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- Ras-GRF1 abstract "Ras-GRF1 is a guanine nucleotide exchange factor. Its function is to release guanosine diphosphate, GDP, from the signaling protein RAS, thus increasing the activity of RAS by allowing it to bind to guanosine triphosphate, GTP, returning it to its active state. In this way, Ras-GRF1 has a key role in regulating the RAS signaling pathway. Ras-GRF1 knockout mice have been shown to have learning and memory deficits associated with dysregulation of this pathway. Ras-GRF1 has also been shown to be upstream from IGF1, allowing it to control growth in mice. Although it is sometimes known as CDC25, it should not be confused with Cdc25. Ras-GRF1 is a paternally expressed imprinted gene, meaning that only the paternal allele of the gene is translated into protein. Disruption of this epigenetic imprinting also produces learning and memory deficits in neonatal mice.".
- Ras-GRF1 arm "q".
- Ras-GRF1 band "24".
- Ras-GRF1 chromosome "15".
- Ras-GRF1 entrezgene "5923".
- Ras-GRF1 hgncid "9875".
- Ras-GRF1 omim "606600".
- Ras-GRF1 refseq "NM_153815".
- Ras-GRF1 symbol "GRF1".
- Ras-GRF1 symbol "RASGRF1".
- Ras-GRF1 uniprot "Q13972".
- Ras-GRF1 wikiPageID "9848101".
- Ras-GRF1 wikiPageRevisionID "540119999".
- Ras-GRF1 altsymbols "GRF1".
- Ras-GRF1 arm "q".
- Ras-GRF1 band "24".
- Ras-GRF1 chromosome "15".
- Ras-GRF1 entrezgene "5923".
- Ras-GRF1 hasPhotoCollection Ras-GRF1.
- Ras-GRF1 hgncid "9875".
- Ras-GRF1 name "Ras protein-specific guanine nucleotide-releasing factor 1".
- Ras-GRF1 omim "606600".
- Ras-GRF1 refseq "NM_153815".
- Ras-GRF1 symbol "RASGRF1".
- Ras-GRF1 uniprot "Q13972".
- Ras-GRF1 type Biomolecule.
- Ras-GRF1 type Protein.
- Ras-GRF1 type ProteinMolecule.
- Ras-GRF1 type BiologicalObject.
- Ras-GRF1 comment "Ras-GRF1 is a guanine nucleotide exchange factor. Its function is to release guanosine diphosphate, GDP, from the signaling protein RAS, thus increasing the activity of RAS by allowing it to bind to guanosine triphosphate, GTP, returning it to its active state. In this way, Ras-GRF1 has a key role in regulating the RAS signaling pathway. Ras-GRF1 knockout mice have been shown to have learning and memory deficits associated with dysregulation of this pathway.".
- Ras-GRF1 label "Ras-GRF1".
- Ras-GRF1 sameAs m.02pts3n.
- Ras-GRF1 sameAs Q7294620.
- Ras-GRF1 sameAs Q7294620.
- Ras-GRF1 wasDerivedFrom Ras-GRF1?oldid=540119999.
- Ras-GRF1 isPrimaryTopicOf Ras-GRF1.
- Ras-GRF1 name "Ras protein-specific guanine nucleotide-releasing factor 1".