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- Benzodiazepine_withdrawal_syndrome abstract "Benzodiazepine withdrawal syndrome—often abbreviated to benzo withdrawal—is the cluster of symptoms that emerge when a person who has taken benzodiazepines and has developed a physical dependence undergoes dosage reduction or discontinuation. It is characterized by often severe sleep disturbance, irritability, increased tension and anxiety, panic attacks, hand tremor, sweating, difficulty with concentration, confusion and cognitive difficulty, memory problems, dry retching and nausea, weight loss, palpitations, headache, muscular pain and stiffness, a host of perceptual changes, hallucinations, seizures, psychosis, and suicide (see "Signs and Symptoms" section below for full list). Further, these symptoms are notable for the manner in which they wax and wane and vary in severity from day to day or week by week instead of steadily decreasing in a straightforward linear manner.It is a potentially serious condition, and is complex and often protracted in time course. Not every long-term user will experience symptoms upon discontinuation, but the proportion of those who will has been variably estimated to be between 15% and 44%. Long-term use, defined as daily use for at least three months, is not desirable because of the associated increased risk of dependence, dose escalation, loss of efficacy, increased risk of accidents and falls, particularly for the elderly, as well as cognitive, neurological, and intellectual impairments. Use of short-acting hypnotics, while being effective at initiating sleep, worsen the second half of sleep due to withdrawal effects. Nevertheless, long-term users of benzodiazepines should not be forced to withdraw against their will.Benzodiazepine withdrawal is similar to alcohol and barbiturate withdrawal syndromes. It can be severe and provoke life-threatening withdrawal symptoms, such as seizures, particularly with abrupt or over-rapid dosage reduction from high doses or long time users. A severe withdrawal response can nevertheless occur despite gradual dose reduction, or from relatively low doses in short time users, even after a single large dose in animal models. A minority of individuals will experience a protracted withdrawal syndrome whose symptoms may persist at a sub-acute level for months, or years after cessation of benzodiazepines. The likelihood of developing a protracted withdrawal syndrome can be minimized by a slow, gradual reduction in dosage.Chronic exposure to benzodiazepines causes neural adaptations that counteract the drug's effects, leading to tolerance and dependence. Despite taking a constant therapeutic dose, long-term use of benzodiazepines may lead to the emergence of withdrawal-like symptoms, particularly between doses. When the drug is discontinued or the dosage reduced, withdrawal symptoms may appear and remain until the body reverses the physiological adaptations. These rebound symptoms may be identical to the symptoms for which the drug was initially taken, or may be part of discontinuation symptoms. In severe cases, the withdrawal reaction may exacerbate or resemble serious psychiatric and medical conditions, such as mania, schizophrenia, and, especially at high doses, seizure disorders. Failure to recognize discontinuation symptoms can lead to false evidence for the need to take benzodiazepines, which in turn leads to withdrawal failure and reinstatement of benzodiazepines, often to higher doses.Awareness of the withdrawal reactions, individualized taper strategies according to withdrawal severity, the addition of alternative strategies such as reassurance and referral to benzodiazepine withdrawal support groups, all increase the success rate of withdrawal.".
- Benzodiazepine_withdrawal_syndrome icd10 "F13.3".
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- Benzodiazepine_withdrawal_syndrome icd "F13.3".
- Benzodiazepine_withdrawal_syndrome name "Benzodiazepine withdrawal syndrome".
- Benzodiazepine_withdrawal_syndrome wordnet_type synset-disease-noun-1.
- Benzodiazepine_withdrawal_syndrome subject Category:Addiction_psychiatry.
- Benzodiazepine_withdrawal_syndrome subject Category:Adverse_effects_of_psychoactive_drugs.
- Benzodiazepine_withdrawal_syndrome subject Category:Benzodiazepines.
- Benzodiazepine_withdrawal_syndrome subject Category:Pharmacology.
- Benzodiazepine_withdrawal_syndrome subject Category:Substance_dependence.
- Benzodiazepine_withdrawal_syndrome subject Category:Withdrawal_syndromes.
- Benzodiazepine_withdrawal_syndrome type Abstraction100002137.
- Benzodiazepine_withdrawal_syndrome type Attribute100024264.
- Benzodiazepine_withdrawal_syndrome type Cognition100023271.
- Benzodiazepine_withdrawal_syndrome type Complex105870365.
- Benzodiazepine_withdrawal_syndrome type Concept105835747.
- Benzodiazepine_withdrawal_syndrome type Condition113920835.
- Benzodiazepine_withdrawal_syndrome type Content105809192.
- Benzodiazepine_withdrawal_syndrome type Disease114070360.
- Benzodiazepine_withdrawal_syndrome type Idea105833840.
- Benzodiazepine_withdrawal_syndrome type IllHealth114052046.
- Benzodiazepine_withdrawal_syndrome type Illness114061805.
- Benzodiazepine_withdrawal_syndrome type PathologicalState114051917.
- Benzodiazepine_withdrawal_syndrome type PhysicalCondition114034177.
- Benzodiazepine_withdrawal_syndrome type PsychologicalFeature100023100.
- Benzodiazepine_withdrawal_syndrome type State100024720.
- Benzodiazepine_withdrawal_syndrome type Syndrome105870790.
- Benzodiazepine_withdrawal_syndrome type Whole105869584.
- Benzodiazepine_withdrawal_syndrome type WithdrawalSyndromes.
- Benzodiazepine_withdrawal_syndrome type Disease.
- Benzodiazepine_withdrawal_syndrome type AilmentCondition.
- Benzodiazepine_withdrawal_syndrome type Situation.
- Benzodiazepine_withdrawal_syndrome comment "Benzodiazepine withdrawal syndrome—often abbreviated to benzo withdrawal—is the cluster of symptoms that emerge when a person who has taken benzodiazepines and has developed a physical dependence undergoes dosage reduction or discontinuation.".
- Benzodiazepine_withdrawal_syndrome label "Benzodiazepine withdrawal syndrome".
- Benzodiazepine_withdrawal_syndrome label "Síndrome de abstinencia de las benzodiazepinas".
- Benzodiazepine_withdrawal_syndrome label "ベンゾジアゼピン離脱症候群".
- Benzodiazepine_withdrawal_syndrome sameAs Síndrome_de_abstinencia_de_las_benzodiazepinas.
- Benzodiazepine_withdrawal_syndrome sameAs ベンゾジアゼピン離脱症候群.
- Benzodiazepine_withdrawal_syndrome sameAs m.02rnw7w.
- Benzodiazepine_withdrawal_syndrome sameAs Q6119887.
- Benzodiazepine_withdrawal_syndrome sameAs Q6119887.
- Benzodiazepine_withdrawal_syndrome sameAs Benzodiazepine_withdrawal_syndrome.
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- Benzodiazepine_withdrawal_syndrome depiction Diazepam2mgand5mgtablets.JPG.
- Benzodiazepine_withdrawal_syndrome isPrimaryTopicOf Benzodiazepine_withdrawal_syndrome.
- Benzodiazepine_withdrawal_syndrome name "Benzodiazepine withdrawal syndrome".