Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/5-Chloro-αMT> ?p ?o }
- 5-Chloro-αMT abstract "5-Chloro-α-methyltryptamine (5-Chloro-αMT), also known as PAL-542, is a tryptamine derivative related to α-methyltryptamine (αMT) and one of only a few known specific serotonin-dopamine releasing agents (SDRAs). It has been investigated in animals as a potential treatment for cocaine dependence. The EC50 values of 5-chloro-αMT in evoking the in vitro release of serotonin (5-HT), dopamine (DA), and norepinephrine (NE) in rat synaptosomes were reported as 16 nM, 54 nM, and 3434 nM, with an NE/DA ratio of 63.6 and a DA/5-HT ratio of 3.38, indicating that it is a highly specific and well-balanced SDRA. However, 5-chloro-αMT has also been found to act as a potent full agonist of the 5-HT2A receptor, with an EC50 value of 6.27 nM and an efficacy of 105%, and almost assuredly acts as a potent agonist of other serotonin receptors as well.5-Chloro-αMT was found to not reliably produce intracranial self-administration in rats or substitute for cocaine in rats or monkeys. It was found through study of 5-chloro-αMT in rhesus monkeys that norepinephrine release has minimal influence on the abuse potential of monoamine releasing agents and that loss of norepinephrine release activity does not affect efficacy in reducing cocaine self-administration in SDRAs relative to serotonin-norepinephrine-dopamine releasing agents (SNDRAs) such as naphthylisopropylamine (PAL-287). However, SDRAs like PAL-542 would, in theory, be expected to produce fewer side effects (including sympathomimetic/cardiovascular effects, insomnia, hyperthermia, and anxiety) relative to SNDRAs, and thus would likely be comparatively more favorable in the treatment of cocaine dependence and other conditions.A related agent, 5-fluoro-α-methyltryptamine (5-fluoro-αMT), also known as PAL-544, is a potent MAO-A inhibitor in addition to SNDRA and 5-HT2A receptor agonist. Due to their close structural similarity, 5-chloro-αMT might also possess activity as an MAO-A inhibitor, a property which, in combination with its activity as monoamine releasing agent, could potentially render it dangerous in an analogous manner to the phenethylamine derivative para-methoxyamphetamine (PMA). In addition, α-ethyltryptamine (αET), an SNDRA and close structural analog of αMT and 5-chloro-αMT, like many other releasing agents of both 5-HT and DA such as MDMA, has been found to produce long-lasting serotonergic neurotoxicity in rats, and the same could also prove true for 5-chloro-αMT and other monoamine-releasing tryptamines.As a 5-HT2A receptor agonist, 5-chloro-αMT likely possesses the capacity for psychedelic effects. Indeed, its close analog 5-fluoro-αMT produces a strong head-twitch response in rats, a property which is highly correlated with psychedelic effects in humans.".
- 5-Chloro-αMT atcPrefix "None".
- 5-Chloro-αMT casNumber "712-07-2".
- 5-Chloro-αMT iupacName "1-(5-chloro-1H-indol-3-yl)propan-2-amine".
- 5-Chloro-αMT pubchem "12833".
- 5-Chloro-αMT thumbnail 5-Chloro-3-(2-aminopropyl)indole.svg?width=300.
- 5-Chloro-αMT wikiPageID "44678225".
- 5-Chloro-αMT wikiPageLength "8894".
- 5-Chloro-αMT wikiPageOutDegree "63".
- 5-Chloro-αMT wikiPageRevisionID "670812603".
- 5-Chloro-αMT wikiPageWikiLink 3,4-methylenedioxy-N-methylamphetamine.
- 5-Chloro-αMT wikiPageWikiLink 4-HO-αMT.
- 5-Chloro-αMT wikiPageWikiLink 4-Hydroxy-αMT.
- 5-Chloro-αMT wikiPageWikiLink 4-Me-αMT.
- 5-Chloro-αMT wikiPageWikiLink 4-Methyl-α-ethyltryptamine.
- 5-Chloro-αMT wikiPageWikiLink 4-Methyl-αET.
- 5-Chloro-αMT wikiPageWikiLink 4-Methyl-αMT.
- 5-Chloro-αMT wikiPageWikiLink 5-(2-Aminopropyl)indole.
- 5-Chloro-αMT wikiPageWikiLink 5-Fluoro-AMT.
- 5-Chloro-αMT wikiPageWikiLink 5-HT2A_receptor.
- 5-Chloro-αMT wikiPageWikiLink 5-HT_receptor.
- 5-Chloro-αMT wikiPageWikiLink 5-IT.
- 5-Chloro-αMT wikiPageWikiLink 5-MeO-AET.
- 5-Chloro-αMT wikiPageWikiLink 5-MeO-aMT.
- 5-Chloro-αMT wikiPageWikiLink 5-MeO-αET.
- 5-Chloro-αMT wikiPageWikiLink 5-MeO-αMT.
- 5-Chloro-αMT wikiPageWikiLink 5-fluoro-α-methyltryptamine.
- 5-Chloro-αMT wikiPageWikiLink 6-Fluoro-AMT.
- 5-Chloro-αMT wikiPageWikiLink 6-Fluoro-αMT.
- 5-Chloro-αMT wikiPageWikiLink 7-Methyl-α-ethyltryptamine.
- 5-Chloro-αMT wikiPageWikiLink 7-Methyl-αET.
- 5-Chloro-αMT wikiPageWikiLink Abuse_potential.
- 5-Chloro-αMT wikiPageWikiLink Agonist.
