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- Α5IA abstract "α5IA (LS-193,268) is a nootropic drug invented in 2004 by a team working for Merck, Sharp and Dohme, which acts as a subtype-selective inverse agonist at the benzodiazepine binding site on the GABAA receptor. It binds to the α1, α2, α3 and α5 subtypes, but shows much higher efficacy at the α5 subtype, and acts either as a weak partial agonist or inverse agonist at the other subtypes, with its partial agonist effect at α2 likely to be responsible for the lack of anxiety produced by this drug when compared to older α5-preferring inverse agonists such as L-655,708.The α5 subtype is expressed predominantly in the hippocampus, an area of the brain involved with learning and memory, and activation of this subtype is thought to be largely responsible for producing the cognitive side effects displayed by many benzodiazepine and nonbenzodiazepine drugs, such as amnesia and difficulties with learning and memory. This led researchers to conclude that a drug acting as an inverse agonist at this subtype should have the opposite effect and enhance learning and memory.Older non-selective inverse agonists at the benzodiazepine site such as DMCM are associated with a range of other effects including anxiety and convulsions, but because α5IA acts specifically at the α5 subtype it produces nootropic effects in animal studies, yet without any significant anxiogenic or pro-convulsant effects. This gives α5IA the potential to be a useful drug either to be used alongside benzodiazepines to counteract their cognitive side effects, or by itself as a nootropic with possible applications in the treatment of Alzheimer's disease and other forms of dementia.".
- Α5IA atcPrefix "none".
- Α5IA casNumber "215874-86-5".
- Α5IA iupacName "3-​(5-​methylisoxazol-​3-​yl)-​6-​[(1-​methyl-​1H-​1,2,3-​triazol-​4-​yl)​methoxy]​[1,2,4]triazolo​[3,4-​a]phthalazine".
- Α5IA pubchem "6918451".
- Α5IA thumbnail Alpha5IA.png?width=300.
- Α5IA wikiPageID "19165927".
- Α5IA wikiPageLength "3497".
- Α5IA wikiPageOutDegree "34".
- Α5IA wikiPageRevisionID "666334103".
- Α5IA wikiPageWikiLink Alzheimers_disease.
- Α5IA wikiPageWikiLink Amnesia.
- Α5IA wikiPageWikiLink Anxiety.
- Α5IA wikiPageWikiLink Anxiogenic.
- Α5IA wikiPageWikiLink Basmisanil.
- Α5IA wikiPageWikiLink Benzodiazepine.
- Α5IA wikiPageWikiLink Category:GABAA_receptor_negative_allosteric_modulators.
- Α5IA wikiPageWikiLink Category:Isoxazoles.
- Α5IA wikiPageWikiLink Category:Nootropics.
- Α5IA wikiPageWikiLink Category:Phenol_ethers.
- Α5IA wikiPageWikiLink Category:Phthalazines.
- Α5IA wikiPageWikiLink Category:Triazoles.
- Α5IA wikiPageWikiLink Convulsion.
- Α5IA wikiPageWikiLink DMCM.
- Α5IA wikiPageWikiLink Dementia.
- Α5IA wikiPageWikiLink GABAA_receptor.
- Α5IA wikiPageWikiLink GABA_A_receptor.
- Α5IA wikiPageWikiLink GABRA1.
- Α5IA wikiPageWikiLink GABRA2.
- Α5IA wikiPageWikiLink GABRA3.
- Α5IA wikiPageWikiLink GABRA5.
- Α5IA wikiPageWikiLink Gamma-aminobutyric_acid_receptor_subunit_alpha-1.
- Α5IA wikiPageWikiLink Hippocampus.
- Α5IA wikiPageWikiLink Inverse_agonist.
- Α5IA wikiPageWikiLink L-655,708.
- Α5IA wikiPageWikiLink L-838,417.
- Α5IA wikiPageWikiLink Merck_&_Co..
- Α5IA wikiPageWikiLink Nonbenzodiazepine.
- Α5IA wikiPageWikiLink Nootropic.
- Α5IA wikiPageWikiLink PWZ-029.
- Α5IA wikiPageWikiLink Partial_agonist.
- Α5IA wikiPageWikiLink Receptor_(biochemistry).
- Α5IA wikiPageWikiLink Ro4938581.
- Α5IA wikiPageWikiLink TB-21007.
- Α5IA wikiPageWikiLinkText "α5IA".
- Α5IA atcPrefix "none".
- Α5IA c "17".
- Α5IA casNumber "215874".
- Α5IA chemspiderid "5293648".
- Α5IA h "14".
- Α5IA hasPhotoCollection Α5IA.
- Α5IA imagename "α5IA".
- Α5IA iupacName "3".
- Α5IA molecularWeight "362.345".
- Α5IA n "8".
- Α5IA o "2".
- Α5IA pubchem "6918451".
- Α5IA smiles "c4nnnc4COc5c1ccccc1c2nnc-cnoc3C".
- Α5IA wikiPageUsesTemplate Template:Drugbox.
- Α5IA wikiPageUsesTemplate Template:GABAergics.
- Α5IA wikiPageUsesTemplate Template:Lowercase.
- Α5IA wikiPageUsesTemplate Template:Nootropics.
- Α5IA wikiPageUsesTemplate Template:Reflist.
- Α5IA subject Category:GABAA_receptor_negative_allosteric_modulators.
- Α5IA subject Category:Isoxazoles.
- Α5IA subject Category:Nootropics.
- Α5IA subject Category:Phenol_ethers.
- Α5IA subject Category:Phthalazines.
- Α5IA subject Category:Triazoles.
- Α5IA type ChemicalSubstance.
- Α5IA type Drug.
- Α5IA type ChemicalObject.
- Α5IA type Thing.
- Α5IA type Q8386.
- Α5IA comment "α5IA (LS-193,268) is a nootropic drug invented in 2004 by a team working for Merck, Sharp and Dohme, which acts as a subtype-selective inverse agonist at the benzodiazepine binding site on the GABAA receptor.".
- Α5IA label "Α5IA".
- Α5IA sameAs m.04lhgsz.
- Α5IA sameAs Α5IA.
- Α5IA sameAs Α5IA.
- Α5IA sameAs Q8083967.
- Α5IA sameAs Q8083967.
- Α5IA wasDerivedFrom Α5IA?oldid=666334103.
- Α5IA depiction Alpha5IA.png.
- Α5IA isPrimaryTopicOf Α5IA.