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- MT-45 abstract "MT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opiate activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine). It has been used as a lead compound from which a large family of potent opioid drugs have been developed, including full agonists, partial agonists and antagonists at the three main opioid receptor subtypes.MT-45 could possibly be an agonist–antagonist at the opioid receptor, and possibly a mild NMDA receptor antagonist.[citation needed]".
- MT-45 atcPrefix "none".
- MT-45 casNumber "41537-67-1".
- MT-45 casSupplemental "52694-55-0 (S) enantiomer".
- MT-45 iupacName "1-cyclohexyl-4-(1,2-diphenylethyl)piperazine".
- MT-45 pubchem "431865".
- MT-45 thumbnail MT-45_structure.png?width=300.
- MT-45 wikiPageID "31291294".
- MT-45 wikiPageRevisionID "600660708".
- MT-45 atcPrefix "none".
- MT-45 c "24".
- MT-45 casNumber "41537".
- MT-45 casSupplemental "52694".
- MT-45 h "32".
- MT-45 hasPhotoCollection MT-45.
- MT-45 iupacName "1".
- MT-45 molecularWeight "348.523".
- MT-45 n "2".
- MT-45 pubchem "431865".
- MT-45 routesOfAdministration Oral_administration.
- MT-45 smiles "c3ccccc3CCNCCN1C4CCCCC4".
- MT-45 synonyms "MT-45, IC-6".
- MT-45 verifiedrevid "451607504".
- MT-45 width "180".
- MT-45 subject Category:Mu-opioid_agonists.
- MT-45 subject Category:Piperazines.
- MT-45 subject Category:Synthetic_opioids.
- MT-45 type Drug.
- MT-45 type FunctionalSubstance.
- MT-45 comment "MT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opiate activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine).".
- MT-45 label "MT-45".
- MT-45 sameAs m.0gjb_ts.
- MT-45 sameAs Q6718304.
- MT-45 sameAs Q6718304.
- MT-45 wasDerivedFrom MT-45?oldid=600660708.
- MT-45 depiction MT-45_structure.png.
- MT-45 isPrimaryTopicOf MT-45.