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- 4-O-Methylhonokiol abstract "4-O-Methylhonokiol is a neolignan, a type of phenolic compounds. It is found in the bark of Magnolia grandiflora and in M. virginiana flowers.4-O-Methylhonokiol is a potent CB2 receptor ligand (Ki = 50 nM), showing a unique inverse agonism and partial agonism via different pathways (cAMP and Ca2+) and potently inhibits osteoclastogenesis. 4-O-Methylhonokiol further attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway. The different neuroprotective and anti-Alzheimer Disease effects reported in rodent models may be mediated via CB2 receptors, providing that the compound should be orally bioavailable to the brain. It was shown that 4-O-methylhonokiol activates CB2 receptors and also inhibits the oxygenation of the major endocannabinoid 2-AG via COX-2 in a substrate-selective manner, thus leading to potential synergistic effects at CB receptors. The same study also provided data that this natural product can readily pass the blood–brain barrier, using LC-MS/MS.".
- 4-O-Methylhonokiol iupacName "2-(4-Methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol".
- 4-O-Methylhonokiol thumbnail Methylhonokiol.svg?width=300.
- 4-O-Methylhonokiol wikiPageID "37241492".
- 4-O-Methylhonokiol wikiPageLength "5000".
- 4-O-Methylhonokiol wikiPageOutDegree "12".
- 4-O-Methylhonokiol wikiPageRevisionID "679453159".
- 4-O-Methylhonokiol wikiPageWikiLink Astrocyte.
- 4-O-Methylhonokiol wikiPageWikiLink Bark_isolate.
- 4-O-Methylhonokiol wikiPageWikiLink CB2_receptor.
- 4-O-Methylhonokiol wikiPageWikiLink Cannabinoid_receptor_type_2.
- 4-O-Methylhonokiol wikiPageWikiLink Category:Cannabinoids.
- 4-O-Methylhonokiol wikiPageWikiLink Category:GABAA_receptor_positive_allosteric_modulators.
- 4-O-Methylhonokiol wikiPageWikiLink Category:Lignans.
- 4-O-Methylhonokiol wikiPageWikiLink Inverse_agonist.
- 4-O-Methylhonokiol wikiPageWikiLink Lignan.
- 4-O-Methylhonokiol wikiPageWikiLink Magnolia_grandiflora.
- 4-O-Methylhonokiol wikiPageWikiLink Magnolia_virginiana.
- 4-O-Methylhonokiol wikiPageWikiLink Neolignan.
- 4-O-Methylhonokiol wikiPageWikiLink PSEN2.
- 4-O-Methylhonokiol wikiPageWikiLink Partial_agonist.
- 4-O-Methylhonokiol wikiPageWikiLink Presenilin_2.
- 4-O-Methylhonokiol wikiPageWikiLinkText "4-O-Methylhonokiol".
- 4-O-Methylhonokiol hasPhotoCollection 4-O-Methylhonokiol.
- 4-O-Methylhonokiol imagefile "Methylhonokiol.svg".
- 4-O-Methylhonokiol iupacname "2".
- 4-O-Methylhonokiol name "4".
- 4-O-Methylhonokiol othernames "35".
- 4-O-Methylhonokiol wikiPageUsesTemplate Template:Cannabinoidergics.
- 4-O-Methylhonokiol wikiPageUsesTemplate Template:Chembox.
- 4-O-Methylhonokiol wikiPageUsesTemplate Template:GABAAR_PAMs.
- 4-O-Methylhonokiol wikiPageUsesTemplate Template:Lignans.
- 4-O-Methylhonokiol wikiPageUsesTemplate Template:Natural_phenol-stub.
- 4-O-Methylhonokiol wikiPageUsesTemplate Template:Reflist.
- 4-O-Methylhonokiol subject Category:Cannabinoids.
- 4-O-Methylhonokiol subject Category:GABAA_receptor_positive_allosteric_modulators.
- 4-O-Methylhonokiol subject Category:Lignans.
- 4-O-Methylhonokiol hypernym Neolignan.
- 4-O-Methylhonokiol type Article.
- 4-O-Methylhonokiol type ChemicalCompound.
- 4-O-Methylhonokiol type ChemicalSubstance.
- 4-O-Methylhonokiol type Article.
- 4-O-Methylhonokiol type Lignan.
- 4-O-Methylhonokiol type Phenylpropanoid.
- 4-O-Methylhonokiol type ChemicalObject.
- 4-O-Methylhonokiol type Thing.
- 4-O-Methylhonokiol type Q11173.
- 4-O-Methylhonokiol comment "4-O-Methylhonokiol is a neolignan, a type of phenolic compounds. It is found in the bark of Magnolia grandiflora and in M. virginiana flowers.4-O-Methylhonokiol is a potent CB2 receptor ligand (Ki = 50 nM), showing a unique inverse agonism and partial agonism via different pathways (cAMP and Ca2+) and potently inhibits osteoclastogenesis.".
- 4-O-Methylhonokiol label "4-O-Methylhonokiol".
- 4-O-Methylhonokiol sameAs m.0n50b71.
- 4-O-Methylhonokiol sameAs 4-O-Metilhonokiol.
- 4-O-Methylhonokiol sameAs 4-O-Metilhonokiol.
- 4-O-Methylhonokiol sameAs Q4637186.
- 4-O-Methylhonokiol sameAs Q4637186.
- 4-O-Methylhonokiol wasDerivedFrom 4-O-Methylhonokiol?oldid=679453159.
- 4-O-Methylhonokiol depiction Methylhonokiol.svg.
- 4-O-Methylhonokiol isPrimaryTopicOf 4-O-Methylhonokiol.
- 4-O-Methylhonokiol name "4-O-Methylhonokiol".