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- 2-Deoxy-D-glucose abstract "2-Deoxy-D-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such, it acts to competitively inhibit the production of glucose-6-PO4 from glucose at the phosphoglucoisomerase level. In most cells, glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate intracellularly (with exception of liver and kidney); thus, labeled forms of 2-deoxyglucose serve as a good marker for tissue glucose uptake and hexokinase activity. Many cancers have elevated glucose uptake and hexokinase levels. 2-Deoxyglucose labeled with tritium or carbon-14 has been a popular ligand for laboratory research in animal models, where distribution is assessed by tissue-slicing followed by autoradiography, sometimes in tandem with either conventional or electron microscopy.2-DG is uptaken by the glucose transporters of the cell. Therefore, cells with higher glucose uptake, for example tumor cells, have also a higher uptake of 2-DG. Since 2-DG hampers cell growth, its use as a tumor therapeutic has been suggested, and in fact, 2-DG is in clinical trials A recent clinical trial showed 2-DG can be tolerated at a dose of 63 mg/kg/day, however the observed cardiac side-effects (prolongation of the Q-T interval) at this dose and the fact that a majority of patients' (66%) cancer progressed casts doubt on the feasibility of this reagent for further clinical use. However, it is not completely clear how 2-DG inhibits cell growth. The fact that glycolysis is inhibited by 2-DG, seems not to be sufficient to explain why 2-DG treated cells stop growing Clinicians have noted that 2-DG is metabolised in the pentose phosphate pathway in red blood cells at least, although the significance of this for other cell types and for cancer treatment in general is unclear.Work on the ketogenic diet as a treatment for epilepsy have investigated the role of glycolysis in the disease. 2-Deoxyglucose has been proposed by Garriga-Canut et al. as a mimic for the ketogenic diet, and shows great promise as a new anti-epileptic drug. The authors suggest that 2-DG works, in part, by increasing the expression of Brain-derived neurotrophic factor (BDNF), Nerve growth factor (NGF), Arc (protein) (ARC), and Basic fibroblast growth factor (FGF2). Such uses are complicated by the fact that 2-deoxyglucose does have some toxicity.2-DG has been used as a targeted optical imaging agent for fluorescent in vivo imaging. In clinical medical imaging (PET scanning), fluorodeoxyglucose is used, where one of the 2-hydrogens of 2-deoxy-D-glucose is replaced with the positron-emitting isotope fluorine-18, which emits paired gamma rays, allowing distribution of the tracer to be imaged by external gamma camera(s). This is increasingly done in tandem with a CT function which is part of the same PET/CT machine, to allow better localization of small-volume tissue glucose-uptake differences.".
- 2-Deoxy-D-glucose iupacName "(4R,5S,6R)-6-(hydroxymethyl)oxane-2,4,5-triol".
- 2-Deoxy-D-glucose thumbnail 2-Deoxy-D-glucose.png?width=300.
- 2-Deoxy-D-glucose wikiPageID "6016739".
- 2-Deoxy-D-glucose wikiPageLength "7275".
- 2-Deoxy-D-glucose wikiPageOutDegree "28".
- 2-Deoxy-D-glucose wikiPageRevisionID "678181451".
- 2-Deoxy-D-glucose wikiPageWikiLink 2-deoxyglucose-6-phosphate.
- 2-Deoxy-D-glucose wikiPageWikiLink Arc_(protein).
- 2-Deoxy-D-glucose wikiPageWikiLink Autoradiograph.
- 2-Deoxy-D-glucose wikiPageWikiLink Basic_fibroblast_growth_factor.
- 2-Deoxy-D-glucose wikiPageWikiLink Brain-derived_neurotrophic_factor.
- 2-Deoxy-D-glucose wikiPageWikiLink CT_scan.
- 2-Deoxy-D-glucose wikiPageWikiLink Carbon-14.
- 2-Deoxy-D-glucose wikiPageWikiLink Category:Aldohexoses.
- 2-Deoxy-D-glucose wikiPageWikiLink Category:Deoxy_sugars.
- 2-Deoxy-D-glucose wikiPageWikiLink Computed_tomography.
- 2-Deoxy-D-glucose wikiPageWikiLink Convention_(norm).
- 2-Deoxy-D-glucose wikiPageWikiLink Conventional.
- 2-Deoxy-D-glucose wikiPageWikiLink Electron_microscope.
- 2-Deoxy-D-glucose wikiPageWikiLink Electron_microscopy.
