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- Volcano_plot_(statistics) abstract "In statistics, a volcano plot is a type of scatter-plot that is used to quickly identify changes in large datasets composed of replicate data. It plots significance versus fold-change on the y- and x-axes, respectively. These plots are increasingly common in omic experiments such as genomics, proteomics, and metabolomics where one often has a list of many thousands of replicate datapoints between two conditions and one wishes to quickly identify the most-meaningful changes. A volcano plot combines a measure of statistical significance from a statistical test (e.g., a p-value from an ANOVA model) with the magnitude of the change enabling quick visual identification of those data-points (genes, etc.) that display large-magnitude changes that are also statistically significant.A volcano plot is constructed by plotting the negative log of the p-value on the y-axis (usually base 10). This results in datapoints with low p-values (highly significant) appearing toward the top of the plot. The x-axis is the log of the fold change between the two conditions. The log of the fold-change is used so that changes in both directions appear equidistant from the center. Plotting points in this way results in two regions of interest in the plot: those points that are found toward the top of the plot that are far to either the left- or the right-hand side. These represent values that display large magnitude fold changes (hence being left- or right- of center) as well as high statistical significance (hence being toward the top).Additional information can be added by coloring the points according to a third dimension of data (such as signal-intensity) but this is not uniformly employed. Volcano plot is also used to graphically display a significance analysis of microarrays (SAM) gene selection criterion, an example of regularization.The concept of volcano plot can be generalized to other applications, where the x-axis is related to a measure ofthe strength of a statistical signal, and y-axis is related to a measure of the statistical significance of the signal.For example, in a genetic association case-control study, such as Genome-wide association study,a point in a volcano plot represents a single-nucleotide polymorphism.Its x value can be the odds ratio and its y value can be -log10 of the p-value from Chi-square testor a Chi-square test statistic.".
- Volcano_plot_(statistics) thumbnail Volcano_eg.jpg?width=300.
- Volcano_plot_(statistics) wikiPageExternalLink Statistical.Tests.jsp.
- Volcano_plot_(statistics) wikiPageExternalLink mavolcanoplot.html.
- Volcano_plot_(statistics) wikiPageID "25668921".
- Volcano_plot_(statistics) wikiPageLength "4750".
- Volcano_plot_(statistics) wikiPageOutDegree "31".
- Volcano_plot_(statistics) wikiPageRevisionID "700105984".
- Volcano_plot_(statistics) wikiPageWikiLink Analysis_of_variance.
- Volcano_plot_(statistics) wikiPageWikiLink Cartesian_coordinate_system.
- Volcano_plot_(statistics) wikiPageWikiLink Case-control_study.
- Volcano_plot_(statistics) wikiPageWikiLink Category:Bioinformatics.
- Volcano_plot_(statistics) wikiPageWikiLink Category:Statistical_charts_and_diagrams.
- Volcano_plot_(statistics) wikiPageWikiLink Category:Statistical_methods.
- Volcano_plot_(statistics) wikiPageWikiLink Chi-squared_test.
- Volcano_plot_(statistics) wikiPageWikiLink Fold_change.
- Volcano_plot_(statistics) wikiPageWikiLink Genetic_association.
- Volcano_plot_(statistics) wikiPageWikiLink Genome-wide_association_study.
- Volcano_plot_(statistics) wikiPageWikiLink Genomics.
- Volcano_plot_(statistics) wikiPageWikiLink List_of_omics_topics_in_biology.
- Volcano_plot_(statistics) wikiPageWikiLink Metabolomics.
- Volcano_plot_(statistics) wikiPageWikiLink Odds_ratio.
- Volcano_plot_(statistics) wikiPageWikiLink P-value.
- Volcano_plot_(statistics) wikiPageWikiLink Proteomics.
- Volcano_plot_(statistics) wikiPageWikiLink Regularization_(mathematics).
- Volcano_plot_(statistics) wikiPageWikiLink Scatter_plot.
- Volcano_plot_(statistics) wikiPageWikiLink Significance_analysis_of_microarrays.
- Volcano_plot_(statistics) wikiPageWikiLink Single-nucleotide_polymorphism.
- Volcano_plot_(statistics) wikiPageWikiLink Statistical_significance.
- Volcano_plot_(statistics) wikiPageWikiLink Test_statistic.
- Volcano_plot_(statistics) wikiPageWikiLink File:Volcano_eg.jpg.
- Volcano_plot_(statistics) wikiPageWikiLinkText "Volcano plot (statistics)".
- Volcano_plot_(statistics) wikiPageWikiLinkText "volcano plot".
- Volcano_plot_(statistics) wikiPageUsesTemplate Template:Reflist.
- Volcano_plot_(statistics) wikiPageUsesTemplate Template:Statistics.
- Volcano_plot_(statistics) subject Category:Bioinformatics.
- Volcano_plot_(statistics) subject Category:Statistical_charts_and_diagrams.
- Volcano_plot_(statistics) subject Category:Statistical_methods.
- Volcano_plot_(statistics) hypernym Type.
- Volcano_plot_(statistics) type Biostatistic.
- Volcano_plot_(statistics) type Chart.
- Volcano_plot_(statistics) type Method.
- Volcano_plot_(statistics) comment "In statistics, a volcano plot is a type of scatter-plot that is used to quickly identify changes in large datasets composed of replicate data. It plots significance versus fold-change on the y- and x-axes, respectively. These plots are increasingly common in omic experiments such as genomics, proteomics, and metabolomics where one often has a list of many thousands of replicate datapoints between two conditions and one wishes to quickly identify the most-meaningful changes.".
- Volcano_plot_(statistics) label "Volcano plot (statistics)".
- Volcano_plot_(statistics) sameAs Q7940074.
- Volcano_plot_(statistics) sameAs m.09v0zvv.
- Volcano_plot_(statistics) sameAs Q7940074.
- Volcano_plot_(statistics) wasDerivedFrom Volcano_plot_(statistics)?oldid=700105984.
- Volcano_plot_(statistics) depiction Volcano_eg.jpg.
- Volcano_plot_(statistics) isPrimaryTopicOf Volcano_plot_(statistics).
