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- AP_endonuclease abstract "Apurinic/apyrimidinic (AP) endonuclease (BRENDA = 4.2.99.18) is an enzyme that is involved in the DNA base excision repair pathway (BER). Its main role in the repair of damaged or mismatched nucleotides in DNA is to create a nick in the phosphodiester backbone of the AP site created when DNA glycosylase removes the damaged base.There are four types of AP endonucleases that have been classified according to their sites of incision. Class I and class II AP endonucleases incise DNA at the phosphate groups 3´ and 5´ to the baseless site leaving 3´-OH and 5´-phosphate termini. Class III and class IV AP endonucleases also cleave DNA at the phosphate groups 3´ and 5´to the baseless site, but they generate a 3´-phosphate and a 5´-OH.Human AP Endonuclease (APE1), like most AP endonucleases, is of class II and requires an Mg2+ in its active site in order to carry out its role in base excision repair. The yeast homolog of this enzyme is APN1.".
- AP_endonuclease thumbnail ApEndonuclease1.jpg?width=300.
- AP_endonuclease wikiPageExternalLink AP_endonuclease.html.
- AP_endonuclease wikiPageExternalLink PDOC00598.
- AP_endonuclease wikiPageExternalLink PDOC00599.
- AP_endonuclease wikiPageExternalLink 3405.
- AP_endonuclease wikiPageExternalLink 41715.
- AP_endonuclease wikiPageID "2953206".
- AP_endonuclease wikiPageLength "8029".
- AP_endonuclease wikiPageOutDegree "40".
- AP_endonuclease wikiPageRevisionID "594660999".
- AP_endonuclease wikiPageWikiLink AP_site.
- AP_endonuclease wikiPageWikiLink Acid_dissociation_constant.
- AP_endonuclease wikiPageWikiLink Active_site.
- AP_endonuclease wikiPageWikiLink Alanine.
- AP_endonuclease wikiPageWikiLink Alpha_helix.
- AP_endonuclease wikiPageWikiLink Amino_acid.
- AP_endonuclease wikiPageWikiLink Arginine.
- AP_endonuclease wikiPageWikiLink Asparagine.
- AP_endonuclease wikiPageWikiLink Aspartic_acid.
- AP_endonuclease wikiPageWikiLink BRENDA.
- AP_endonuclease wikiPageWikiLink Base_excision_repair.
- AP_endonuclease wikiPageWikiLink Category:Enzymes.
- AP_endonuclease wikiPageWikiLink DNA.
- AP_endonuclease wikiPageWikiLink DNA_glycosylase.
- AP_endonuclease wikiPageWikiLink Endonuclease.
- AP_endonuclease wikiPageWikiLink Enzyme.
- AP_endonuclease wikiPageWikiLink Glycine.
- AP_endonuclease wikiPageWikiLink Histidine.
- AP_endonuclease wikiPageWikiLink Hydrogen_bond.
- AP_endonuclease wikiPageWikiLink Hydrogen_bonding.
- AP_endonuclease wikiPageWikiLink Hydrophobe.
- AP_endonuclease wikiPageWikiLink Hydrophobic.
- AP_endonuclease wikiPageWikiLink Leucine.
- AP_endonuclease wikiPageWikiLink Lucanthone.
- AP_endonuclease wikiPageWikiLink Lysine.
- AP_endonuclease wikiPageWikiLink Methionine.
- AP_endonuclease wikiPageWikiLink Nucleophile.
- AP_endonuclease wikiPageWikiLink Nucleotide.
- AP_endonuclease wikiPageWikiLink Nucleotides.
- AP_endonuclease wikiPageWikiLink PH.
- AP_endonuclease wikiPageWikiLink PROSITE.
- AP_endonuclease wikiPageWikiLink Phenylalanine.
- AP_endonuclease wikiPageWikiLink Phosphodiester.
- AP_endonuclease wikiPageWikiLink Phosphodiester_bond.
- AP_endonuclease wikiPageWikiLink Tryptophan.
- AP_endonuclease wikiPageWikiLink Tyrosine.
- AP_endonuclease wikiPageWikiLink Α-helix.
- AP_endonuclease wikiPageWikiLink File:APE1DNABend.jpg.
- AP_endonuclease wikiPageWikiLink File:APE1activelabeled.JPG.
- AP_endonuclease wikiPageWikiLink File:ApEndonuclease1.jpg.
- AP_endonuclease wikiPageWikiLink File:Lucanthone.png.
- AP_endonuclease wikiPageWikiLink File:MechanismAPE1colour_2.svg.
- AP_endonuclease wikiPageWikiLinkText "AP endonuclease".
- AP_endonuclease wikiPageWikiLinkText "apurinic or apyrimidinic endonuclease I".
- AP_endonuclease hasPhotoCollection AP_endonuclease.
- AP_endonuclease wikiPageUsesTemplate Template:Reflist.
- AP_endonuclease subject Category:Enzymes.
- AP_endonuclease hypernym Enzyme.
- AP_endonuclease type Protein.
- AP_endonuclease comment "Apurinic/apyrimidinic (AP) endonuclease (BRENDA = 4.2.99.18) is an enzyme that is involved in the DNA base excision repair pathway (BER). Its main role in the repair of damaged or mismatched nucleotides in DNA is to create a nick in the phosphodiester backbone of the AP site created when DNA glycosylase removes the damaged base.There are four types of AP endonucleases that have been classified according to their sites of incision.".
- AP_endonuclease label "AP endonuclease".
- AP_endonuclease sameAs AP_endonucléase.
- AP_endonuclease sameAs Endonuclease_AP.
- AP_endonuclease sameAs m.08fvb3.
- AP_endonuclease sameAs Q4653506.
- AP_endonuclease sameAs Q4653506.
- AP_endonuclease wasDerivedFrom AP_endonuclease?oldid=594660999.
- AP_endonuclease depiction ApEndonuclease1.jpg.
- AP_endonuclease isPrimaryTopicOf AP_endonuclease.