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- Parecoxib abstract "Parecoxib is a water soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. However, unlike ketorolac, parecoxib has no effect on platelet function and therefore does not promote bleeding during or after surgery. In addition, ketorolac has a much higher gastrointestinal toxicity profile compared to most other nonsteroidal antiinflammatory drugs (NSAIDs) including ibuprofen and naprosyn. However, in the United States ketorolac is the only injectable NSAID, although it is banned in many European countries due to concerns about surgical bleeding and stomach ulcers after surgery.In 2005, the U.S. Food and Drug Administration (FDA) issued a letter of non-approval for parecoxib in the United States. No reasons were ever documented publicly for the non-approval, although one study noted increased occurrences of heart attacks following cardiac bypass surgery compared to placebo when high doses of parecoxib were used to control pain after surgery. It is also important to remember that rare but severe allergic reactions (Stevens-Johnson Syndrome, Lyell Syndrome) have been described with valdecoxib, the molecule to which parecoxib is converted. The drug is not approved for use after cardiac surgery in Europe. Ketorolac, still banned in much of Europe, and IV Ibuprofen are therefore the only options for IV NSAIDs in the United States, and it is not clear whether parecoxib will be resubmitted to the FDA in the future.All antiiflammatory medications in the U.S. carry the same warning regarding skin reactions, and none are approved for use during CABG surgery, so the reason for the FDA denying the approval of parecoxib remains unknown, but was likely related to political pressure from the US Congress to not approve another COX-2 selective inhibitor in the wake of the Vioxx affair. No COX-2 selective inhibitor has been approved in the US since that time, regardless of the safety profile of parecoxib in Europe. Efforts to try and find out the scientific rationale, or more likely the lack thereof, that the FDA used to justify the non-approval of parecoxib in the USA have proven futile due to secrecy issues.".
- Parecoxib atcPrefix "M01".
- Parecoxib atcSuffix "AH04".
- Parecoxib bioavailability "100.0".
- Parecoxib casNumber "202409-33-4".
- Parecoxib chEBI "73038".
- Parecoxib drugbank "DB08439".
- Parecoxib fdaUniiCode "9TUW81Y3CE".
- Parecoxib iupacName "N-{[4-(5-methyl-3-phenylisoxazol-4-yl)phenyl]".
- Parecoxib iupacName "sulfonyl}propanamide".
- Parecoxib pubchem "119828".
- Parecoxib thumbnail Parecoxib.svg?width=300.
- Parecoxib wikiPageID "4982876".
- Parecoxib wikiPageRevisionID "603597621".
- Parecoxib atcPrefix "M01".
- Parecoxib atcSuffix "AH04".
- Parecoxib bioavailability "100.0".
- Parecoxib c "19".
- Parecoxib casNumber "202409".
- Parecoxib chebi "73038".
- Parecoxib chembl "1206690".
- Parecoxib chemspiderid "106990".
- Parecoxib drugbank "DB08439".
- Parecoxib eliminationHalfLife "1320.0".
- Parecoxib eliminationHalfLife "28800.0".
- Parecoxib excretion Kidney.
- Parecoxib h "18".
- Parecoxib hasPhotoCollection Parecoxib.
- Parecoxib inchi "1".
- Parecoxib inchikey "TZRHLKRLEZJVIJ-UHFFFAOYAA".
- Parecoxib iupacName "N-{[4-phenyl]".
- Parecoxib iupacName "sulfonyl}propanamide".
- Parecoxib legalAu "S4".
- Parecoxib legalUk "POM".
- Parecoxib licenceEu "Dynastat".
- Parecoxib metabolism "CYP extensively involved".
- Parecoxib metabolism "Hepatic to valdecoxib and propionic acid".
- Parecoxib molecularWeight "370.422".
- Parecoxib n "2".
- Parecoxib o "4".
- Parecoxib pregnancyCategory "Not recommended".
- Parecoxib proteinBound "98.0".
- Parecoxib pubchem "119828".
- Parecoxib routesOfAdministration "Intravenous and intramuscular".
- Parecoxib s "1".
- Parecoxib smiles "O=CCC".
- Parecoxib stdinchi "1".
- Parecoxib stdinchikey "TZRHLKRLEZJVIJ-UHFFFAOYSA-N".
- Parecoxib unii "9".
- Parecoxib verifiedfields "changed".
- Parecoxib verifiedrevid "464197422".
- Parecoxib subject Category:COX-2_inhibitors.
- Parecoxib subject Category:Isoxazoles.
- Parecoxib subject Category:Non-steroidal_anti-inflammatory_drugs.
- Parecoxib subject Category:Prodrugs.
- Parecoxib subject Category:Propionamides.
- Parecoxib type Agent114778436.
- Parecoxib type Anti-inflammatory102721538.
- Parecoxib type COX-2Inhibitors.
- Parecoxib type CausalAgent100007347.
- Parecoxib type Drug103247620.
- Parecoxib type Inhibitor114724436.
- Parecoxib type Matter100020827.
- Parecoxib type Medicine103740161.
- Parecoxib type Non-steroidalAnti-inflammatoryDrugs.
- Parecoxib type PhysicalEntity100001930.
- Parecoxib type Substance100020090.
- Parecoxib type Drug.
- Parecoxib type DrugProduct.
- Parecoxib type FunctionalSubstance.
- Parecoxib comment "Parecoxib is a water soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States.".
- Parecoxib label "Parecoxib".
- Parecoxib label "Parecoxib".
- Parecoxib label "Parecoxib".
- Parecoxib label "Parecoxib".
- Parecoxib label "Parécoxib".
- Parecoxib sameAs Parecoxib.
- Parecoxib sameAs Parécoxib.
- Parecoxib sameAs Parecoxib.
- Parecoxib sameAs Parecoxib.
- Parecoxib sameAs m.0cydks.
- Parecoxib sameAs Q347941.
- Parecoxib sameAs Q347941.
- Parecoxib sameAs Parecoxib.
- Parecoxib wasDerivedFrom Parecoxib?oldid=603597621.
- Parecoxib depiction Parecoxib.svg.
- Parecoxib isPrimaryTopicOf Parecoxib.