Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/7,8-Dihydroxyflavone> ?p ?o }
- 7,8-Dihydroxyflavone abstract "7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF), and is both orally-bioavailable and able to penetrate the blood-brain-barrier, though with a relatively short half-life (~9 min with 1 mg/kg oral administration in rats).7,8-DHF has demonstrated remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders, including depression, Alzheimer's disease, cognitive deficits in schizophrenia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, cerebral ischemia, fragile X syndrome, and Rett syndrome. 7,8-DHF also shows efficacy in animal models of age-associated cognitive impairment and enhances memory consolidation and emotional learning in healthy rodents. In addition, 7,8-DHF possesses powerful antioxidant activity independent of its actions on the TrkB receptor, and protects against glutamate-induced excitotoxicity, 6-hydroxydopamine-induced dopaminergic neurotoxicity, and oxidative stress-induced genotoxicity. It was also found to block methamphetamine-induced dopaminergic neurotoxicity, an effect which, in contrast to the preceding, was found to be TrkB-dependent.7,8-DHF has been found to act as a weak aromatase inhibitor in vitro (Ki = 10 μM), though there is evidence to suggest that this might not be the case in vivo. In addition, it has been found to inhibit aldehyde dehydrogenase and estrogen sulfotransferase in vitro (Ki = 35 μM and 1–3 μM, respectively), though similarly to the case of aromatase, these activities have not been confirmed in vivo. Unlike many other flavonoids, 7,8-DHF does not show any inhibitory activity on 17β-hydroxysteroid dehydrogenase. 7,8-DHF has also been observed to possess in vitro antiestrogenic effects at very high concentrations (Ki = 50 μM).".
- 7,8-Dihydroxyflavone atcPrefix "None".
- 7,8-Dihydroxyflavone casNumber "38183-03-8".
- 7,8-Dihydroxyflavone iupacName "7,8-Dihydroxy-2-phenyl-4H-chromen-4-one".
- 7,8-Dihydroxyflavone pubchem "1880".
- 7,8-Dihydroxyflavone thumbnail 7,8-dihydroxyflavone.svg?width=300.
- 7,8-Dihydroxyflavone wikiPageID "45178236".
- 7,8-Dihydroxyflavone wikiPageLength "18626".
- 7,8-Dihydroxyflavone wikiPageOutDegree "57".
- 7,8-Dihydroxyflavone wikiPageRevisionID "673035745".
- 7,8-Dihydroxyflavone wikiPageWikiLink 17Beta_Hydroxysteroid_dehydrogenase.
- 7,8-Dihydroxyflavone wikiPageWikiLink 17β-hydroxysteroid_dehydrogenase.
- 7,8-Dihydroxyflavone wikiPageWikiLink 6-hydroxydopamine.
- 7,8-Dihydroxyflavone wikiPageWikiLink Agonist.
- 7,8-Dihydroxyflavone wikiPageWikiLink Aldehyde_dehydrogenase.
- 7,8-Dihydroxyflavone wikiPageWikiLink Alzheimers_disease.
- 7,8-Dihydroxyflavone wikiPageWikiLink Amitriptyline.
- 7,8-Dihydroxyflavone wikiPageWikiLink Amyotrophic_lateral_sclerosis.
- 7,8-Dihydroxyflavone wikiPageWikiLink Animal_model.
- 7,8-Dihydroxyflavone wikiPageWikiLink Antiestrogen.
- 7,8-Dihydroxyflavone wikiPageWikiLink Antioxidant.
- 7,8-Dihydroxyflavone wikiPageWikiLink Aromatase_inhibitor.
- 7,8-Dihydroxyflavone wikiPageWikiLink Bioavailability.
- 7,8-Dihydroxyflavone wikiPageWikiLink Blood-brain-barrier.
- 7,8-Dihydroxyflavone wikiPageWikiLink Blood–brain_barrier.
- 7,8-Dihydroxyflavone wikiPageWikiLink Brain-derived_neurotrophic_factor.
- 7,8-Dihydroxyflavone wikiPageWikiLink Brain_ischemia.
- 7,8-Dihydroxyflavone wikiPageWikiLink Category:Antidepressants.
- 7,8-Dihydroxyflavone wikiPageWikiLink Category:Antioxidants.
- 7,8-Dihydroxyflavone wikiPageWikiLink Category:Flavones.
- 7,8-Dihydroxyflavone wikiPageWikiLink Category:Neuroprotective_agents.
- 7,8-Dihydroxyflavone wikiPageWikiLink Category:Nootropics.
- 7,8-Dihydroxyflavone wikiPageWikiLink Category:Phytoestrogens.
- 7,8-Dihydroxyflavone wikiPageWikiLink Category:TrkB_receptor_agonists.
- 7,8-Dihydroxyflavone wikiPageWikiLink Central_nervous_system.
- 7,8-Dihydroxyflavone wikiPageWikiLink Cerebral_ischemia.
- 7,8-Dihydroxyflavone wikiPageWikiLink Cognitive_deficit.
- 7,8-Dihydroxyflavone wikiPageWikiLink Cognitive_impairment.
- 7,8-Dihydroxyflavone wikiPageWikiLink Depression_(mood).
- 7,8-Dihydroxyflavone wikiPageWikiLink Diosmetin.