- 5-Chloro-αMT wikiPageWikiLink Alpha-Ethyltryptamine.
- 5-Chloro-αMT wikiPageWikiLink Alpha-Methyltryptamine.
- 5-Chloro-αMT wikiPageWikiLink Alpha-N,N-Trimethyltryptamine.
- 5-Chloro-αMT wikiPageWikiLink Anxiety.
- 5-Chloro-αMT wikiPageWikiLink Cardiovascular.
- 5-Chloro-αMT wikiPageWikiLink Category:Chloroarenes.
- 5-Chloro-αMT wikiPageWikiLink Category:Entactogens_and_empathogens.
- 5-Chloro-αMT wikiPageWikiLink Category:Psychedelic_tryptamines.
- 5-Chloro-αMT wikiPageWikiLink Category:Serotonin-dopamine_releasing_agents.
- 5-Chloro-αMT wikiPageWikiLink Category:Serotonin_receptor_agonists.
- 5-Chloro-αMT wikiPageWikiLink Category:Stimulants.
- 5-Chloro-αMT wikiPageWikiLink Chemical_derivative.
- 5-Chloro-αMT wikiPageWikiLink Chemical_structure.
- 5-Chloro-αMT wikiPageWikiLink Circulatory_system.
- 5-Chloro-αMT wikiPageWikiLink Cocaine.
- 5-Chloro-αMT wikiPageWikiLink Cocaine_dependence.
- 5-Chloro-αMT wikiPageWikiLink Cranial_cavity.
- 5-Chloro-αMT wikiPageWikiLink Derivative_(chemistry).
- 5-Chloro-αMT wikiPageWikiLink Dopamine.
- 5-Chloro-αMT wikiPageWikiLink EC50.
- 5-Chloro-αMT wikiPageWikiLink Efficacy.
- 5-Chloro-αMT wikiPageWikiLink Exocytosis.
- 5-Chloro-αMT wikiPageWikiLink Federal_Analog_Act.
- 5-Chloro-αMT wikiPageWikiLink Federal_Analogue_Act.
- 5-Chloro-αMT wikiPageWikiLink Full_agonist.
- 5-Chloro-αMT wikiPageWikiLink Head-twitch_response.
- 5-Chloro-αMT wikiPageWikiLink Hyperthermia.
- 5-Chloro-αMT wikiPageWikiLink In_vitro.
- 5-Chloro-αMT wikiPageWikiLink Insomnia.
- 5-Chloro-αMT wikiPageWikiLink Intracranial.
- 5-Chloro-αMT wikiPageWikiLink Intrinsic_activity.
- 5-Chloro-αMT wikiPageWikiLink MAO-A_inhibitor.
- 5-Chloro-αMT wikiPageWikiLink MDMA.
- 5-Chloro-αMT wikiPageWikiLink Monoamine_oxidase_inhibitor.
- 5-Chloro-αMT wikiPageWikiLink Monoamine_releasing_agent.
- 5-Chloro-αMT wikiPageWikiLink Naphthylaminopropane.
- 5-Chloro-αMT wikiPageWikiLink Naphthylisopropylamine.
- 5-Chloro-αMT wikiPageWikiLink Neurotoxicity.
- 5-Chloro-αMT wikiPageWikiLink Neurotransmitter_release.
- 5-Chloro-αMT wikiPageWikiLink Norepinephrine.
- 5-Chloro-αMT wikiPageWikiLink Para-Methoxyamphetamine.
- 5-Chloro-αMT wikiPageWikiLink Psychedelic_drug.
- 5-Chloro-αMT wikiPageWikiLink Releasing_agent.
- 5-Chloro-αMT wikiPageWikiLink Rhesus_macaque.
- 5-Chloro-αMT wikiPageWikiLink Rhesus_monkey.
- 5-Chloro-αMT wikiPageWikiLink Self-administration.
- 5-Chloro-αMT wikiPageWikiLink Serotonergic.
- 5-Chloro-αMT wikiPageWikiLink Serotonin.
- 5-Chloro-αMT wikiPageWikiLink Serotonin-dopamine_releasing_agent.
- 5-Chloro-αMT wikiPageWikiLink Serotonin-norepinephrine-dopamine_releasing_agent.
- 5-Chloro-αMT wikiPageWikiLink Serotonin_receptor.
- 5-Chloro-αMT wikiPageWikiLink Side_effect.
- 5-Chloro-αMT wikiPageWikiLink Structural_analog.
- 5-Chloro-αMT wikiPageWikiLink Substance_abuse.
- 5-Chloro-αMT wikiPageWikiLink Substituted_phenethylamine.
- 5-Chloro-αMT wikiPageWikiLink Sympathomimetic.
- 5-Chloro-αMT wikiPageWikiLink Sympathomimetic_drug.
- 5-Chloro-αMT wikiPageWikiLink Synaptosome.
- 5-Chloro-αMT wikiPageWikiLink Tryptamine.
- 5-Chloro-αMT wikiPageWikiLink United_States.
- 5-Chloro-αMT wikiPageWikiLink Α-ethyltryptamine.
- 5-Chloro-αMT wikiPageWikiLink Α-methyltryptamine.
- 5-Chloro-αMT wikiPageWikiLinkText "5-Chloro-αMT".
- 5-Chloro-αMT atcPrefix "None".
- 5-Chloro-αMT c "11".
- 5-Chloro-αMT casNumber "0712-07-02".
- 5-Chloro-αMT chemspiderid "12303".