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- AN2728 abstract "AN2728 is a boron-containing drug candidate that as of 2015 was under development by Anacor Pharmaceuticals for the topical treatment of psoriasis and atopic dermatitis (atopic eczema). It is a phosphodiesterase-4 inhibitor, mainly acting on phosphodiesterase 4B (PDE4B). Chemically, AN2728 is a phenoxybenoxaborole; the boron atom is essential for its binding activity. Inhibition of PDE4B appears to suppress the release of tumor necrosis factor alpha (TNFα), interleukin-12 (IL-12), IL-23 and other cytokines, proteins believed to be involved in the immune response and inflammation. As of 2015 Anacor was conducting a Phase 3 clinical trial for the treatment of atopic dermatitis, and some Phase 2 trials had been completed for the treatment of psoriasis.".
- AN2728 thumbnail AN-2728.svg?width=300.
- AN2728 wikiPageID "46181068".
- AN2728 wikiPageLength "3453".
- AN2728 wikiPageOutDegree "20".
- AN2728 wikiPageRevisionID "671463737".
- AN2728 wikiPageWikiLink Anacor.
- AN2728 wikiPageWikiLink Atopic_dermatitis.
- AN2728 wikiPageWikiLink Boron.
- AN2728 wikiPageWikiLink Category:Phosphodiesterase_inhibitors.
- AN2728 wikiPageWikiLink Cytokine.
- AN2728 wikiPageWikiLink Cytokines.
- AN2728 wikiPageWikiLink IL-23.
- AN2728 wikiPageWikiLink Interleukin-12.
- AN2728 wikiPageWikiLink Interleukin_12.
- AN2728 wikiPageWikiLink PDE4B.
- AN2728 wikiPageWikiLink Phases_of_clinical_research.
- AN2728 wikiPageWikiLink Phosphodiesterase.
- AN2728 wikiPageWikiLink Phosphodiesterase-4_inhibitor.
- AN2728 wikiPageWikiLink Phosphodiesterase_inhibitor.
- AN2728 wikiPageWikiLink Psoriasis.
- AN2728 wikiPageWikiLink Tumor_necrosis_factor_alpha.
- AN2728 wikiPageWikiLinkText "AN2728".
- AN2728 b "1".
- AN2728 c "14".
- AN2728 chemspiderid "24701949".
- AN2728 drugbank "DB05219".
- AN2728 h "10".
- AN2728 hasPhotoCollection AN2728.
- AN2728 legalStatus "Investigational".
- AN2728 molecularWeight "251.0451".
- AN2728 n "1".
- AN2728 o "3".
- AN2728 pubchem "44591583".
- AN2728 routesOfAdministration "Topical".
- AN2728 smiles "N#CC1=CC=CC=C1".
- AN2728 stdinchi "1".
- AN2728 stdinchikey "USZAGAREISWJDP-UHFFFAOYSA-N".
- AN2728 width "200".
- AN2728 wikiPageUsesTemplate Template:Infobox_drug.
- AN2728 wikiPageUsesTemplate Template:Reflist.
- AN2728 subject Category:Phosphodiesterase_inhibitors.
- AN2728 hypernym Candidate.
- AN2728 type ChemicalSubstance.
- AN2728 type Drug.
- AN2728 type Person.
- AN2728 type ChemicalObject.
- AN2728 type Thing.
- AN2728 type Q8386.
- AN2728 comment "AN2728 is a boron-containing drug candidate that as of 2015 was under development by Anacor Pharmaceuticals for the topical treatment of psoriasis and atopic dermatitis (atopic eczema). It is a phosphodiesterase-4 inhibitor, mainly acting on phosphodiesterase 4B (PDE4B). Chemically, AN2728 is a phenoxybenoxaborole; the boron atom is essential for its binding activity.".
- AN2728 label "AN2728".
- AN2728 sameAs m.0138gmsp.
- AN2728 wasDerivedFrom AN2728?oldid=671463737.
- AN2728 depiction AN-2728.svg.
- AN2728 isPrimaryTopicOf AN2728.