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- AP_site abstract "In biochemistry and molecular genetics, an AP site (apurinic/apyrimidinic site), also known as an abasic site, is a location in DNA (also in RNA but much less likely) that has neither a purine nor a pyrimidine base, either spontaneously or due to DNA damage. It has been estimated that under physiological conditions 10,000 apurinic sites and 500 apyrimidinic may be generated in a cell daily.AP sites can be formed by spontaneous depurination, but also occur as intermediates in base excision repair. In this process, a DNA glycosylase recognizes a damaged base and cleaves the N-glycosidic bond to release the base, leaving an AP site. A variety of glycosylases that recognize different types of damage exist, including oxidized or methylated bases, or uracil in RNA. The AP site can then be cleaved by an AP endonuclease, leaving 3' hydroxyl and 5' deoxyribosephosphate termini (see DNA structure). In alternative fashion, bifunctional glycosylase-lyases can cleave the AP site, leaving a 5' phosphate adjacent to a 3' α,β-unsaturated aldehyde. Both mechanisms form a single-strand break, which is then repaired by either short-patch or long-patch base excision repair.If left unrepaired, AP sites can lead to mutation during semiconservative replication. They can cause replication fork stalling and are bypassed by translesion synthesis. In E. coli, adenine is preferentially inserted across from AP sites, known as the "A rule". The situation is more complex in higher eukaryotes, with different nucleotides showing a preference depending on the organism and experimental conditions.".
- AP_site wikiPageID "1928941".
- AP_site wikiPageLength "2237".
- AP_site wikiPageOutDegree "21".
- AP_site wikiPageRevisionID "677265296".
- AP_site wikiPageWikiLink AP_endonuclease.
- AP_site wikiPageWikiLink Base_excision_repair.
- AP_site wikiPageWikiLink Biochemistry.
- AP_site wikiPageWikiLink Category:DNA_repair.
- AP_site wikiPageWikiLink Category:Molecular_genetics.
- AP_site wikiPageWikiLink DNA.
- AP_site wikiPageWikiLink DNA_damage.
- AP_site wikiPageWikiLink DNA_glycosylase.
- AP_site wikiPageWikiLink DNA_repair.
- AP_site wikiPageWikiLink DNA_replication.
- AP_site wikiPageWikiLink DNA_structure.
- AP_site wikiPageWikiLink Depurination.
- AP_site wikiPageWikiLink Escherichia_coli.
- AP_site wikiPageWikiLink Molecular_genetics.
- AP_site wikiPageWikiLink Mutation.
- AP_site wikiPageWikiLink Nucleic_acid_structure.
- AP_site wikiPageWikiLink Purine.
- AP_site wikiPageWikiLink Pyrimidine.
- AP_site wikiPageWikiLink RNA.
- AP_site wikiPageWikiLink Replication_fork.
- AP_site wikiPageWikiLink Semiconservative_replication.
- AP_site wikiPageWikiLink Uracil.
- AP_site wikiPageWikiLinkText "AP site".
- AP_site wikiPageWikiLinkText "abasic site".
- AP_site hasPhotoCollection AP_site.
- AP_site wikiPageUsesTemplate Template:Biochem-stub.
- AP_site wikiPageUsesTemplate Template:Genetics-stub.
- AP_site subject Category:DNA_repair.
- AP_site subject Category:Molecular_genetics.
- AP_site hypernym Location.
- AP_site type Place.
- AP_site type Process.
- AP_site comment "In biochemistry and molecular genetics, an AP site (apurinic/apyrimidinic site), also known as an abasic site, is a location in DNA (also in RNA but much less likely) that has neither a purine nor a pyrimidine base, either spontaneously or due to DNA damage.".
- AP_site label "AP site".
- AP_site sameAs AP-Stelle.
- AP_site sameAs Site_AP.
- AP_site sameAs Miejsce_AP.
- AP_site sameAs m.066vrb.
- AP_site sameAs AP-site.
- AP_site sameAs Q176783.
- AP_site sameAs Q176783.
- AP_site sameAs AP位點.
- AP_site wasDerivedFrom AP_site?oldid=677265296.
- AP_site isPrimaryTopicOf AP_site.