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- 25CN-NBOH abstract "25CN-NBOH (or NBOH-2C-CN) is a compound indirectly derived from the phenethylamine series of hallucinogens, which was discovered in 2011 by Martin Hansen at the University of Copenhagen. This compound is notable as one of the most selective agonist ligands for the 5-HT2A receptor yet discovered, with a pKi of 8.88 at the human 5-HT2A receptor and with 100x selectivity for 5-HT2A over 5-HT2C, and 46x selectivity for 5-HT2A over 5-HT2B. In animal studies, 25CN-NBOH was found to partially substitute for DOI but was considerably weaker at inducing a head-twitch response in mice. The tendency of the 4-cyano substitution to confer high 5-HT2A selectivity had previously been observed with DOCN, but this was not sufficiently potent to be widely adopted as a research ligand. 25CN-NBOH is still slightly less selective for 5-HT2A than the more complex cyclised derivative 2S,6S-DMBMPP ((2S,6S)-2-(2,5-dimethoxy-4-bromobenzyl)-6-(2-methoxyphenyl)piperidine), however it is also less complex to synthesise and has higher efficacy as a partial agonist of the 5-HT2A receptor.".
- 25CN-NBOH casNumber "1391489-32-9".
- 25CN-NBOH iupacName "2-([2-(4-cyano-2,5-dimethoxyphenyl)ethylamino]methyl)phenol".
- 25CN-NBOH thumbnail NBOH-2CCN_structure.png?width=300.
- 25CN-NBOH wikiPageID "41055527".
- 25CN-NBOH wikiPageLength "4321".
- 25CN-NBOH wikiPageOutDegree "16".
- 25CN-NBOH wikiPageRevisionID "678501493".
- 25CN-NBOH wikiPageWikiLink 2,5-Dimethoxy-4-iodoamphetamine.
- 25CN-NBOH wikiPageWikiLink 25B-NBOH.
- 25CN-NBOH wikiPageWikiLink 25C-NBOH.
- 25CN-NBOH wikiPageWikiLink 25I-NBOH.
- 25CN-NBOH wikiPageWikiLink 2S,6S-DMBMPP.
- 25CN-NBOH wikiPageWikiLink 5-HT2A_receptor.
- 25CN-NBOH wikiPageWikiLink Category:2C_(psychedelics).
- 25CN-NBOH wikiPageWikiLink Category:5-HT2A_agonists.
- 25CN-NBOH wikiPageWikiLink DMBMPP.
- 25CN-NBOH wikiPageWikiLink Dissociation_constant.
- 25CN-NBOH wikiPageWikiLink Hallucinogen.
- 25CN-NBOH wikiPageWikiLink Head-twitch_response.
- 25CN-NBOH wikiPageWikiLink Partial_agonist.
- 25CN-NBOH wikiPageWikiLink Phenethylamine.
- 25CN-NBOH wikiPageWikiLink Receptor_(biochemistry).
- 25CN-NBOH wikiPageWikiLink University_of_Copenhagen.
- 25CN-NBOH wikiPageWikiLink File:SS9b_structure.png.
- 25CN-NBOH wikiPageWikiLinkText "25CN-NBOH".
- 25CN-NBOH wikiPageWikiLinkText "2C-CN-NBOH".
- 25CN-NBOH c "18".
- 25CN-NBOH casNumber "1391489".
- 25CN-NBOH h "20".
- 25CN-NBOH hasPhotoCollection 25CN-NBOH.
- 25CN-NBOH iupacName "2".
- 25CN-NBOH legalStatus "Uncontrolled".
- 25CN-NBOH molecularWeight "312.362".
- 25CN-NBOH n "2".
- 25CN-NBOH o "3".
- 25CN-NBOH smiles "COc1ccccc1CCNCc2ccccc2O".
- 25CN-NBOH width "240".
- 25CN-NBOH wikiPageUsesTemplate Template:Clear-left.
- 25CN-NBOH wikiPageUsesTemplate Template:Drugbox.
- 25CN-NBOH wikiPageUsesTemplate Template:Hallucinogens.
- 25CN-NBOH wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- 25CN-NBOH wikiPageUsesTemplate Template:Reflist.
- 25CN-NBOH wikiPageUsesTemplate Template:Serotonergics.
- 25CN-NBOH subject Category:2C_(psychedelics).
- 25CN-NBOH subject Category:5-HT2A_agonists.
- 25CN-NBOH hypernym Compound.
- 25CN-NBOH type ChemicalCompound.
- 25CN-NBOH type ChemicalSubstance.
- 25CN-NBOH type Drug.
- 25CN-NBOH type ChemicalObject.
- 25CN-NBOH type Thing.
- 25CN-NBOH type Q8386.
- 25CN-NBOH comment "25CN-NBOH (or NBOH-2C-CN) is a compound indirectly derived from the phenethylamine series of hallucinogens, which was discovered in 2011 by Martin Hansen at the University of Copenhagen. This compound is notable as one of the most selective agonist ligands for the 5-HT2A receptor yet discovered, with a pKi of 8.88 at the human 5-HT2A receptor and with 100x selectivity for 5-HT2A over 5-HT2C, and 46x selectivity for 5-HT2A over 5-HT2B.".
- 25CN-NBOH label "25CN-NBOH".
- 25CN-NBOH sameAs m.0z6syk6.
- 25CN-NBOH sameAs NBOH-2C-CN.
- 25CN-NBOH sameAs NBOH-2C-CN.
- 25CN-NBOH sameAs Q15409371.
- 25CN-NBOH sameAs Q15409371.
- 25CN-NBOH wasDerivedFrom 25CN-NBOH?oldid=678501493.
- 25CN-NBOH depiction NBOH-2CCN_structure.png.
- 25CN-NBOH isPrimaryTopicOf 25CN-NBOH.