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- 90Y-DOTA-biotin abstract "90Y-DOTA-biotin consists of a radioactive substance (yttrium-90) complexed by a chelating agent (DOTA), which in turn is attached to the vitamin biotin via a chemical linker. It is used experimentally in pretargeted radioimmunotherapy. Animal studies have been conducted as well as clinical studies in humans.In pretargeted radioimmunotherapy, two or three medications are applied in succession. At first, an antibody-drug conjugate is administered, which consists of a monoclonal antibody designed to target the tumour, and a chemical marker which in the case of DOTA-biotin therapy is one of the proteins avidin and streptavidin. After a time of typically one or two days to let the antibody accumulate in the tumour, a clearing agent may be given to eliminate residues of antibody that are still circulating in the bloodstream; this is especially done in humans. After a further waiting time, the radiotherapy (90Y-DOTA-biotin) is administered. Due to the high affinity of biotin to avidin and streptavidin, the radiotherapy accumulates where the antibody is, namely in the tumour, where it delivers its radioactivity.".
- 90Y-DOTA-biotin thumbnail 90Y-DOTA-biotin_skeletal.svg?width=300.
- 90Y-DOTA-biotin wikiPageID "1300740".
- 90Y-DOTA-biotin wikiPageLength "4392".
- 90Y-DOTA-biotin wikiPageOutDegree "12".
- 90Y-DOTA-biotin wikiPageRevisionID "678352622".
- 90Y-DOTA-biotin wikiPageWikiLink Antibody-drug_conjugate.
- 90Y-DOTA-biotin wikiPageWikiLink Avidin.
- 90Y-DOTA-biotin wikiPageWikiLink Biotin.
- 90Y-DOTA-biotin wikiPageWikiLink Category:Radiopharmaceuticals.
- 90Y-DOTA-biotin wikiPageWikiLink Chelating_agent.
- 90Y-DOTA-biotin wikiPageWikiLink Chelation.
- 90Y-DOTA-biotin wikiPageWikiLink DOTA_(chelator).
- 90Y-DOTA-biotin wikiPageWikiLink Monoclonal_antibody.
- 90Y-DOTA-biotin wikiPageWikiLink Radioactive.
- 90Y-DOTA-biotin wikiPageWikiLink Radioactive_decay.
- 90Y-DOTA-biotin wikiPageWikiLink Radioimmunotherapy.
- 90Y-DOTA-biotin wikiPageWikiLink Streptavidin.
- 90Y-DOTA-biotin wikiPageWikiLink Yttrium-90.
- 90Y-DOTA-biotin wikiPageWikiLink File:90Y-DOTA-biotin_skeletal.svg.
- 90Y-DOTA-biotin wikiPageWikiLinkText "90Y-DOTA-biotin".
- 90Y-DOTA-biotin hasPhotoCollection 90Y-DOTA-biotin.
- 90Y-DOTA-biotin wikiPageUsesTemplate Template:Antineoplastic-drug-stub.
- 90Y-DOTA-biotin wikiPageUsesTemplate Template:Reflist.
- 90Y-DOTA-biotin subject Category:Radiopharmaceuticals.
- 90Y-DOTA-biotin type Article.
- 90Y-DOTA-biotin type Biomolecule.
- 90Y-DOTA-biotin type Drug.
- 90Y-DOTA-biotin type Article.
- 90Y-DOTA-biotin type Biomolecule.
- 90Y-DOTA-biotin type Drug.
- 90Y-DOTA-biotin type Product.
- 90Y-DOTA-biotin comment "90Y-DOTA-biotin consists of a radioactive substance (yttrium-90) complexed by a chelating agent (DOTA), which in turn is attached to the vitamin biotin via a chemical linker. It is used experimentally in pretargeted radioimmunotherapy. Animal studies have been conducted as well as clinical studies in humans.In pretargeted radioimmunotherapy, two or three medications are applied in succession.".
- 90Y-DOTA-biotin label "90Y-DOTA-biotin".
- 90Y-DOTA-biotin sameAs m.0119qs45.
- 90Y-DOTA-biotin sameAs Q4645623.
- 90Y-DOTA-biotin sameAs Q4645623.
- 90Y-DOTA-biotin wasDerivedFrom 90Y-DOTA-biotin?oldid=678352622.
- 90Y-DOTA-biotin depiction 90Y-DOTA-biotin_skeletal.svg.
- 90Y-DOTA-biotin isPrimaryTopicOf 90Y-DOTA-biotin.