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3,4-Diaminopyridine abstract "3,4-Diaminopyridine (or 3,4-DAP) is an organic compound with the formula C5H3N(NH2)2. It is formally derived from pyridine by substitution of the 3 and 4 positions with an amino group.The compound 3,4-diaminopyridine has the International Nonproprietary Name amifampridine and is used as a drug, predominantly in the treatment of a number of rare muscle diseases. The phosphate salt of amifampridine is a more stable formulation that does not require refrigeration; it is marketed in the EU by BioMarin Pharmaceutical under the trade name Firdapse and designated as an orphan drug in the EU. In the United States, amifampridine is under investigation for the treatment of Lambert-Eaton myasthenic syndrome by Catalyst Pharmaceuticals, and was granted a breakthrough therapy designation by the FDA in 2013. In a Phase 3 clinical trial, it demonstrated superiority over placebo in both co-primary endpoints. LEMS patients can receive amifampridine at no cost under an ongoing expanded access program. A study to develop patient entry criteria for a clinical trial of the free base form of amifampridine has also been completed by Jacobus Pharmaceutical Company. This form remains available at no cost to patients with Lambert-Eaton myasthenic syndrome and congenital myasthenic syndromes under a long-standing compassionate use program, with FDA oversight, from Jacobus Pharmaceutical Company (see also Uses and Cost, below).".
3,4-Diaminopyridine atcPrefix "N07".
3,4-Diaminopyridine atcSuffix "XX05".
3,4-Diaminopyridine bioavailability "30.0".
3,4-Diaminopyridine casNumber "54-96-6".
3,4-Diaminopyridine fdaUniiCode "RU4S6E2G0J".
3,4-Diaminopyridine iupacName "3,4-Diaminopyridine".
3,4-Diaminopyridine pubchem "5918".
3,4-Diaminopyridine thumbnail Diaminopyridine.png?width=300.
3,4-Diaminopyridine wikiPageID "8252883".
3,4-Diaminopyridine wikiPageLength "13255".
3,4-Diaminopyridine wikiPageOutDegree "29".
3,4-Diaminopyridine wikiPageRevisionID "673483366".
3,4-Diaminopyridine wikiPageWikiLink 4-Aminopyridine.
3,4-Diaminopyridine wikiPageWikiLink Acetylcholine.
3,4-Diaminopyridine wikiPageWikiLink Acetylcholine_receptor.
3,4-Diaminopyridine wikiPageWikiLink Amine.
3,4-Diaminopyridine wikiPageWikiLink Amino_group.
3,4-Diaminopyridine wikiPageWikiLink BioMarin_Pharmaceutical.
3,4-Diaminopyridine wikiPageWikiLink Catalyst_Pharmaceuticals.
3,4-Diaminopyridine wikiPageWikiLink Category:Aromatic_amines.
3,4-Diaminopyridine wikiPageWikiLink Category:Orphan_drugs.
3,4-Diaminopyridine wikiPageWikiLink Category:Potassium_channel_blockers.
3,4-Diaminopyridine wikiPageWikiLink Category:Pyridines.
3,4-Diaminopyridine wikiPageWikiLink Chemical_formula.
3,4-Diaminopyridine wikiPageWikiLink Choline_acetyltransferase.
3,4-Diaminopyridine wikiPageWikiLink Cochrane_Collaboration.
3,4-Diaminopyridine wikiPageWikiLink Compassionate_use.
3,4-Diaminopyridine wikiPageWikiLink Congenital_myasthenic_syndrome.
3,4-Diaminopyridine wikiPageWikiLink David_Cameron.
3,4-Diaminopyridine wikiPageWikiLink Dok-7.
3,4-Diaminopyridine wikiPageWikiLink Expanded_access.
3,4-Diaminopyridine wikiPageWikiLink International_Nonproprietary_Name.
3,4-Diaminopyridine wikiPageWikiLink Lambert-Eaton_myasthenic_syndrome.
3,4-Diaminopyridine wikiPageWikiLink Lambert–Eaton_myasthenic_syndrome.
3,4-Diaminopyridine wikiPageWikiLink Multiple_sclerosis.
3,4-Diaminopyridine wikiPageWikiLink Organic_compound.
3,4-Diaminopyridine wikiPageWikiLink Orphan_drug.
3,4-Diaminopyridine wikiPageWikiLink Potassium_channel.
3,4-Diaminopyridine wikiPageWikiLink Pyridine.
