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- Phenoperidine abstract "Phenoperidine was discovered by Janssen Pharmaceutica 1960. Marketed as its hydrochloride as Operidine or Lealgin, is an opioid used as a general anesthetic. It is a derivative of isonipecotic acid, like pethidine, and is metabolized in part to norpethidine. It is 20-200 times as potent as pethidine as an analgesic. The greatly increased potency essentially eliminates the toxic effects of norpethidine accumulation which are seen when pethidine is administered in high doses or for long periods of time. In humans 1 milligram is equipotent with 10 mg morphine. It has less effect on the circulatory system and is less hypnotic than morphine, but it has about the same emetic effect. The nausea can be prevented by giving droperidol or haloperidol. After an intravenous dose the analgesia sets in after 3–5 minutes.Phenoperidine shares structural similarities with both pethidine and haloperidol (and related butyrophenone antipsychotics, e.g. droperidol). While not commonly used today in clinical practice, it is of historical interest as a precursor in the development of some of the most widely used neuroleptic drugs on the market today.".
- Phenoperidine atcPrefix "N01".
- Phenoperidine atcSuffix "AH04".
- Phenoperidine casNumber "562-26-5".
- Phenoperidine fdaUniiCode "G9BH09J4JW".
- Phenoperidine iupacName "ethyl 1-(3-hydroxy-3-phenylpropyl)-4-phenylpiperidine-4-carboxylate".
- Phenoperidine pubchem "11226".
- Phenoperidine thumbnail Phenoperidine.svg?width=300.
- Phenoperidine wikiPageExternalLink show_pathway?map07028+D02611.
- Phenoperidine wikiPageID "6149878".
- Phenoperidine wikiPageRevisionID "583037828".
- Phenoperidine atcPrefix "N01".
- Phenoperidine atcSuffix "AH04".
- Phenoperidine c "23".
- Phenoperidine casNumber "562".
- Phenoperidine chemspiderid "10752".
- Phenoperidine excretion "Bile and Urine".
- Phenoperidine h "29".
- Phenoperidine hasPhotoCollection Phenoperidine.
- Phenoperidine inchi "1".
- Phenoperidine inchikey "IPOPQVVNCFQFRK-UHFFFAOYAR".
- Phenoperidine iupacName "ethyl 1--4-phenylpiperidine-4-carboxylate".
- Phenoperidine kegg "D02611".
- Phenoperidine legalAu "S8".
- Phenoperidine legalUs "Schedule I".
- Phenoperidine metabolism Liver.
- Phenoperidine molecularWeight "367.481".
- Phenoperidine n "1".
- Phenoperidine o "3".
- Phenoperidine pubchem "11226".
- Phenoperidine routesOfAdministration Intravenous_therapy.
- Phenoperidine smiles "OCCCNCCC2OC=O".
- Phenoperidine stdinchi "1".
- Phenoperidine stdinchikey "IPOPQVVNCFQFRK-UHFFFAOYSA-N".
- Phenoperidine unii "G9BH09J4JW".
- Phenoperidine verifiedfields "changed".
- Phenoperidine verifiedrevid "464200540".
- Phenoperidine watchedfields "changed".
- Phenoperidine width "200".
- Phenoperidine subject Category:Alcohols.
- Phenoperidine subject Category:Carboxylate_esters.
- Phenoperidine subject Category:Ethyl_esters.
- Phenoperidine subject Category:General_anesthetics.
- Phenoperidine subject Category:Mu-opioid_agonists.
- Phenoperidine subject Category:Piperidines.
- Phenoperidine type Abstraction100002137.
- Phenoperidine type Agent114778436.
- Phenoperidine type Alcohol107884567.
- Phenoperidine type Alcohols.
- Phenoperidine type Beverage107881800.
- Phenoperidine type CarboxylateEsters.
- Phenoperidine type CausalAgent100007347.
- Phenoperidine type Chemical114806838.
- Phenoperidine type Compound114818238.
- Phenoperidine type Drug103247620.
- Phenoperidine type DrugOfAbuse103248958.
- Phenoperidine type Ester114850483.
- Phenoperidine type EthylEsters.
- Phenoperidine type Fluid114939900.
- Phenoperidine type Food100021265.
- Phenoperidine type Liquid114940386.
- Phenoperidine type Material114580897.
- Phenoperidine type Matter100020827.
- Phenoperidine type OrganicCompound114727670.
- Phenoperidine type Part113809207.
- Phenoperidine type PhysicalEntity100001930.
- Phenoperidine type Relation100031921.
- Phenoperidine type Substance100019613.
- Phenoperidine type Substance100020090.
- Phenoperidine type Drug.
- Phenoperidine type DrugProduct.
- Phenoperidine type FunctionalSubstance.
- Phenoperidine comment "Phenoperidine was discovered by Janssen Pharmaceutica 1960. Marketed as its hydrochloride as Operidine or Lealgin, is an opioid used as a general anesthetic. It is a derivative of isonipecotic acid, like pethidine, and is metabolized in part to norpethidine. It is 20-200 times as potent as pethidine as an analgesic.".
- Phenoperidine label "Fenoperydyna".
- Phenoperidine label "Phenoperidine".
- Phenoperidine sameAs Fenoperydyna.
- Phenoperidine sameAs m.0fssf8.
- Phenoperidine sameAs Q7181394.
- Phenoperidine sameAs Q7181394.
- Phenoperidine sameAs Phenoperidine.
- Phenoperidine wasDerivedFrom Phenoperidine?oldid=583037828.
- Phenoperidine depiction Phenoperidine.svg.
- Phenoperidine isPrimaryTopicOf Phenoperidine.