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- Q17021559 subject Q8508486.
- Q17021559 abstract "Hb Bassett is a hemoglobin variant that exhibits a very reduced oxygen affinity (Abdulmalik et al., 2004). Hb Bassett arises from a mutation at the alpha 94 (G1) position whereby aspartic acid is replaced by alanine (Abdulmalik et al., 2004). Hb Bassett is a disruption of the alpha1 and beta2 contact point (Voet and Voet, 2006, Abdulmalik et al., 2004). Hemoglobin of the Bassett variety has much higher P50 than normal hemoglobin. At pH 7, Hb Bassett has a P50 of approximately 22mmHg and normal hemoglobin has an approximate P50 of 10.5mmHg (Abdulmalik et al., 2004). In addition to high P50 values, Hb Bassett shows a reduced Bohr effect (reduced oxygen unloading) and low cooperativity (n=1.4) resulting in lower oxygen affinity (Abdulmalik et al., 2004). These factors conspire to produce a hemoglobin variant that does not provide sufficient oxygen and manifests itself as low oxygen saturation, episodes of cyanosis and anemia (Abdulmalik et al., 2004). The proposed explanation for Hb Bassett’s instability is loosening and destabilization of the hemoglobin R state (bound ligand [oxygen]) and a resulting shift in the equilibrium that exists between the two states towards the T state (unbound oxygen). The instability is localized at the interface between the two dimeric subunits of hemoglobin. The lack of bound oxygen in Hb Bassett homozygotes leads to the clinical outcome of cyanosis (they are cyanotic) (Abdulmalik et al., 2004).".
- Q17021559 wikiPageExternalLink ABSTRACT?CRETRY=1&SRETRY=0.
- Q17021559 wikiPageWikiLink Q13048280.
- Q17021559 wikiPageWikiLink Q17022368.
- Q17021559 wikiPageWikiLink Q192120.
- Q17021559 wikiPageWikiLink Q218642.
- Q17021559 wikiPageWikiLink Q43041.
- Q17021559 wikiPageWikiLink Q5445.
- Q17021559 wikiPageWikiLink Q8508486.
- Q17021559 wikiPageWikiLink Q890877.
- Q17021559 comment "Hb Bassett is a hemoglobin variant that exhibits a very reduced oxygen affinity (Abdulmalik et al., 2004). Hb Bassett arises from a mutation at the alpha 94 (G1) position whereby aspartic acid is replaced by alanine (Abdulmalik et al., 2004). Hb Bassett is a disruption of the alpha1 and beta2 contact point (Voet and Voet, 2006, Abdulmalik et al., 2004). Hemoglobin of the Bassett variety has much higher P50 than normal hemoglobin.".
- Q17021559 label "Hb Bassett".