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- PHLPP abstract "The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells.PHLPP dephosphorylates Ser-473 (the hydrophobic motif) in Akt, thus partially inactivating the kinase.In addition, PHLPP dephosphorylates conventional and novel members of the protein kinase C family at their hydrophobic motifs, corresponding to Ser-660 in PKCβII.".
- PHLPP arm "q".
- PHLPP band "21.32".
- PHLPP band "22.2".
- PHLPP chromosome "16".
- PHLPP chromosome "18".
- PHLPP ecNumber "3.1.3.16".
- PHLPP entrezgene "23035".
- PHLPP entrezgene "23239".
- PHLPP hgncid "20610".
- PHLPP hgncid "29149".
- PHLPP omim "609396".
- PHLPP omim "611066".
- PHLPP refseq "NM_015020".
- PHLPP refseq "XM_166290".
- PHLPP symbol "PHLPP".
- PHLPP symbol "PHLPP1, PLEKHE1".
- PHLPP symbol "PHLPP2".
- PHLPP symbol "PHLPPL".
- PHLPP uniprot "O60346".
- PHLPP uniprot "Q6ZVD8".
- PHLPP wikiPageID "10292285".
- PHLPP wikiPageRevisionID "594718077".
- PHLPP altsymbols "PHLPP1, PLEKHE1".
- PHLPP altsymbols "PHLPP2".
- PHLPP arm "q".
- PHLPP band "21.32".
- PHLPP band "22.2".
- PHLPP chromosome "16".
- PHLPP chromosome "18".
- PHLPP ecnumber "3.1".
- PHLPP entrezgene "23035".
- PHLPP entrezgene "23239".
- PHLPP hasPhotoCollection PHLPP.
- PHLPP hgncid "20610".
- PHLPP hgncid "29149".
- PHLPP name PHLPPL.
- PHLPP name PHLPP_(gene).
- PHLPP omim "609396".
- PHLPP omim "611066".
- PHLPP refseq "NM_015020".
- PHLPP refseq "XM_166290".
- PHLPP symbol PHLPPL.
- PHLPP symbol PHLPP_(gene).
- PHLPP uniprot "O60346".
- PHLPP uniprot "Q6ZVD8".
- PHLPP subject Category:EC_3.1.3.
- PHLPP subject Category:Signal_transduction.
- PHLPP type Biomolecule.
- PHLPP type Protein.
- PHLPP type ProteinMolecule.
- PHLPP type BiologicalObject.
- PHLPP comment "The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms.".
- PHLPP label "PHLPP".
- PHLPP sameAs m.02q7lz3.
- PHLPP sameAs Q7119246.
- PHLPP sameAs Q7119246.
- PHLPP wasDerivedFrom PHLPP?oldid=594718077.
- PHLPP isPrimaryTopicOf PHLPP.
- PHLPP name "PH domain and leucine rich repeat protein phosphatase-like".
- PHLPP name "PH domain and leucine-rich repeat protein phosphatase".