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- AB_toxin abstract "The AB toxins are two-component protein complexes secreted by a number of pathogenic bacteria. They can be classified as Type III toxins because they interfere with internal cell function. They are named AB toxins due to their components: the "A" component is usually the "active" portion, and the "B" component is usually the "binding" portion. The "A" subunit possesses enzyme activity, and is transferred to the host cell following a conformational change in the membrane-bound transport "B" subunit.Among the toxins produced by certain Clostridium spp. are the binary exotoxins. These proteins consist of two independent polypeptides, which correspond to the A/B subunit moieties. The enzyme component (A) enters the cell through endosomes produced by the oligomeric binding/translocation protein (B), and prevents actin polymerisation through ADP-ribosylation of monomeric G-actin.Members of the "A" binary toxin family include C. perfringens iota toxin Ia, C. botulinum C2 toxin CI, and Clostridium difficile ADP-ribosyltransferase . Other homologous proteins have been found in Clostridium spiroforme.Members of the "B" binary toxin family include the Bacillus anthracis protective antigen (PA) protein, most likely due to a common evolutionary ancestor. B. anthracis, a large Gram-positive spore-forming rod, is the causative agent of anthrax. Its two virulence factors are the poly-D-glutamate polypeptide capsule, and the actual anthrax exotoxin. The toxin comprises three factors: the protective antigen (PA); the oedema factor (EF); and the lethal factor (LF). Each is a thermolabile protein of ~80kDa. PA forms the "B" part of the exotoxin and allows passage of the "A" moiety (consisting of EF and LF) into target cells. PA protein forms the central part of the complete anthrax toxin, and translocates the B moiety into host cells after assembling as a heptamer in the membrane.The Diphteria toxin also is an AB toxin. It inhibits protein synthesis in the host cell through phosphorylation of the eukaryotic elongation factor 2, which is an essential component for protein synthesis. The exotoxin A of Pseudomonas aeruginosa is another example of an AB toxin that targets the eukaryotic elongation factor 2.The AB5 toxins are usually considered a type of AB toxin, characterized by B pentamers. Less commonly, the term "AB toxin" is used to emphasize the monomeric character of the B component.".
- AB_toxin symbol "ADPrib_exo_Tox".
- AB_toxin symbol "Binary_toxB".
- AB_toxin thumbnail PDB_1giq_EBI.jpg?width=300.
- AB_toxin wikiPageID "20681039".
- AB_toxin wikiPageLength "7276".
- AB_toxin wikiPageOutDegree "35".
- AB_toxin wikiPageRevisionID "680333837".
- AB_toxin wikiPageWikiLink AB5_toxin.
- AB_toxin wikiPageWikiLink Actin.
- AB_toxin wikiPageWikiLink Antigen.
- AB_toxin wikiPageWikiLink Bacillus_anthracis.
- AB_toxin wikiPageWikiLink Bacteria.
- AB_toxin wikiPageWikiLink Biological_membrane.
- AB_toxin wikiPageWikiLink C._botulinum.
- AB_toxin wikiPageWikiLink C._perfringens.
- AB_toxin wikiPageWikiLink Category:Bacterial_toxins.
- AB_toxin wikiPageWikiLink Category:Protein_families.
- AB_toxin wikiPageWikiLink Cell_(biology).
- AB_toxin wikiPageWikiLink Cell_membrane.
- AB_toxin wikiPageWikiLink Clostridium_botulinum.
- AB_toxin wikiPageWikiLink Clostridium_difficile.
- AB_toxin wikiPageWikiLink Clostridium_difficile_colitis.
- AB_toxin wikiPageWikiLink Clostridium_perfringens.
- AB_toxin wikiPageWikiLink Conformational_change.
- AB_toxin wikiPageWikiLink Diphteria_toxin.
- AB_toxin wikiPageWikiLink Diphtheria_toxin.
- AB_toxin wikiPageWikiLink EEF2.
- AB_toxin wikiPageWikiLink Endosome.
- AB_toxin wikiPageWikiLink Enzyme.
- AB_toxin wikiPageWikiLink Evolution.
- AB_toxin wikiPageWikiLink Exotoxin.
- AB_toxin wikiPageWikiLink Gram-positive.
- AB_toxin wikiPageWikiLink Gram-positive_bacteria.
- AB_toxin wikiPageWikiLink Homology_(biology).
- AB_toxin wikiPageWikiLink Membrane-bound.
- AB_toxin wikiPageWikiLink Moiety_(chemistry).
- AB_toxin wikiPageWikiLink Pathogenicity.
- AB_toxin wikiPageWikiLink Peptide.
- AB_toxin wikiPageWikiLink Polypeptide.
- AB_toxin wikiPageWikiLink Protein.
- AB_toxin wikiPageWikiLink Pseudomonas_aeruginosa.
- AB_toxin wikiPageWikiLink Pseudomonas_exotoxin.
- AB_toxin wikiPageWikiLink Transport.
- AB_toxin wikiPageWikiLink Virulence_factor.
- AB_toxin wikiPageWikiLinkText "A-B toxin".
- AB_toxin wikiPageWikiLinkText "AB toxin".
- AB_toxin caption "crystal structure of the anthrax toxin protective antigen heptameric prepore".
- AB_toxin caption "crystal structure of the enzymatic component of iota-toxin from clostridium perfringens with nadh".
- AB_toxin hasPhotoCollection AB_toxin.
- AB_toxin interpro "IPR003540".
- AB_toxin interpro "IPR003896".
- AB_toxin name "ADPrib_exo_Tox".
- AB_toxin name "Binary_toxB".
- AB_toxin pfam "PF03495".
- AB_toxin pfam "PF03496".
- AB_toxin pfamClan "CL0084".
- AB_toxin scop "1".
- AB_toxin symbol "ADPrib_exo_Tox".
- AB_toxin symbol "Binary_toxB".
- AB_toxin tcdb "1".
- AB_toxin wikiPageUsesTemplate Template:Infobox_protein_family.
- AB_toxin wikiPageUsesTemplate Template:InterPro_content.
- AB_toxin wikiPageUsesTemplate Template:Reflist.
- AB_toxin wikiPageUsesTemplate Template:Toxins.
- AB_toxin subject Category:Bacterial_toxins.
- AB_toxin subject Category:Protein_families.
- AB_toxin hypernym Complexes.
- AB_toxin type AnatomicalStructure.
- AB_toxin type Biomolecule.
- AB_toxin type Protein.
- AB_toxin type Chemical.
- AB_toxin type Toxin.
- AB_toxin type Thing.
- AB_toxin type Q206229.
- AB_toxin type Q8054.
- AB_toxin comment "The AB toxins are two-component protein complexes secreted by a number of pathogenic bacteria. They can be classified as Type III toxins because they interfere with internal cell function. They are named AB toxins due to their components: the "A" component is usually the "active" portion, and the "B" component is usually the "binding" portion.".
- AB_toxin label "AB toxin".
- AB_toxin sameAs m.051zfpy.
- AB_toxin sameAs AB-toxin.
- AB_toxin sameAs Q4650462.
- AB_toxin sameAs Q4650462.
- AB_toxin wasDerivedFrom AB_toxin?oldid=680333837.
- AB_toxin depiction PDB_1giq_EBI.jpg.
- AB_toxin isPrimaryTopicOf AB_toxin.