ATP (activating) or dATP (inhibitory), with the base bound in a hydrophobic pocket and the phosphates bound to basic residues. Substrate binding to this site is thought to affect enzyme activity by altering the relative positions of the two subunits of ribonucleotide reductase.".
- ATP_cone symbol "ATP-cone".
- ATP_cone thumbnail PDB_7r1r_EBI.jpg?width=300.
- ATP_cone wikiPageID "32149638".
- ATP_cone wikiPageLength "2578".
- ATP_cone wikiPageOutDegree "21".
- ATP_cone wikiPageRevisionID "591085709".
- ATP_cone wikiPageWikiLink Allosteric.
- ATP_cone wikiPageWikiLink Allosteric_regulation.
- ATP_cone wikiPageWikiLink Alpha_helix.
- ATP_cone wikiPageWikiLink Binding_(molecular).
- ATP_cone wikiPageWikiLink Category:Protein_domains.
- ATP_cone wikiPageWikiLink Effector_(biology).
- ATP_cone wikiPageWikiLink Enzyme_activity.
- ATP_cone wikiPageWikiLink Enzyme_assay.
- ATP_cone wikiPageWikiLink Enzyme_substrate.
- ATP_cone wikiPageWikiLink Evolution.
- ATP_cone wikiPageWikiLink Evolutionary.
- ATP_cone wikiPageWikiLink Gene_regulation.
- ATP_cone wikiPageWikiLink Hydrophobe.
- ATP_cone wikiPageWikiLink Hydrophobic.
- ATP_cone wikiPageWikiLink Kinase.
- ATP_cone wikiPageWikiLink Kinases.
- ATP_cone wikiPageWikiLink Molecular_binding.
- ATP_cone wikiPageWikiLink Phosphate.
- ATP_cone wikiPageWikiLink Protein.
- ATP_cone wikiPageWikiLink Protein_domain.
- ATP_cone wikiPageWikiLink Protein_subunit.
- ATP_cone wikiPageWikiLink Reductase.
- ATP_cone wikiPageWikiLink Regulation_of_gene_expression.
- ATP_cone wikiPageWikiLink Ribonucleotide.
- ATP_cone wikiPageWikiLink Ribonucleotide_reductase.
- ATP_cone wikiPageWikiLink Substrate_(chemistry).
- ATP_cone wikiPageWikiLink Transcription_(genetics).
- ATP_cone caption "ribonucleotide reductase e441q mutant r1 protein from escherichia coli".
- ATP_cone hasPhotoCollection ATP_cone.
- ATP_cone interpro "IPR005144".
- ATP_cone name "ATP-cone".
- ATP_cone pfam "PF03477".
- ATP_cone scop "7".
- ATP_cone symbol "ATP-cone".
- ATP_cone wikiPageUsesTemplate Template:Infobox_protein_family.
- ATP_cone wikiPageUsesTemplate Template:InterPro_content.
- ATP_cone wikiPageUsesTemplate Template:Orphan.
- ATP_cone wikiPageUsesTemplate Template:Reflist.
- ATP_cone subject Category:Protein_domains.
- ATP_cone type Biomolecule.
- ATP_cone type Protein.
- ATP_cone type Chemical.
- ATP_cone type Domain.
- ATP_cone type Thing.
- ATP_cone type Q206229.
- ATP_cone type Q8054.
- ATP_cone comment "In molecular biology, the ATP-cone is an evolutionarily mobile, ATP-binding regulatory domain which is found in a variety of proteins including ribonucleotide reductases, phosphoglycerate kinases and transcriptional regulators.In ribonucleotide reductase protein R1 from Escherichia coli this domain is located at the N terminus, and is composed mostly of helices.".
- ATP_cone label "ATP cone".
- ATP_cone sameAs m.0gx23j5.
- ATP_cone sameAs Q4654876.
- ATP_cone sameAs Q4654876.
- ATP_cone wasDerivedFrom ATP_cone?oldid=591085709.
- ATP_cone depiction PDB_7r1r_EBI.jpg.
- ATP_cone isPrimaryTopicOf ATP_cone.