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- 5-Bromouracil abstract "5-Bromouracil (or 5-bromo-2,4(1H,3H)-pyrimidinedione or 5-BrU or 5-BU) is a brominated derivative of uracil that acts as an antimetabolite or base analog, substituting for thymine in DNA, and can induce DNA mutation in the same way as 2-aminopurine. It is used mainly as an experimental mutagen, but its deoxyriboside derivative (5-bromo-2-deoxy-uridine) is used to treat neoplasms.5-BrU exists in three tautomeric forms that have different base pairing properties. The keto form (shown in the infobox) is complementary to adenine, so it can be incorporated into DNA by aligning opposite adenine residues during DNA replication (see below left). Alternatively, the enol (below right) and ion forms are complementary to guanine. This means that 5-BrU can be present in DNA either opposite adenine or guanine.The three forms frequently interchange so base-pairing properties can become altered at any time. The result of this is that during a subsequent round of replication a different base is aligned opposite the 5-BrU residue. Further rounds of replication 'fix' the change by incorporating a normal nitrogen base into the complementary strand.Thus 5-BrU induces a point mutation via base substitution. This base pair will change from an A-T to a G-C or from a G-C to an A-T after a number of replication cycles, depending on whether 5-BrU is within the DNA molecule or is an incoming base when it is enolized or ionized.".
- 5-Bromouracil iupacName "5-Bromo-1H-pyrimidine-2,4-dione".
- 5-Bromouracil thumbnail 5-Bromouracil_structure.png?width=300.
- 5-Bromouracil wikiPageID "487352".
- 5-Bromouracil wikiPageLength "3383".
- 5-Bromouracil wikiPageOutDegree "21".
- 5-Bromouracil wikiPageRevisionID "670368175".
- 5-Bromouracil wikiPageWikiLink 2-Aminopurine.
- 5-Bromouracil wikiPageWikiLink 2-aminopurine.
- 5-Bromouracil wikiPageWikiLink 5-bromo-2-deoxy-uridine.
- 5-Bromouracil wikiPageWikiLink Adenine.
- 5-Bromouracil wikiPageWikiLink Antimetabolite.
- 5-Bromouracil wikiPageWikiLink Base_analog.
- 5-Bromouracil wikiPageWikiLink Bromodeoxyuridine.
- 5-Bromouracil wikiPageWikiLink Category:Biomolecules.
- 5-Bromouracil wikiPageWikiLink Category:Nucleobases.
- 5-Bromouracil wikiPageWikiLink Category:Organobromides.
- 5-Bromouracil wikiPageWikiLink Category:Pyrimidinediones.
- 5-Bromouracil wikiPageWikiLink DNA.
- 5-Bromouracil wikiPageWikiLink Enol.
- 5-Bromouracil wikiPageWikiLink Guanine.
- 5-Bromouracil wikiPageWikiLink Ketone.
- 5-Bromouracil wikiPageWikiLink Mutagen.
- 5-Bromouracil wikiPageWikiLink Mutation.
- 5-Bromouracil wikiPageWikiLink Neoplasm.
- 5-Bromouracil wikiPageWikiLink Point_mutation.
- 5-Bromouracil wikiPageWikiLink Tautomer.
- 5-Bromouracil wikiPageWikiLink Thymine.
- 5-Bromouracil wikiPageWikiLink Uracil.
- 5-Bromouracil wikiPageWikiLink File:5-Bromouracil_bp.svg.
- 5-Bromouracil wikiPageWikiLinkText "5-Bromouracil".
- 5-Bromouracil hasPhotoCollection 5-Bromouracil.
- 5-Bromouracil imagefile "5".
- 5-Bromouracil imagesize "150".
- 5-Bromouracil iupacname "5".
- 5-Bromouracil othernames "5".
- 5-Bromouracil verifiedrevid "477224151".
- 5-Bromouracil wikiPageUsesTemplate Template:Biochem-stub.
- 5-Bromouracil wikiPageUsesTemplate Template:Chembox.
- 5-Bromouracil subject Category:Biomolecules.
- 5-Bromouracil subject Category:Nucleobases.
- 5-Bromouracil subject Category:Organobromides.
- 5-Bromouracil subject Category:Pyrimidinediones.
- 5-Bromouracil hypernym Derivative.
- 5-Bromouracil type Biomolecule.
- 5-Bromouracil type ChemicalCompound.
- 5-Bromouracil type ChemicalSubstance.
- 5-Bromouracil type Biomolecule.
- 5-Bromouracil type Lactam.
- 5-Bromouracil type Organohalide.
- 5-Bromouracil type Product.
- 5-Bromouracil type Organohalide.
- 5-Bromouracil type ChemicalObject.
- 5-Bromouracil type Thing.
- 5-Bromouracil type Q11173.
- 5-Bromouracil comment "5-Bromouracil (or 5-bromo-2,4(1H,3H)-pyrimidinedione or 5-BrU or 5-BU) is a brominated derivative of uracil that acts as an antimetabolite or base analog, substituting for thymine in DNA, and can induce DNA mutation in the same way as 2-aminopurine. It is used mainly as an experimental mutagen, but its deoxyriboside derivative (5-bromo-2-deoxy-uridine) is used to treat neoplasms.5-BrU exists in three tautomeric forms that have different base pairing properties.".
- 5-Bromouracil label "5-Bromouracil".
- 5-Bromouracil sameAs 5-Bromuracil.
- 5-Bromouracil sameAs ۵-بروموراسیل.
- 5-Bromouracil sameAs 5-Bromouracile.
- 5-Bromouracil sameAs m.02gddj.
- 5-Bromouracil sameAs 5-Bromouracil.
- 5-Bromouracil sameAs 5-Bromouracil.
- 5-Bromouracil sameAs Q238477.
- 5-Bromouracil sameAs Q238477.
- 5-Bromouracil wasDerivedFrom 5-Bromouracil?oldid=670368175.
- 5-Bromouracil depiction 5-Bromouracil_structure.png.
- 5-Bromouracil isPrimaryTopicOf 5-Bromouracil.