- 7,8-Dihydroxyflavone wikiPageWikiLink Dopaminergic.
- 7,8-Dihydroxyflavone wikiPageWikiLink Emotion_and_memory.
- 7,8-Dihydroxyflavone wikiPageWikiLink Emotional_learning.
- 7,8-Dihydroxyflavone wikiPageWikiLink Estrogen_sulfotransferase.
- 7,8-Dihydroxyflavone wikiPageWikiLink Excitotoxicity.
- 7,8-Dihydroxyflavone wikiPageWikiLink Flavone.
- 7,8-Dihydroxyflavone wikiPageWikiLink Flavones.
- 7,8-Dihydroxyflavone wikiPageWikiLink Flavonoid.
- 7,8-Dihydroxyflavone wikiPageWikiLink Fragile_X_syndrome.
- 7,8-Dihydroxyflavone wikiPageWikiLink Genotoxicity.
- 7,8-Dihydroxyflavone wikiPageWikiLink Glutamate.
- 7,8-Dihydroxyflavone wikiPageWikiLink Glutamic_acid.
- 7,8-Dihydroxyflavone wikiPageWikiLink Godmania_aesculifolia.
- 7,8-Dihydroxyflavone wikiPageWikiLink HIOC.
- 7,8-Dihydroxyflavone wikiPageWikiLink Half-life.
- 7,8-Dihydroxyflavone wikiPageWikiLink Huntingtons_disease.
- 7,8-Dihydroxyflavone wikiPageWikiLink Memory_consolidation.
- 7,8-Dihydroxyflavone wikiPageWikiLink Methamphetamine.
- 7,8-Dihydroxyflavone wikiPageWikiLink Model_organism.
- 7,8-Dihydroxyflavone wikiPageWikiLink Mouth.
- 7,8-Dihydroxyflavone wikiPageWikiLink N-Acetylserotonin.
- 7,8-Dihydroxyflavone wikiPageWikiLink Natural_product.
- 7,8-Dihydroxyflavone wikiPageWikiLink Neurotoxicity.
- 7,8-Dihydroxyflavone wikiPageWikiLink Oxidative_stress.
- 7,8-Dihydroxyflavone wikiPageWikiLink Oxidopamine.
- 7,8-Dihydroxyflavone wikiPageWikiLink Parkinsons_disease.
- 7,8-Dihydroxyflavone wikiPageWikiLink Receptor_(biochemistry).
- 7,8-Dihydroxyflavone wikiPageWikiLink Rett_syndrome.
- 7,8-Dihydroxyflavone wikiPageWikiLink SULT1E1.
- 7,8-Dihydroxyflavone wikiPageWikiLink Schizophrenia.
- 7,8-Dihydroxyflavone wikiPageWikiLink Small-molecule.
- 7,8-Dihydroxyflavone wikiPageWikiLink Small_molecule.
- 7,8-Dihydroxyflavone wikiPageWikiLink Traumatic_brain_injury.
- 7,8-Dihydroxyflavone wikiPageWikiLink Tridax_procumbens.
- 7,8-Dihydroxyflavone wikiPageWikiLink TrkB_receptor.
- 7,8-Dihydroxyflavone wikiPageWikiLink Tropomyosin_receptor_kinase_B.
- 7,8-Dihydroxyflavone wikiPageWikiLinkText "7,8-Dihydroxyflavone".
- 7,8-Dihydroxyflavone atcPrefix "None".
- 7,8-Dihydroxyflavone casNumber "38183".
- 7,8-Dihydroxyflavone chemicalFormula "C15H10O4".
- 7,8-Dihydroxyflavone chemspiderid "1809".
- 7,8-Dihydroxyflavone hasPhotoCollection 7,8-Dihydroxyflavone.
- 7,8-Dihydroxyflavone inchi "1".
- 7,8-Dihydroxyflavone inchikey "COCYGNDCWFKTMF-UHFFFAOYAA".
- 7,8-Dihydroxyflavone iupacName "78".
- 7,8-Dihydroxyflavone molecularWeight "254.238".
- 7,8-Dihydroxyflavone pubchem "1880".
- 7,8-Dihydroxyflavone smiles "c1cccc2ccc3cccO".
- 7,8-Dihydroxyflavone stdinchi "1".
- 7,8-Dihydroxyflavone stdinchikey "COCYGNDCWFKTMF-UHFFFAOYSA-N".
- 7,8-Dihydroxyflavone wikiPageUsesTemplate Template:Antioxidants.
- 7,8-Dihydroxyflavone wikiPageUsesTemplate Template:Drugbox.
- 7,8-Dihydroxyflavone wikiPageUsesTemplate Template:Estrogenics.
- 7,8-Dihydroxyflavone wikiPageUsesTemplate Template:Flavones.
- 7,8-Dihydroxyflavone wikiPageUsesTemplate Template:Neurotrophinergics.
- 7,8-Dihydroxyflavone wikiPageUsesTemplate Template:Phytoestrogens.
- 7,8-Dihydroxyflavone wikiPageUsesTemplate Template:Reflist.
- 7,8-Dihydroxyflavone subject Category:Antidepressants.
- 7,8-Dihydroxyflavone subject Category:Antioxidants.
- 7,8-Dihydroxyflavone subject Category:Flavones.