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- ALX3_(gene) abstract "The ALX3 gene, also known as aristaless-like homeobox 3, is a protein coding gene that provides instructions to build a protein which is a member of the homeobox protein family. This grouping regulates patterns of anatomical development. The gene encodes a nuclear protein that functions as a transcription regulator involved in cell-type differentiation and development.The ALX3 protein, encoded by the gene, is a transcription factor, meaning that it binds to DNA and obtains control over the action of other genes. The ALX3 protein specifically controls genes that regulate cell growth, proliferation, and migration. This protein is essential for the development of the head and face, specifically the nose. This event begins around the fourth week of development.At least 7 mutations in the ALX3 gene are known to cause frontonasal dysplasia. The mutations eliminate the function of the ALX3 protein, resulting in decreased ability to bind to DNA. The loss of regulatory function results in uncontrolled cell proliferation and migration during fetal development. One particular form of the disorder, called frontonasal dysplasia type 1, presents with abnormal development of structures in the middle of the face. The most common malformation of this defect is a cleft in the nose, lip, and palate.".
- ALX3_(gene) wikiPageID "46421404".
- ALX3_(gene) wikiPageLength "2629".
- ALX3_(gene) wikiPageOutDegree "23".
- ALX3_(gene) wikiPageRevisionID "665516485".
- ALX3_(gene) wikiPageWikiLink Anatomy.
- ALX3_(gene) wikiPageWikiLink Category:Human_genes.
- ALX3_(gene) wikiPageWikiLink Cell_(biology).
- ALX3_(gene) wikiPageWikiLink Cell_growth.
- ALX3_(gene) wikiPageWikiLink Cell_migration.
- ALX3_(gene) wikiPageWikiLink Cell_proliferation.
- ALX3_(gene) wikiPageWikiLink Cleft_lip.
- ALX3_(gene) wikiPageWikiLink Cleft_lip_and_palate.
- ALX3_(gene) wikiPageWikiLink Cleft_nose.
- ALX3_(gene) wikiPageWikiLink Cleft_palate.
- ALX3_(gene) wikiPageWikiLink DNA.
- ALX3_(gene) wikiPageWikiLink Face.
- ALX3_(gene) wikiPageWikiLink Fetal_development.
- ALX3_(gene) wikiPageWikiLink Frontonasal_dysplasia.
- ALX3_(gene) wikiPageWikiLink Gene.
- ALX3_(gene) wikiPageWikiLink Gestation.
- ALX3_(gene) wikiPageWikiLink Head.
- ALX3_(gene) wikiPageWikiLink Head_(anatomy).
- ALX3_(gene) wikiPageWikiLink Homeobox.
- ALX3_(gene) wikiPageWikiLink Mutation.
- ALX3_(gene) wikiPageWikiLink Nose.
- ALX3_(gene) wikiPageWikiLink Nuclear_protein.
- ALX3_(gene) wikiPageWikiLink Prenatal_development.
- ALX3_(gene) wikiPageWikiLink Protein.
- ALX3_(gene) wikiPageWikiLink Transcription_(genetics).
- ALX3_(gene) wikiPageWikiLink Transcription_factor.
- ALX3_(gene) wikiPageWikiLinkText "ALX3 gene".
- ALX3_(gene) hasPhotoCollection ALX3_(gene).
- ALX3_(gene) wikiPageUsesTemplate Template:Ref_improve.
- ALX3_(gene) wikiPageUsesTemplate Template:Reflist.
- ALX3_(gene) subject Category:Human_genes.
- ALX3_(gene) hypernym Protein.
- ALX3_(gene) type Protein.
- ALX3_(gene) comment "The ALX3 gene, also known as aristaless-like homeobox 3, is a protein coding gene that provides instructions to build a protein which is a member of the homeobox protein family. This grouping regulates patterns of anatomical development.".
- ALX3_(gene) label "ALX3 (gene)".
- ALX3_(gene) sameAs m.0136znd0.
- ALX3_(gene) wasDerivedFrom ALX3_(gene)?oldid=665516485.
- ALX3_(gene) isPrimaryTopicOf ALX3_(gene).