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- Synthesis-dependent_strand_annealing_(SDSA) abstract "In genetics, the initial processes involved in repair of a double-strand break by synthesis-dependent strand annealing (SDSA) are identical to those in the double Holliday junction model, and have been most extensively studied in yeast species Saccharomyces cerevisiae. Following a double-stranded break, a protein complex (MRX) binds to either end of the break, working with DNA nucleases to carry out resection, resulting in 5’ end digest to produce 3’ overhangs of single-stranded DNA (see Figure). These overhangs are then bound to form a nucleoprotein filament, which can then locate DNA sequences similar to one of the 3’ overhangs, initiating a single-stranded strand invasion into the DNA duplex containing these sequences. Once strand invasion has occurred, a displacement loop, or D-loop, is formed, at which point either SDSA or a double Holliday junction occurs.Homologous recombination via the SDSA pathway occurs in both mitotic and meiotic cells as an important mechanism of non-crossover recombination, and was first suggested as a model in 1976, acquiring its current name in 1994. As the double Holliday junction model was the first posited in order to explain this phenomenon, various versions of the SDSA model were later proposed to explain heteroduplex DNA configurations that did not match predictions of the double Holliday junction model. Studies in S. cerevisiae found that non-crossover products appear earlier than double Holliday junctions or crossover products, which challenged the previous notion that both crossover and non-crossover products are produced by double Holliday junctions.In the SDSA model, repair of double-stranded breaks occurs without the formation of a double Holliday junction, such that the two processes of homologous recombination are identical until just after D-loop formation. In yeast, the D-loop is formed by strand invasion with the help of proteins Rad51 and Rad52, and is then acted on by DNA helicase Srs2 to prevent formation of the double Holliday junction in order for the SDSA pathway to occur. The invading 3’ strand is thus extended along the recipient homologous DNA duplex by DNA polymerase in the 5’ to 3’ direction, such that the D-loop physically translocates – a process referred to as bubble migration DNA synthesis. The resulting single Holliday junction then slides down the DNA duplex in the same direction in a process called branch migration, displacing the extended strand from the template strand. This displaced strand pops up to form a 3’ overhang in the original double-stranded break duplex, which can then anneal to the opposite end of the original break through complementary base pairing. Thus DNA synthesis fills in gaps left over from annealing, and extends both ends of the still present single stranded DNA break, ligating all remaining gaps to produce recombinant non-crossover DNA.SDSA is unique in that D-loop translocation results in conservative rather than semiconservative replication, as the first extended strand is displaced from its template strand, leaving the homologous duplex intact. Therefore, it should be noted that while SDSA produces non-crossover products because flanking markers of heteroduplex DNA are not exchanged, gene conversion does occur, wherein nonreciprocal genetic transfer takes place between two homologous sequences.".
- Synthesis-dependent_strand_annealing_(SDSA) thumbnail Homologous_Recombination.jpg?width=300.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageID "37890211".
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageLength "12097".
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageOutDegree "50".
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageRevisionID "695886914".
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Arabidopsis_thaliana.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Bloom_syndrome_protein.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Branch_migration.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Caenorhabditis_elegans.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Category:Genetics.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Chromosomal_crossover.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Complementarity_(molecular_biology).
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink D-loop.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink DMC1_(gene).
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink DNA_ligase.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink DNA_polymerase.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink DNA_repair.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Drosophila_melanogaster.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Gene_conversion.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Genetic_recombination.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Genetics.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Helicase.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Heteroduplex.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Holliday_junction.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Homologous_chromosome.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Homologous_recombination.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Homology_(biology).
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink MRX_complex.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Meiosis.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Nuclease.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Nucleic_acid_thermodynamics.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Nucleoprotein.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Podospora_anserina.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink RAD51.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink RAD52.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink RMI1.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink RecA.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Replication_protein_A.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Saccharomyces_cerevisiae.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Semiconservative_replication.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Sordaria_fimicola.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink TOP3A.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink Transcription_(genetics).
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLink File:Homologous_Recombination.jpg.
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLinkText "Synthesis-dependent strand annealing (SDSA)".
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLinkText "non-crossover".
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageWikiLinkText "synthesis-dependent strand annealing".
- Synthesis-dependent_strand_annealing_(SDSA) wikiPageUsesTemplate Template:Reflist.
- Synthesis-dependent_strand_annealing_(SDSA) subject Category:Genetics.
- Synthesis-dependent_strand_annealing_(SDSA) comment "In genetics, the initial processes involved in repair of a double-strand break by synthesis-dependent strand annealing (SDSA) are identical to those in the double Holliday junction model, and have been most extensively studied in yeast species Saccharomyces cerevisiae.".
- Synthesis-dependent_strand_annealing_(SDSA) label "Synthesis-dependent strand annealing (SDSA)".
- Synthesis-dependent_strand_annealing_(SDSA) sameAs Q7662703.
- Synthesis-dependent_strand_annealing_(SDSA) sameAs m.0pcltxx.
- Synthesis-dependent_strand_annealing_(SDSA) sameAs Q7662703.
- Synthesis-dependent_strand_annealing_(SDSA) wasDerivedFrom Synthesis-dependent_strand_annealing_(SDSA)?oldid=695886914.
- Synthesis-dependent_strand_annealing_(SDSA) depiction Homologous_Recombination.jpg.
- Synthesis-dependent_strand_annealing_(SDSA) isPrimaryTopicOf Synthesis-dependent_strand_annealing_(SDSA).