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- A431_cells abstract "A431 cells are a model cell line (epidermoid carcinoma) used in biomedical research. More specifically, they are used in studies of the cell cycle and cancer-associated cell signalling pathways since they express abnormally high levels of the Epidermal growth factor receptor (EGFR). As such they are often used as a positive control for EGFR expression. They contain no functional p53, a potent tumor suppressor gene, and so are highly sensitive to mitogenic stimuli. A431 cells were established from an epidermoid carcinoma in the skin/epidermis of an 85- year-old female patient. Epidermal growth factor (EGF) stimulation of A431 cells induces rapid tyrosine phosphorylation of intracellular signalling proteins which control cellular processes such as growth, proliferation and apoptosis. At low (picomolar) concentrations EGF promotes cell growth of A431 cells whereas at higher (nanomolar) concentrations it inhibits growth by causing the cells to terminally differentiate. Treatment of A431 cells with bradykinin reduces basal and EGF-induced EGFR phosphorylation. Treatment with sertoli cell secreted growth factor (SCSGF) strongly induces cell proliferation. Stimulation of A431 cells with phorbol esters induces expression of interleukin 1-related protein IL1H.".
- A431_cells wikiPageID "19759966".
- A431_cells wikiPageLength "2951".
- A431_cells wikiPageOutDegree "26".
- A431_cells wikiPageRevisionID "662161465".
- A431_cells wikiPageWikiLink Apoptosis.
- A431_cells wikiPageWikiLink Biomedical_research.
- A431_cells wikiPageWikiLink Bradykinin.
- A431_cells wikiPageWikiLink Cancer.
- A431_cells wikiPageWikiLink Category:Cell_lines.
- A431_cells wikiPageWikiLink Cell_culture.
- A431_cells wikiPageWikiLink Cell_cycle.
- A431_cells wikiPageWikiLink Cell_line.
- A431_cells wikiPageWikiLink Cell_signaling.
- A431_cells wikiPageWikiLink Cell_signalling.
- A431_cells wikiPageWikiLink Cellular_differentiation.
- A431_cells wikiPageWikiLink Epidermal_growth_factor.
- A431_cells wikiPageWikiLink Epidermal_growth_factor_receptor.
- A431_cells wikiPageWikiLink Epidermoid_carcinoma.
- A431_cells wikiPageWikiLink Gene_expression.
- A431_cells wikiPageWikiLink IL1H.
- A431_cells wikiPageWikiLink Interleukin_1.
- A431_cells wikiPageWikiLink Interleukin_1_family.
- A431_cells wikiPageWikiLink Intracellular.
- A431_cells wikiPageWikiLink Medical_research.
- A431_cells wikiPageWikiLink Mitogen.
- A431_cells wikiPageWikiLink P53.
- A431_cells wikiPageWikiLink Phorbol.
- A431_cells wikiPageWikiLink Phorbol_esters.
- A431_cells wikiPageWikiLink Phosphorylation.
- A431_cells wikiPageWikiLink Protein.
- A431_cells wikiPageWikiLink Scientific_control.
- A431_cells wikiPageWikiLink Sertoli_cell.
- A431_cells wikiPageWikiLink Squamous-cell_carcinoma.
- A431_cells wikiPageWikiLink Tumor_suppressor_gene.
- A431_cells wikiPageWikiLink Tyrosine.
- A431_cells wikiPageWikiLinkText "A431 cells".
- A431_cells wikiPageWikiLinkText "A431".
- A431_cells hasPhotoCollection A431_cells.
- A431_cells wikiPageUsesTemplate Template:Reflist.
- A431_cells subject Category:Cell_lines.
- A431_cells hypernym Line.
- A431_cells type Line.
- A431_cells comment "A431 cells are a model cell line (epidermoid carcinoma) used in biomedical research. More specifically, they are used in studies of the cell cycle and cancer-associated cell signalling pathways since they express abnormally high levels of the Epidermal growth factor receptor (EGFR). As such they are often used as a positive control for EGFR expression. They contain no functional p53, a potent tumor suppressor gene, and so are highly sensitive to mitogenic stimuli.".
- A431_cells label "A431 cells".
- A431_cells sameAs A431_(Zelllinie).
- A431_cells sameAs m.04q2ktp.
- A431_cells sameAs Q4649310.
- A431_cells sameAs Q4649310.
- A431_cells wasDerivedFrom A431_cells?oldid=662161465.
- A431_cells isPrimaryTopicOf A431_cells.