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- Rho-associated_protein_kinase abstract "Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.ROCKs (ROCK1 and ROCK2) occur in mammals (human, rat, mouse, cow), zebrafish, Xenopus, invertebrates (C. elegans, Mosquito, Drosophila) and chicken. Human ROCK1 has a molecular mass of 158 kDa and is a major downstream effector of the small GTPase RhoA. Mammalian ROCK consists of a kinase domain, a coiled-coil region and a Pleckstrin homology (PH) domain, which reduces the kinase activity of ROCKs by an autoinhibitory intramolecular fold if RhoA-GTP is not present.Rat ROCKs were discovered as the first effectors of Rho and they induce the formation of stress fibers and focal adhesions by phosphorylating MLC (myosin light chain).Due to this phosphorylation, the actin binding of myosin II and, thus, the contractility increases. Two mouse ROCK isoforms ROCK1 and ROCK2 have been identified. ROCK1 is mainly expressed in the lung, liver, spleen, kidney and testis. However, ROCK2 is distributed mostly in the brain and heart.".
- Rho-associated_protein_kinase arm "p".
- Rho-associated_protein_kinase band "24".
- Rho-associated_protein_kinase ecNumber "2.7.11.1".
- Rho-associated_protein_kinase entrezgene "579202".
- Rho-associated_protein_kinase entrezgene "6093".
- Rho-associated_protein_kinase entrezgene "9475".
- Rho-associated_protein_kinase hgncid "10251".
- Rho-associated_protein_kinase hgncid "10252".
- Rho-associated_protein_kinase locusSupplementaryData "-q32".
- Rho-associated_protein_kinase omim "601702".
- Rho-associated_protein_kinase omim "604002".
- Rho-associated_protein_kinase refseq "NM_004850".
- Rho-associated_protein_kinase refseq "NM_005406".
- Rho-associated_protein_kinase symbol "ROCK1".
- Rho-associated_protein_kinase symbol "ROCK2".
- Rho-associated_protein_kinase symbol "Rho-associated protein kinase".
- Rho-associated_protein_kinase symbol "Rho-associated, coiled-coil-containing protein kinase".
- Rho-associated_protein_kinase thumbnail 3d9v_bio_r_500.jpg?width=300.
- Rho-associated_protein_kinase uniprot "O75116".
- Rho-associated_protein_kinase uniprot "Q13464".
- Rho-associated_protein_kinase wikiPageID "27388475".
- Rho-associated_protein_kinase wikiPageRevisionID "602006163".
- Rho-associated_protein_kinase altsymbols "Rho kinase".
- Rho-associated_protein_kinase altsymbols "Rho-associated, coiled-coil-containing protein kinase".
- Rho-associated_protein_kinase arm "p".
- Rho-associated_protein_kinase band "24".
- Rho-associated_protein_kinase caption "Crystal structure of human ROCK I".
- Rho-associated_protein_kinase ecnumber "2.7".
- Rho-associated_protein_kinase entrezgene "579202".
- Rho-associated_protein_kinase entrezgene "6093".
- Rho-associated_protein_kinase entrezgene "9475".
- Rho-associated_protein_kinase hasPhotoCollection Rho-associated_protein_kinase.
- Rho-associated_protein_kinase hgncid "10251".
- Rho-associated_protein_kinase hgncid "10252".
- Rho-associated_protein_kinase locussupplementarydata "-q32".
- Rho-associated_protein_kinase name "ROCK".
- Rho-associated_protein_kinase name "Rho-associated, coiled-coil-containing protein kinase 1".
- Rho-associated_protein_kinase name "Rho-associated, coiled-coil-containing protein kinase 2".
- Rho-associated_protein_kinase omim "601702".
- Rho-associated_protein_kinase omim "604002".
- Rho-associated_protein_kinase refseq "NM_004850".
- Rho-associated_protein_kinase refseq "NM_005406".
- Rho-associated_protein_kinase symbol ROCK1.
- Rho-associated_protein_kinase symbol "ROCK2".
- Rho-associated_protein_kinase symbol "Rho-associated protein kinase".
- Rho-associated_protein_kinase uniprot "O75116".
- Rho-associated_protein_kinase uniprot "Q13464".
- Rho-associated_protein_kinase subject Category:Animal_genes.
- Rho-associated_protein_kinase subject Category:Animal_proteins.
- Rho-associated_protein_kinase subject Category:Cell_cycle.
- Rho-associated_protein_kinase type Abstraction100002137.
- Rho-associated_protein_kinase type Arrangement107938773.
- Rho-associated_protein_kinase type Chemical114806838.
- Rho-associated_protein_kinase type Compound114818238.
- Rho-associated_protein_kinase type Gene105436752.
- Rho-associated_protein_kinase type Genes.
- Rho-associated_protein_kinase type Group100031264.
- Rho-associated_protein_kinase type Macromolecule114944888.
- Rho-associated_protein_kinase type Material114580897.
- Rho-associated_protein_kinase type Matter100020827.
- Rho-associated_protein_kinase type Molecule114682133.
- Rho-associated_protein_kinase type Ordering108456993.
- Rho-associated_protein_kinase type OrganicCompound114727670.
- Rho-associated_protein_kinase type Part113809207.
- Rho-associated_protein_kinase type PhysicalEntity100001930.
- Rho-associated_protein_kinase type Protein114728724.
- Rho-associated_protein_kinase type Proteins.
- Rho-associated_protein_kinase type Relation100031921.
- Rho-associated_protein_kinase type Sequence108459252.
- Rho-associated_protein_kinase type Series108457976.
- Rho-associated_protein_kinase type Substance100019613.
- Rho-associated_protein_kinase type Thing100002452.
- Rho-associated_protein_kinase type Unit109465459.
- Rho-associated_protein_kinase type Biomolecule.
- Rho-associated_protein_kinase type Protein.
- Rho-associated_protein_kinase type BiologicalObject.
- Rho-associated_protein_kinase comment "Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.ROCKs (ROCK1 and ROCK2) occur in mammals (human, rat, mouse, cow), zebrafish, Xenopus, invertebrates (C. elegans, Mosquito, Drosophila) and chicken. Human ROCK1 has a molecular mass of 158 kDa and is a major downstream effector of the small GTPase RhoA.".
- Rho-associated_protein_kinase label "Rho-associated protein kinase".
- Rho-associated_protein_kinase sameAs m.02ptlhv.
- Rho-associated_protein_kinase sameAs Q3739041.
- Rho-associated_protein_kinase sameAs Q3739041.
- Rho-associated_protein_kinase sameAs Rho-associated_protein_kinase.
- Rho-associated_protein_kinase wasDerivedFrom Rho-associated_protein_kinase?oldid=602006163.
- Rho-associated_protein_kinase depiction 3d9v_bio_r_500.jpg.
- Rho-associated_protein_kinase isPrimaryTopicOf Rho-associated_protein_kinase.
- Rho-associated_protein_kinase name "ROCK".
- Rho-associated_protein_kinase name "Rho-associated, coiled-coil-containing protein kinase 1".
- Rho-associated_protein_kinase name "Rho-associated, coiled-coil-containing protein kinase 2".