Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/ADP_ribosylation_factor> ?p ?o }
- ADP_ribosylation_factor abstract "ADP Ribosylation Factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mammalian cells. Although ARFs are soluble, they generally associate with membranes because of N-terminus myristoylation. They function as regulators of vesicular traffic and actin remodelling. The small ADP ribosylation factor (Arf) GTP-binding proteins are major regulators of vesicle biogenesis in intracellular traffic. They are the founding members of a growing family that includes Arl (Arf-like), Arp (Arf-related proteins) and the remotely related Sar (Secretion-associated and Ras-related) proteins. Arf proteins cycle between inactive GDP-bound and active GTP-bound forms that bind selectively to effectors. The classical structural GDP/GTP switch is characterised by conformational changes at the so-called switch 1 and switch 2 regions, which bind tightly to the gamma-phosphate of GTP but poorly or not at all to the GDP nucleotide. Structural studies of Arf1 and Arf6 have revealed that although these proteins feature the switch 1 and 2 conformational changes, they depart from other small GTP-binding proteins in that they use an additional, unique switch to propagate structural information from one side of the protein to the other.The GDP/GTP structural cycles of human Arf1 and Arf6 feature a unique conformational change that affects the beta2beta3 strands connecting switch 1 and switch 2 (interswitch) and also the amphipathic helical N-terminus. In GDP-bound Arf1 and Arf6, the interswitch is retracted and forms a pocket to which the N-terminal helix binds, the latter serving as a molecular hasp to maintain the inactive conformation. In the GTP-bound form of these proteins, the interswitch undergoes a two-residue register shift that pulls switch 1 and switch 2 up, restoring an active conformation that can bind GTP. In this conformation, the interswitch projects out of the protein and extrudes the N-terminal hasp by occluding its binding pocket.".
- ADP_ribosylation_factor symbol "Arf".
- ADP_ribosylation_factor thumbnail 1ksg_opm.png?width=300.
- ADP_ribosylation_factor wikiPageID "4668380".
- ADP_ribosylation_factor wikiPageLength "7587".
- ADP_ribosylation_factor wikiPageOutDegree "58".
- ADP_ribosylation_factor wikiPageRevisionID "681640966".
- ADP_ribosylation_factor wikiPageWikiLink ARF1.
- ADP_ribosylation_factor wikiPageWikiLink ARF3.
- ADP_ribosylation_factor wikiPageWikiLink ARF4.
- ADP_ribosylation_factor wikiPageWikiLink ARF5.
- ADP_ribosylation_factor wikiPageWikiLink ARF6.
- ADP_ribosylation_factor wikiPageWikiLink ARFRP1.
- ADP_ribosylation_factor wikiPageWikiLink ARL1.
- ADP_ribosylation_factor wikiPageWikiLink ARL10.
- ADP_ribosylation_factor wikiPageWikiLink ARL11.
- ADP_ribosylation_factor wikiPageWikiLink ARL13A.
- ADP_ribosylation_factor wikiPageWikiLink ARL13B.
- ADP_ribosylation_factor wikiPageWikiLink ARL14.
- ADP_ribosylation_factor wikiPageWikiLink ARL15.
- ADP_ribosylation_factor wikiPageWikiLink ARL16.
- ADP_ribosylation_factor wikiPageWikiLink ARL17.
- ADP_ribosylation_factor wikiPageWikiLink ARL2.
- ADP_ribosylation_factor wikiPageWikiLink ARL2L1.
- ADP_ribosylation_factor wikiPageWikiLink ARL3.
- ADP_ribosylation_factor wikiPageWikiLink ARL4A.
- ADP_ribosylation_factor wikiPageWikiLink ARL4C.
- ADP_ribosylation_factor wikiPageWikiLink ARL4D.
- ADP_ribosylation_factor wikiPageWikiLink ARL5.
- ADP_ribosylation_factor wikiPageWikiLink ARL5A.
- ADP_ribosylation_factor wikiPageWikiLink ARL5B.
- ADP_ribosylation_factor wikiPageWikiLink ARL6.
- ADP_ribosylation_factor wikiPageWikiLink ARL7.
- ADP_ribosylation_factor wikiPageWikiLink ARL8A.
- ADP_ribosylation_factor wikiPageWikiLink ARL8B.
- ADP_ribosylation_factor wikiPageWikiLink ARL9.
- ADP_ribosylation_factor wikiPageWikiLink Actin.
- ADP_ribosylation_factor wikiPageWikiLink Arf6.
- ADP_ribosylation_factor wikiPageWikiLink Atomic_mass_unit.
- ADP_ribosylation_factor wikiPageWikiLink Brefeldin_A.
- ADP_ribosylation_factor wikiPageWikiLink COPI.
- ADP_ribosylation_factor wikiPageWikiLink Category:Peripheral_membrane_proteins.
