Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Dynorphin> ?p ?o }
Showing triples 1 to 64 of
64
with 100 triples per page.
- Dynorphin abstract "Dynorphins (Dyn) are a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neo-endorphin. Depolarization of a neuron containing prodynorphin stimulates PC2 processing, which occurs within synaptic vesicles in the presynaptic terminal. Occasionally, prodynorphin is not fully processed, leading to the release of “big dynorphin.” This 32-amino acid molecule consists of both dynorphin A and dynorphin B.Dynorphin A, dynorphin B, and big dynorphin all contain a high proportion of basic amino acid residues, in particular lysine and arginine (29.4%, 23.1%, and 31.2% basic residues, respectively), as well as many hydrophobic residues (41.2%, 30.8%, and 34.4% hydrophobic residues, respectively). Although dynorphins are found widely distributed in the CNS, they have the highest concentrations in the hypothalamus, medulla, pons, midbrain, and spinal cord. Dynorphins are stored in large (80-120 nm diameter) dense-core vesicles that are considerably larger than vesicles storing neurotransmitters. These large dense-core vesicles differ from small synaptic vesicles in that a more intense and prolonged stimulus is needed to cause the large vesicles to release their contents into the synaptic cleft. Dense-core vesicle storage is characteristic of opioid peptides storage.The first clues to the functionality of dynorphins came from Goldstein et al. in their work with opioid peptides. The group discovered an endogenous opioid peptide in the porcine pituitary that proved difficult to isolate. By sequencing the first 13 amino acids of the peptide, they created a synthetic version of the peptide with a similar potency to the natural peptide. Goldstein et al. applied the synthetic peptide to the guinea ileum longitudinal muscle and found it to be an extraordinarily potent opioid peptide. The peptide was called dynorphin (from the Greek dynamis=power) to describe its potency.Dynorphins exert their effects primarily through the κ-opioid receptor (KOR), a G-protein-coupled receptor. Two subtypes of KORs have been identified: K1 and K2. Although KOR is the primary receptor for all dynorphins, the peptides do have some affinity for the μ-opioid receptor (MOR), δ-opioid receptor (DOR),and the N-methyl-D-aspartic acid (NMDA)-type glutamate receptor. Different dynorphins show different receptor selectivities and potencies at receptors. Big dynorphin and dynorphin A have the same selectivity for human KOR, but dynorphin A is more selective for KOR over MOR and DOR than is big dynorphin. Big dynorphin is more potent at KORs than is dynorphin A. Both big dynorphin and dynorphin A are more potent and more selective than dynorphin B.".
- Dynorphin arm "p".
- Dynorphin band "ter".
- Dynorphin chromosome "20".
- Dynorphin entrezgene "5173".
- Dynorphin hgncid "8820".
- Dynorphin locusSupplementaryData "-p12.2".
- Dynorphin omim "131340".
- Dynorphin refseq "NM_024411".
- Dynorphin symbol "PDYN".
- Dynorphin uniprot "P01213".
- Dynorphin wikiPageExternalLink index.html?query=pdyn.
- Dynorphin wikiPageID "710793".
- Dynorphin wikiPageRevisionID "603315030".
- Dynorphin arm "p".
- Dynorphin band "ter".
- Dynorphin chromosome "20".
- Dynorphin entrezgene "5173".
- Dynorphin hasPhotoCollection Dynorphin.
- Dynorphin hgncid "8820".
- Dynorphin locussupplementarydata "-p12.2".
- Dynorphin name "prodynorphin".
- Dynorphin omim "131340".
- Dynorphin refseq "NM_024411".
- Dynorphin symbol "PDYN".
- Dynorphin uniprot "P01213".
- Dynorphin subject Category:Depressogenics.
- Dynorphin subject Category:Kappa_agonists.
- Dynorphin subject Category:Neurotransmitters.
- Dynorphin subject Category:Opioid_peptides.
- Dynorphin type Abstraction100002137.
- Dynorphin type Chemical114806838.
- Dynorphin type Compound114818238.
- Dynorphin type Material114580897.
- Dynorphin type Matter100020827.
- Dynorphin type Neurochemical114807410.
- Dynorphin type Neurotransmitter114807558.
- Dynorphin type Neurotransmitters.
- Dynorphin type OrganicCompound114727670.
- Dynorphin type Part113809207.
- Dynorphin type PhysicalEntity100001930.
- Dynorphin type Relation100031921.
- Dynorphin type Substance100019613.
- Dynorphin type Biomolecule.
- Dynorphin type Protein.
- Dynorphin type ProteinMolecule.
- Dynorphin type BiologicalObject.
- Dynorphin comment "Dynorphins (Dyn) are a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neo-endorphin. Depolarization of a neuron containing prodynorphin stimulates PC2 processing, which occurs within synaptic vesicles in the presynaptic terminal.".
- Dynorphin label "Dinorfine".
- Dynorphin label "Dynorfine".
- Dynorphin label "Dynorphin".
- Dynorphin label "Dynorphine".
- Dynorphin label "ダイノルフィン".
- Dynorphin sameAs Dynorphine.
- Dynorphin sameAs Dinorfine.
- Dynorphin sameAs ダイノルフィン.
- Dynorphin sameAs Dynorfine.
- Dynorphin sameAs m.034t_n.
- Dynorphin sameAs Q324076.
- Dynorphin sameAs Q324076.
- Dynorphin sameAs Dynorphin.
- Dynorphin wasDerivedFrom Dynorphin?oldid=603315030.
- Dynorphin isPrimaryTopicOf Dynorphin.
- Dynorphin name "prodynorphin".