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- OTCase_family abstract "In molecular biology, the ATCase/OTCase family is a protein family which contains two related enzymes: aspartate carbamoyltransferase EC 2.1.3.2 and ornithine carbamoyltransferase EC 2.1.3.3. It has been shown that these enzymes are evolutionary related. The predicted secondary structure of both enzymes is similar and there are some regions of sequence similarities. One of these regions includes three residues which have been shown, by crystallographic studies to be implicated in binding the phosphoryl group of carbamoyl phosphate and may also play a role in trimerisation of the molecules. The N-terminal domain is the carbamoyl phosphate binding domain. The C-terminal domain is an aspartate/ornithine-binding domain.Aspartate carbamoyltransferase (ATCase) catalyses the conversion of aspartate and carbamoyl phosphate to carbamoylaspartate, the second step in the de novo biosynthesis of pyrimidine nucleotides. In prokaryotes ATCase consists of two subunits: a catalytic chain (gene pyrB) and a regulatory chain (gene pyrI), while in eukaryotes it is a domain in a multi- functional enzyme (called URA2 in yeast, rudimentary in Drosophila, and CAD in mammals) that also catalyzes other steps of the biosynthesis of pyrimidines.Ornithine carbamoyltransferase (OTCase) catalyses the conversion of ornithine and carbamoyl phosphate to citrulline. In mammals this enzyme participates in the urea cycle and is located in the mitochondrial matrix. In prokaryotes and eukaryotic microorganisms it is involved in the biosynthesis of arginine. In some bacterial species it is also involved in the degradation of arginine (the arginine deaminase pathway).".
- OTCase_family symbol "OTCace".
- OTCase_family symbol "OTCace_N".
- OTCase_family thumbnail PDB_1ml4_EBI.jpg?width=300.
- OTCase_family wikiPageID "34844082".
- OTCase_family wikiPageLength "5518".
- OTCase_family wikiPageOutDegree "44".
- OTCase_family wikiPageRevisionID "590710339".
- OTCase_family wikiPageWikiLink Arginine.
- OTCase_family wikiPageWikiLink Aspartate_carbamoyltransferase.
- OTCase_family wikiPageWikiLink Aspartic_acid.
- OTCase_family wikiPageWikiLink Bacteria.
- OTCase_family wikiPageWikiLink Binding_(molecular).
- OTCase_family wikiPageWikiLink Biomolecular_structure.
- OTCase_family wikiPageWikiLink Biosynthesis.
- OTCase_family wikiPageWikiLink C-terminal.
- OTCase_family wikiPageWikiLink C-terminus.
- OTCase_family wikiPageWikiLink Carbamoyl_phosphate.
- OTCase_family wikiPageWikiLink Catalysis.
- OTCase_family wikiPageWikiLink Catalytic.
- OTCase_family wikiPageWikiLink Catalyze.
- OTCase_family wikiPageWikiLink Category:Protein_domains.
- OTCase_family wikiPageWikiLink Citrulline.
- OTCase_family wikiPageWikiLink Drosophila.
- OTCase_family wikiPageWikiLink Enzyme.
- OTCase_family wikiPageWikiLink Enzymes.
- OTCase_family wikiPageWikiLink Eukaryote.
- OTCase_family wikiPageWikiLink Eukaryotes.
- OTCase_family wikiPageWikiLink Eukaryotic.
- OTCase_family wikiPageWikiLink Evolution.
- OTCase_family wikiPageWikiLink Mammal.
- OTCase_family wikiPageWikiLink Mammals.
- OTCase_family wikiPageWikiLink Microorganism.
- OTCase_family wikiPageWikiLink Microorganisms.
- OTCase_family wikiPageWikiLink Molecular_binding.
- OTCase_family wikiPageWikiLink Molecule.
- OTCase_family wikiPageWikiLink N-terminal.
- OTCase_family wikiPageWikiLink N-terminus.
- OTCase_family wikiPageWikiLink Nucleotide.
- OTCase_family wikiPageWikiLink Ornithine.
- OTCase_family wikiPageWikiLink Ornithine_carbamoyltransferase.
- OTCase_family wikiPageWikiLink Ornithine_transcarbamylase.
- OTCase_family wikiPageWikiLink Phosphate.
- OTCase_family wikiPageWikiLink Prokaryote.
- OTCase_family wikiPageWikiLink Prokaryotes.
- OTCase_family wikiPageWikiLink Protein_domain.
- OTCase_family wikiPageWikiLink Protein_family.
- OTCase_family wikiPageWikiLink Pyrimidine.
- OTCase_family wikiPageWikiLink Secondary_structure.
- OTCase_family wikiPageWikiLink Sequence_(biology).
- OTCase_family wikiPageWikiLink Species.
- OTCase_family wikiPageWikiLink Trimer_(chemistry).
- OTCase_family wikiPageWikiLink Trimerization.
- OTCase_family wikiPageWikiLink Urea_cycle.
- OTCase_family wikiPageWikiLink Wikt:de_novo.
- OTCase_family wikiPageWikiLink X-ray_crystallography.
- OTCase_family wikiPageWikiLink Yeast.
- OTCase_family caption "the pala-liganded aspartate transcarbamoylase catalytic subunit from pyrococcus abyssi".
- OTCase_family hasPhotoCollection OTCase_family.
- OTCase_family interpro "IPR006132".
- OTCase_family name "Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain".
- OTCase_family name "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain".
- OTCase_family pfam "PF00185".
- OTCase_family pfam "PF02729".
- OTCase_family prosite "PDOC00091".
- OTCase_family scop "1".
- OTCase_family symbol "OTCace".
- OTCase_family symbol "OTCace_N".
- OTCase_family wikiPageUsesTemplate Template:EC_number.
- OTCase_family wikiPageUsesTemplate Template:Infobox_protein_family.
- OTCase_family wikiPageUsesTemplate Template:InterPro_content.
- OTCase_family wikiPageUsesTemplate Template:Orphan.
- OTCase_family wikiPageUsesTemplate Template:Reflist.
- OTCase_family subject Category:Protein_domains.
- OTCase_family hypernym Family.
- OTCase_family type Article.
- OTCase_family type Biomolecule.
- OTCase_family type Protein.
- OTCase_family type Article.
- OTCase_family type Chemical.
- OTCase_family type Domain.
- OTCase_family type Thing.
- OTCase_family type Q206229.
- OTCase_family type Q8054.
- OTCase_family comment "In molecular biology, the ATCase/OTCase family is a protein family which contains two related enzymes: aspartate carbamoyltransferase EC 2.1.3.2 and ornithine carbamoyltransferase EC 2.1.3.3. It has been shown that these enzymes are evolutionary related. The predicted secondary structure of both enzymes is similar and there are some regions of sequence similarities.".
- OTCase_family label "ATCase/OTCase family".
- OTCase_family sameAs m.0j45glm.
- OTCase_family sameAs Q4654613.
- OTCase_family sameAs Q4654613.
- OTCase_family wasDerivedFrom OTCase_family?oldid=590710339.
- OTCase_family depiction PDB_1ml4_EBI.jpg.
- OTCase_family isPrimaryTopicOf OTCase_family.