3,4-Diaminopyridine wikiPageWikiLink Systematic_review.
3,4-Diaminopyridine wikiPageWikiLink Voltage-dependent_calcium_channel.
3,4-Diaminopyridine wikiPageWikiLink Voltage_dependent_calcium_channel.
3,4-Diaminopyridine wikiPageWikiLinkText "3,4-Diaminopyridine".
3,4-Diaminopyridine wikiPageWikiLinkText "3,4-diaminopyridine".
3,4-Diaminopyridine atcPrefix "N07".
3,4-Diaminopyridine atcSuffix "XX05".
3,4-Diaminopyridine bioavailability "30.0".
3,4-Diaminopyridine c "5".
3,4-Diaminopyridine casNumber "54".
3,4-Diaminopyridine chembl "354077".
3,4-Diaminopyridine chemspiderid "5705".
3,4-Diaminopyridine h "7".
3,4-Diaminopyridine hasPhotoCollection 3,4-Diaminopyridine.
3,4-Diaminopyridine image "34".
3,4-Diaminopyridine inchi "1".
3,4-Diaminopyridine inchikey "OYTKINVCDFNREN-UHFFFAOYAR".
3,4-Diaminopyridine iupacName "34".
3,4-Diaminopyridine iupharLigand "8032".
3,4-Diaminopyridine legalUk "POM".
3,4-Diaminopyridine n "3".
3,4-Diaminopyridine pubchem "5918".
3,4-Diaminopyridine routesOfAdministration "Oral".
3,4-Diaminopyridine smiles "c1cnccN".
3,4-Diaminopyridine stdinchi "1".
3,4-Diaminopyridine stdinchikey "OYTKINVCDFNREN-UHFFFAOYSA-N".
3,4-Diaminopyridine tradename "Firdapse".
3,4-Diaminopyridine unii "RU4S6E2G0J".
3,4-Diaminopyridine verifiedfields "changed".
3,4-Diaminopyridine verifiedrevid "477217342".
3,4-Diaminopyridine width "120".
3,4-Diaminopyridine wikiPageUsesTemplate Template:Drugbox.
3,4-Diaminopyridine wikiPageUsesTemplate Template:Potassium_channel_blockers.
3,4-Diaminopyridine wikiPageUsesTemplate Template:Reflist.
3,4-Diaminopyridine subject Category:Aromatic_amines.
3,4-Diaminopyridine subject Category:Orphan_drugs.
3,4-Diaminopyridine subject Category:Potassium_channel_blockers.
3,4-Diaminopyridine subject Category:Pyridines.
3,4-Diaminopyridine hypernym Compound.
3,4-Diaminopyridine type ChemicalCompound.
3,4-Diaminopyridine type ChemicalSubstance.
3,4-Diaminopyridine type Drug.
3,4-Diaminopyridine type ChemicalObject.
3,4-Diaminopyridine type Thing.
3,4-Diaminopyridine type Q8386.
3,4-Diaminopyridine comment "3,4-Diaminopyridine (or 3,4-DAP) is an organic compound with the formula C5H3N(NH2)2. It is formally derived from pyridine by substitution of the 3 and 4 positions with an amino group.The compound 3,4-diaminopyridine has the International Nonproprietary Name amifampridine and is used as a drug, predominantly in the treatment of a number of rare muscle diseases.".
3,4-Diaminopyridine label "3,4-Diaminopyridine".
3,4-Diaminopyridine sameAs Amifampridin.
3,4-Diaminopyridine sameAs ۳و۴-دی_آمینو_پیریدین.
3,4-Diaminopyridine sameAs Amifampridine.
3,4-Diaminopyridine sameAs 3,4-Diaminopiridina.
3,4-Diaminopyridine sameAs 3,4-diaminopyridine.
3,4-Diaminopyridine sameAs m.026xy5n.
3,4-Diaminopyridine sameAs 3,4-Diaminopiridin.
3,4-Diaminopyridine sameAs 3,4-Diaminopiridin.
3,4-Diaminopyridine sameAs Q411707.
3,4-Diaminopyridine sameAs Q411707.
3,4-Diaminopyridine wasDerivedFrom 3,4-Diaminopyridine?oldid=673483366.
3,4-Diaminopyridine depiction Diaminopyridine.png.
3,4-Diaminopyridine isPrimaryTopicOf 3,4-Diaminopyridine.