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- ASCL1 abstract "Achaete-scute homolog 1 is a protein that in humans is encoded by the ASCL1 gene. Because it was discovered subsequent to studies on its homolog in Drosophila, the Achaete-scute complex, it was originally named MASH-1 for mammalian achaete scute homolog-1.This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. It is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests that it may also play a role in tumor formation.".
- ASCL1 entrezgene "429".
- ASCL1 wikiPageID "14771355".
- ASCL1 wikiPageLength "12474".
- ASCL1 wikiPageOutDegree "36".
- ASCL1 wikiPageRevisionID "659776867".
- ASCL1 wikiPageWikiLink Achaete-scute_complex.
- ASCL1 wikiPageWikiLink Adrenal_gland.
- ASCL1 wikiPageWikiLink Adrenal_glands.
- ASCL1 wikiPageWikiLink Aorta.
- ASCL1 wikiPageWikiLink Autonomic_nervous_system.
- ASCL1 wikiPageWikiLink BHLH.
- ASCL1 wikiPageWikiLink Basic_helix-loop-helix.
- ASCL1 wikiPageWikiLink Category:Transcription_factors.
- ASCL1 wikiPageWikiLink DNA.
- ASCL1 wikiPageWikiLink Delta_(protein).
- ASCL1 wikiPageWikiLink Drosophila.
- ASCL1 wikiPageWikiLink E-box.
- ASCL1 wikiPageWikiLink E_box.
- ASCL1 wikiPageWikiLink Embryo.
- ASCL1 wikiPageWikiLink Ganglia.
- ASCL1 wikiPageWikiLink Ganglion.
- ASCL1 wikiPageWikiLink Gene.
- ASCL1 wikiPageWikiLink Hairless.
- ASCL1 wikiPageWikiLink Lateral_inhibition.
- ASCL1 wikiPageWikiLink Lung_cancer.
- ASCL1 wikiPageWikiLink Mastermind_(protein).
- ASCL1 wikiPageWikiLink Medullary_thyroid_cancer.
- ASCL1 wikiPageWikiLink Mitosis.
- ASCL1 wikiPageWikiLink Mitotic_division.
- ASCL1 wikiPageWikiLink Myocyte-specific_enhancer_factor_2A.
- ASCL1 wikiPageWikiLink Nervous_system.
- ASCL1 wikiPageWikiLink Neural_tube.
- ASCL1 wikiPageWikiLink Neuroblast.
- ASCL1 wikiPageWikiLink Neuroblasts.
- ASCL1 wikiPageWikiLink Neuroepithelial_cell.
- ASCL1 wikiPageWikiLink Neuroepithelium.
- ASCL1 wikiPageWikiLink Neuron.
- ASCL1 wikiPageWikiLink Neurons.
- ASCL1 wikiPageWikiLink Notch_receptor.
- ASCL1 wikiPageWikiLink Notch_signaling_pathway.
- ASCL1 wikiPageWikiLink Protease.
- ASCL1 wikiPageWikiLink Protein.
- ASCL1 wikiPageWikiLink Protein-protein_interaction.
- ASCL1 wikiPageWikiLink Protein_dimer.
- ASCL1 wikiPageWikiLink Protein_dimerization.
- ASCL1 wikiPageWikiLink Protein–protein_interaction.
- ASCL1 wikiPageWikiLink Proteolytic_cleavage.
- ASCL1 wikiPageWikiLink Sympathetic_chain.
- ASCL1 wikiPageWikiLink Sympathetic_trunk.
- ASCL1 wikiPageWikiLink Transcription_regulator.
- ASCL1 wikiPageWikiLink Transcriptional_regulation.
- ASCL1 wikiPageWikiLinkText "ASCL1".
- ASCL1 wikiPageWikiLinkText "ASCL1/Mash1".
- ASCL1 wikiPageWikiLinkText "Ascl1".
- ASCL1 wikiPageWikiLinkText "MASH1".
- ASCL1 wikiPageWikiLinkText "Mash".
- ASCL1 wikiPageWikiLinkText "Mash1".
- ASCL1 wikiPageWikiLinkText "mash1".
- ASCL1 hasPhotoCollection ASCL1.
- ASCL1 inhibits Notch_signaling_pathway.
- ASCL1 requireManualInspection "no".
- ASCL1 summaryText "This gene encodes a member of the basic helix-loop-helix family of transcription factors. The protein activates transcription by binding to the E box . Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. It is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests that it may also play a role in tumor formation.".
- ASCL1 updateCitations "yes".
- ASCL1 updatePage "yes".
- ASCL1 updateProteinBox "yes".
- ASCL1 updateSummary "yes".
- ASCL1 wikiPageUsesTemplate Template:MeshName.
- ASCL1 wikiPageUsesTemplate Template:NLM_content.
- ASCL1 wikiPageUsesTemplate Template:PBB.
- ASCL1 wikiPageUsesTemplate Template:PBB_Controls.
- ASCL1 wikiPageUsesTemplate Template:PBB_Further_reading.
- ASCL1 wikiPageUsesTemplate Template:PBB_Summary.
- ASCL1 wikiPageUsesTemplate Template:Refbegin.
- ASCL1 wikiPageUsesTemplate Template:Refend.
- ASCL1 wikiPageUsesTemplate Template:Reflist.
- ASCL1 wikiPageUsesTemplate Template:Regulome.
- ASCL1 wikiPageUsesTemplate Template:Transcription_factors.
- ASCL1 subject Category:Transcription_factors.
- ASCL1 hypernym Protein.
- ASCL1 type Article.
- ASCL1 type Biomolecule.
- ASCL1 type Protein.
- ASCL1 type Article.
- ASCL1 type Factor.
- ASCL1 type Institute.
- ASCL1 type Source.
- ASCL1 type Thing.
- ASCL1 type Q206229.
- ASCL1 type Q8054.
- ASCL1 comment "Achaete-scute homolog 1 is a protein that in humans is encoded by the ASCL1 gene. Because it was discovered subsequent to studies on its homolog in Drosophila, the Achaete-scute complex, it was originally named MASH-1 for mammalian achaete scute homolog-1.This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3').".
- ASCL1 label "ASCL1".
- ASCL1 sameAs m.03gxfw2.
- ASCL1 sameAs Q4654121.
- ASCL1 sameAs Q4654121.
- ASCL1 wasDerivedFrom ASCL1?oldid=659776867.
- ASCL1 isPrimaryTopicOf ASCL1.