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- ARID_domain abstract "In molecular biology, the ARID domain (AT-rich interaction domain; also known as BRIGHT domain)) is a protein domain that binds to DNA. ARID domain-containing proteins are found in fungi and invertebrate and vertebrate metazoans. ARID-encoding genes are involved in a variety of biological processes including embryonic development, cell lineage gene regulation and cell cycle control. Although the specific roles of this domain and of ARID-containing proteins in transcriptional regulation are yet to be elucidated, they include both positive and negative transcriptional regulation and a likely involvement in the modification of chromatin structure. The basic structure of the ARID domain appears to be a series of six alpha-helices separated by beta-strands, loops, or turns, but the structured region may extend to an additional helix at either or both ends of the basic six. Based on primary sequence homology, they can be partitioned into three structural classes: Minimal ARID proteins that consist of a core domain formed by six alpha helices; ARID proteins that supplement the core domain with an N-terminal alpha-helix; and Extended-ARID proteins, which contain the core domain and additional alpha-helices at their N- and C-termini.The human SWI-SNF complex protein p270 is an ARID family member with non-sequence-specific DNA binding activity. The ARID consensus and other structural features are common to both p270 and yeast SWI1, suggesting that p270 is a human counterpart of SWI1. The approximately 100-residue ARID sequence is present in a series of proteins strongly implicated in the regulation of cell growth, development, and tissue-specific gene expression. Although about a dozen ARID proteins can be identified from database searches, to date, only Bright (a regulator of B-cell-specific gene expression), dead ringer (a Drosophila melanogaster gene product required for normal development), and MRF-2 (which represses expression from the Cytomegalovirus enhancer) have been analyzed directly with regard to their DNA binding properties. Each binds preferentially to AT-rich sites. In contrast, p270 shows no sequence preference in its DNA binding activity, thereby demonstrating that AT-rich binding is not an intrinsic property of ARID domains and that ARID family proteins may be involved in a wider range of DNA interactions.".
- ARID_domain symbol "ARID".
- ARID_domain thumbnail PDB_1ig6_EBI.jpg?width=300.
- ARID_domain wikiPageID "32148163".
- ARID_domain wikiPageLength "4379".
- ARID_domain wikiPageOutDegree "41".
- ARID_domain wikiPageRevisionID "590651760".
- ARID_domain wikiPageWikiLink Alpha-helices.
- ARID_domain wikiPageWikiLink Alpha_helix.
- ARID_domain wikiPageWikiLink Animal.
- ARID_domain wikiPageWikiLink Binding_(molecular).
- ARID_domain wikiPageWikiLink Biology.
- ARID_domain wikiPageWikiLink Biomolecular_structure.
- ARID_domain wikiPageWikiLink Category:Protein_domains.
- ARID_domain wikiPageWikiLink Cell_(biology).
- ARID_domain wikiPageWikiLink Cell_cycle.
- ARID_domain wikiPageWikiLink Chromatin.
- ARID_domain wikiPageWikiLink Cytomegalovirus.
- ARID_domain wikiPageWikiLink DNA.
- ARID_domain wikiPageWikiLink Drosophila.
- ARID_domain wikiPageWikiLink Fungus.
- ARID_domain wikiPageWikiLink Gene.
- ARID_domain wikiPageWikiLink Gene_expression.
- ARID_domain wikiPageWikiLink Gene_regulation.
- ARID_domain wikiPageWikiLink Genes.
- ARID_domain wikiPageWikiLink Helix.
- ARID_domain wikiPageWikiLink Homo_sapiens.
- ARID_domain wikiPageWikiLink Human.
- ARID_domain wikiPageWikiLink Invertebrate.
- ARID_domain wikiPageWikiLink Metazoan.
- ARID_domain wikiPageWikiLink Molecular_binding.
- ARID_domain wikiPageWikiLink Molecular_biology.
- ARID_domain wikiPageWikiLink Multiprotein_complex.
- ARID_domain wikiPageWikiLink Nucleic_acid_sequence.
- ARID_domain wikiPageWikiLink Nucleotide_sequence.
- ARID_domain wikiPageWikiLink Product_(chemistry).
- ARID_domain wikiPageWikiLink Protein.
- ARID_domain wikiPageWikiLink Protein_complex.
- ARID_domain wikiPageWikiLink Protein_domain.
- ARID_domain wikiPageWikiLink Proteins.
- ARID_domain wikiPageWikiLink Regulation.
- ARID_domain wikiPageWikiLink Regulation_of_gene_expression.
- ARID_domain wikiPageWikiLink SNF.
- ARID_domain wikiPageWikiLink Saccharomyces_cerevisiae.
- ARID_domain wikiPageWikiLink Secondary_structure.
- ARID_domain wikiPageWikiLink Sequence.
- ARID_domain wikiPageWikiLink Sequence_(biology).
- ARID_domain wikiPageWikiLink Transcription_(genetics).
- ARID_domain wikiPageWikiLink Transcriptional_regulation.
- ARID_domain wikiPageWikiLink Vertebrate.
- ARID_domain wikiPageWikiLinkText "ARID domain".
- ARID_domain wikiPageWikiLinkText "ARID".
- ARID_domain caption "human mrf-2 domain, nmr, 11 structures".
- ARID_domain hasPhotoCollection ARID_domain.
- ARID_domain interpro "IPR001606".
- ARID_domain name "ARID".
- ARID_domain pfam "PF01388".
- ARID_domain scop "1".
- ARID_domain symbol "ARID".
- ARID_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- ARID_domain wikiPageUsesTemplate Template:InterPro_content.
- ARID_domain wikiPageUsesTemplate Template:Reflist.
- ARID_domain subject Category:Protein_domains.
- ARID_domain hypernym Domain.
- ARID_domain type Biomolecule.
- ARID_domain type Protein.
- ARID_domain type Chemical.
- ARID_domain type Domain.
- ARID_domain type Thing.
- ARID_domain type Q206229.
- ARID_domain type Q8054.
- ARID_domain comment "In molecular biology, the ARID domain (AT-rich interaction domain; also known as BRIGHT domain)) is a protein domain that binds to DNA. ARID domain-containing proteins are found in fungi and invertebrate and vertebrate metazoans. ARID-encoding genes are involved in a variety of biological processes including embryonic development, cell lineage gene regulation and cell cycle control.".
- ARID_domain label "ARID domain".
- ARID_domain sameAs m.0gwz8rj.
- ARID_domain sameAs Q4653778.
- ARID_domain sameAs Q4653778.
- ARID_domain wasDerivedFrom ARID_domain?oldid=590651760.
- ARID_domain depiction PDB_1ig6_EBI.jpg.
- ARID_domain isPrimaryTopicOf ARID_domain.