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- ACAT1_mRNA abstract "Human acetyl-coA cholesterol acyltransferase (ACAT1) gene produces a chimeric mRNA through the interchromosomal processing of two discontinuous RNAs transcribed from chromosomes 1 and 7. This chimeric mRNA uses AUG as a translation initiation codon to produce the normal 50-kDa ACAT1 protein but used an alternative translation initiation codon, GGC, to produce the novel enzymatically active 56-kDa isoform.Mutagenesis and mass spectrometry identified the alternative initiation codon as the start codon for the novel 56-kDa protein and its location was mapped to a region located upstream of the AUG initiation codon. Three stem loop structures have been predicted to surround the GCC initiation codon and are known as SL1 to SL3. Mutations that disrupted these stem-loop structures showed that SL1 and SL2 as required for translation initiation from the GGC codon but SL3 has no effect on translation efficiency. Translation initiation from the GGC codon was shown to be is mediated by an internal ribosome entry site (IRES) which requires SL1 located upstream of the IRES and SL2 located downstream. This study also showed that SL3 influences the choice of downstream AUG translation initiation codons that will produce the normal 50-KDa human ACAT1 protein.".
- ACAT1_mRNA thumbnail ACAT_SS.png?width=300.
- ACAT1_mRNA wikiPageID "24208489".
- ACAT1_mRNA wikiPageLength "4344".
- ACAT1_mRNA wikiPageOutDegree "16".
- ACAT1_mRNA wikiPageRevisionID "678211693".
- ACAT1_mRNA wikiPageWikiLink ACAT1.
- ACAT1_mRNA wikiPageWikiLink Atomic_mass_unit.
- ACAT1_mRNA wikiPageWikiLink Biomolecular_structure.
- ACAT1_mRNA wikiPageWikiLink Category:RNA.
- ACAT1_mRNA wikiPageWikiLink Chromosome.
- ACAT1_mRNA wikiPageWikiLink Chromosomes.
- ACAT1_mRNA wikiPageWikiLink Enzyme.
- ACAT1_mRNA wikiPageWikiLink Fusion_protein.
- ACAT1_mRNA wikiPageWikiLink Internal_ribosome_entry_site.
- ACAT1_mRNA wikiPageWikiLink KDa.
- ACAT1_mRNA wikiPageWikiLink MRNA.
- ACAT1_mRNA wikiPageWikiLink Mass_spectrometry.
- ACAT1_mRNA wikiPageWikiLink Messenger_RNA.
- ACAT1_mRNA wikiPageWikiLink Mutagenesis.
- ACAT1_mRNA wikiPageWikiLink RNA.
- ACAT1_mRNA wikiPageWikiLink Secondary_structure.
- ACAT1_mRNA wikiPageWikiLink Start_codon.
- ACAT1_mRNA wikiPageWikiLink Stem-loop.
- ACAT1_mRNA wikiPageWikiLink Stem_loop.
- ACAT1_mRNA wikiPageWikiLink Translation_(biology).
- ACAT1_mRNA wikiPageWikiLink Translation_(genetics).
- ACAT1_mRNA wikiPageWikiLinkText "ACAT1 mRNA".
- ACAT1_mRNA caption "Conserved secondary structure of ACAT1 mRNA".
- ACAT1_mRNA go "6446".
- ACAT1_mRNA hasPhotoCollection ACAT1_mRNA.
- ACAT1_mRNA id "RF01495".
- ACAT1_mRNA name "ACAT1 mRNA".
- ACAT1_mRNA name "ACAT1".
- ACAT1_mRNA rfam "RF01495".
- ACAT1_mRNA so "5836".
- ACAT1_mRNA symbol "ACAT1".
- ACAT1_mRNA wikiPageUsesTemplate Template:Infobox_rfam.
- ACAT1_mRNA wikiPageUsesTemplate Template:Reflist.
- ACAT1_mRNA wikiPageUsesTemplate Template:Rfam.
- ACAT1_mRNA subject Category:RNA.
- ACAT1_mRNA type Article.
- ACAT1_mRNA type Article.
- ACAT1_mRNA comment "Human acetyl-coA cholesterol acyltransferase (ACAT1) gene produces a chimeric mRNA through the interchromosomal processing of two discontinuous RNAs transcribed from chromosomes 1 and 7.".
- ACAT1_mRNA label "ACAT1 mRNA".
- ACAT1_mRNA sameAs m.07kj4ww.
- ACAT1_mRNA sameAs Q4650509.
- ACAT1_mRNA sameAs Q4650509.
- ACAT1_mRNA wasDerivedFrom ACAT1_mRNA?oldid=678211693.
- ACAT1_mRNA depiction ACAT_SS.png.
- ACAT1_mRNA isPrimaryTopicOf ACAT1_mRNA.