- 2-Deoxy-D-glucose wikiPageWikiLink Epilepsy.
- 2-Deoxy-D-glucose wikiPageWikiLink Fludeoxyglucose_(18F).
- 2-Deoxy-D-glucose wikiPageWikiLink Fluorine-18.
- 2-Deoxy-D-glucose wikiPageWikiLink Fluorodeoxyglucose.
- 2-Deoxy-D-glucose wikiPageWikiLink Gamma_ray.
- 2-Deoxy-D-glucose wikiPageWikiLink Glucose.
- 2-Deoxy-D-glucose wikiPageWikiLink Glucose_transporter.
- 2-Deoxy-D-glucose wikiPageWikiLink Glycolysis.
- 2-Deoxy-D-glucose wikiPageWikiLink Hexokinase.
- 2-Deoxy-D-glucose wikiPageWikiLink Hydroxyl.
- 2-Deoxy-D-glucose wikiPageWikiLink Ketogenic_diet.
- 2-Deoxy-D-glucose wikiPageWikiLink Molecule.
- 2-Deoxy-D-glucose wikiPageWikiLink Neoplasm.
- 2-Deoxy-D-glucose wikiPageWikiLink Nerve_growth_factor.
- 2-Deoxy-D-glucose wikiPageWikiLink PET_scan.
- 2-Deoxy-D-glucose wikiPageWikiLink Positron_emission_tomography.
- 2-Deoxy-D-glucose wikiPageWikiLink Tritium.
- 2-Deoxy-D-glucose wikiPageWikiLink Tumor.
- 2-Deoxy-D-glucose wikiPageWikiLinkText "2-Deoxy-D-glucose".
- 2-Deoxy-D-glucose hasPhotoCollection 2-Deoxy-D-glucose.
- 2-Deoxy-D-glucose imagefile "2".
- 2-Deoxy-D-glucose imagename "2".
- 2-Deoxy-D-glucose iupacname "-6".
- 2-Deoxy-D-glucose name "2".
- 2-Deoxy-D-glucose othernames "2".
- 2-Deoxy-D-glucose verifiedrevid "477213198".
- 2-Deoxy-D-glucose watchedfields "changed".
- 2-Deoxy-D-glucose wikiPageUsesTemplate Template:Chembox.
- 2-Deoxy-D-glucose wikiPageUsesTemplate Template:Citation_needed.
- 2-Deoxy-D-glucose subject Category:Aldohexoses.
- 2-Deoxy-D-glucose subject Category:Deoxy_sugars.
- 2-Deoxy-D-glucose hypernym Molecule.
- 2-Deoxy-D-glucose type Article.
- 2-Deoxy-D-glucose type ChemicalCompound.
- 2-Deoxy-D-glucose type ChemicalSubstance.
- 2-Deoxy-D-glucose type Article.
- 2-Deoxy-D-glucose type Carbohydrate.
- 2-Deoxy-D-glucose type Chemical.
- 2-Deoxy-D-glucose type ChemicalObject.
- 2-Deoxy-D-glucose type Thing.
- 2-Deoxy-D-glucose type Q11173.
- 2-Deoxy-D-glucose comment "2-Deoxy-D-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such, it acts to competitively inhibit the production of glucose-6-PO4 from glucose at the phosphoglucoisomerase level.".
- 2-Deoxy-D-glucose label "2-Deoxy-D-glucose".
- 2-Deoxy-D-glucose sameAs 2-desoxi-D-glucosa.
- 2-Deoxy-D-glucose sameAs ۲-داکسی-دی-گلوکز.
- 2-Deoxy-D-glucose sameAs 2-デオキシ-D-グルコース.
- 2-Deoxy-D-glucose sameAs m.0fks86.
- 2-Deoxy-D-glucose sameAs 2-Dezoksi-D-glukoza.
- 2-Deoxy-D-glucose sameAs 2-Dezoksi-D-glukoza.
- 2-Deoxy-D-glucose sameAs Q3266534.
- 2-Deoxy-D-glucose sameAs Q3266534.
- 2-Deoxy-D-glucose wasDerivedFrom 2-Deoxy-D-glucose?oldid=678181451.
- 2-Deoxy-D-glucose depiction 2-Deoxy-D-glucose.png.
- 2-Deoxy-D-glucose isPrimaryTopicOf 2-Deoxy-D-glucose.
- 2-Deoxy-D-glucose name "2-Deoxy-(D)-glucose".