- ADP_ribosylation_factor wikiPageWikiLink Category:Protein_domains.
- ADP_ribosylation_factor wikiPageWikiLink Eukaryote.
- ADP_ribosylation_factor wikiPageWikiLink Eukaryotic.
- ADP_ribosylation_factor wikiPageWikiLink GTP-binding_protein.
- ADP_ribosylation_factor wikiPageWikiLink GTPase-activating_protein.
- ADP_ribosylation_factor wikiPageWikiLink GTPase_activating_protein.
- ADP_ribosylation_factor wikiPageWikiLink G_protein.
- ADP_ribosylation_factor wikiPageWikiLink Guanine_nucleotide_exchange_factor.
- ADP_ribosylation_factor wikiPageWikiLink Guanosine_diphosphate.
- ADP_ribosylation_factor wikiPageWikiLink Guanosine_triphosphate.
- ADP_ribosylation_factor wikiPageWikiLink Hydrolysis.
- ADP_ribosylation_factor wikiPageWikiLink Kilodalton.
- ADP_ribosylation_factor wikiPageWikiLink Lipid_bilayer.
- ADP_ribosylation_factor wikiPageWikiLink MGC57346.
- ADP_ribosylation_factor wikiPageWikiLink Myristoylation.
- ADP_ribosylation_factor wikiPageWikiLink N-terminus.
- ADP_ribosylation_factor wikiPageWikiLink Phosphodiesterase.
- ADP_ribosylation_factor wikiPageWikiLink Ras_superfamily.
- ADP_ribosylation_factor wikiPageWikiLink SAR1A.
- ADP_ribosylation_factor wikiPageWikiLink SAR1B.
- ADP_ribosylation_factor wikiPageWikiLink SAR1P3.
- ADP_ribosylation_factor wikiPageWikiLink SARA1.
- ADP_ribosylation_factor wikiPageWikiLink TRIM23.
- ADP_ribosylation_factor wikiPageWikiLink Vesicle_(biology).
- ADP_ribosylation_factor wikiPageWikiLink Vesicle_(biology_and_chemistry).
- ADP_ribosylation_factor wikiPageWikiLink File:ADP_ribosylation_factor_localization_in_the_Golgi_apparatus_of_a_living_macrophage.png.
- ADP_ribosylation_factor wikiPageWikiLinkText "ADP ribosylation factor".
- ADP_ribosylation_factor wikiPageWikiLinkText "ARF".
- ADP_ribosylation_factor wikiPageWikiLinkText "ARFs".
- ADP_ribosylation_factor wikiPageWikiLinkText "Arf".
- ADP_ribosylation_factor wikiPageWikiLinkText "Arf1".
- ADP_ribosylation_factor caption "Membrane-bound ADP ribosylation factor-like protein 2 , complex with phosphodiesterase delta Blue dots show hydrocarbon boundary of the lipid bilayer".
- ADP_ribosylation_factor cdd "cd00878".
- ADP_ribosylation_factor hasPhotoCollection ADP_ribosylation_factor.
- ADP_ribosylation_factor interpro "IPR006689".
- ADP_ribosylation_factor opmFamily "99".
- ADP_ribosylation_factor opmProtein "1".
- ADP_ribosylation_factor pfam "PF00025".
- ADP_ribosylation_factor prosite "PDOC01020".
- ADP_ribosylation_factor scop "1".
- ADP_ribosylation_factor smart "ARF".
- ADP_ribosylation_factor symbol "Arf".
- ADP_ribosylation_factor width "250".
- ADP_ribosylation_factor wikiPageUsesTemplate Template:About.
- ADP_ribosylation_factor wikiPageUsesTemplate Template:Cite_journal.
- ADP_ribosylation_factor wikiPageUsesTemplate Template:ELM.
- ADP_ribosylation_factor wikiPageUsesTemplate Template:GTPases.
- ADP_ribosylation_factor wikiPageUsesTemplate Template:Gene.
- ADP_ribosylation_factor wikiPageUsesTemplate Template:InterPro_content.
- ADP_ribosylation_factor wikiPageUsesTemplate Template:Intracellular_signaling_peptides_and_proteins.
- ADP_ribosylation_factor wikiPageUsesTemplate Template:Pfam_box.
- ADP_ribosylation_factor wikiPageUsesTemplate Template:Refbegin.
- ADP_ribosylation_factor wikiPageUsesTemplate Template:Refend.
- ADP_ribosylation_factor wikiPageUsesTemplate Template:Reflist.
- ADP_ribosylation_factor wikiPageUsesTemplate Template:Vesicular_transport_proteins.
- ADP_ribosylation_factor subject Category:Peripheral_membrane_proteins.
- ADP_ribosylation_factor subject Category:Protein_domains.
- ADP_ribosylation_factor hypernym Members.