Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/NUMB_(gene)> ?p ?o }
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- NUMB_(gene) abstract "Protein numb homolog is a protein that in humans is encoded by the NUMB gene.The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.The protein Numb is coded for by the gene, NUMB, whose mechanism appears to be evolutionarily conserved. Numb has been extensively studied in both invertebrates and mammals, though its function is best understood in Drosophila. Numb plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. During neurogenesis, Numb localizes to one side of the mother cell such that it is distributed selectively to one daughter cell. This asymmetric division allows a daughter cell containing Numb to acquire a different fate than the other daughter cell.".
- NUMB_(gene) entrezgene "8650".
- NUMB_(gene) wikiPageID "14181897".
- NUMB_(gene) wikiPageLength "31670".
- NUMB_(gene) wikiPageOutDegree "66".
- NUMB_(gene) wikiPageRevisionID "678980463".
- NUMB_(gene) wikiPageWikiLink Adaptor-related_protein_complex_2,_alpha_1.
- NUMB_(gene) wikiPageWikiLink Alternative_splicing.
- NUMB_(gene) wikiPageWikiLink Apoptosis.
- NUMB_(gene) wikiPageWikiLink Asymmetric_cell_division.
- NUMB_(gene) wikiPageWikiLink Asymmetrical_cell_division.
- NUMB_(gene) wikiPageWikiLink Brain-derived_neurotrophic_factor.
- NUMB_(gene) wikiPageWikiLink Breast_cancer.
- NUMB_(gene) wikiPageWikiLink Cell_cycle.
- NUMB_(gene) wikiPageWikiLink Chemotactic.
- NUMB_(gene) wikiPageWikiLink Chemotaxis.
- NUMB_(gene) wikiPageWikiLink Chronic_myelogenous_leukemia.
- NUMB_(gene) wikiPageWikiLink Conserved_sequence.
- NUMB_(gene) wikiPageWikiLink Cytoplasm.
- NUMB_(gene) wikiPageWikiLink DLL4.
- NUMB_(gene) wikiPageWikiLink DPYSL2.
- NUMB_(gene) wikiPageWikiLink Drosophila.
- NUMB_(gene) wikiPageWikiLink Drosophila_melanogaster.
- NUMB_(gene) wikiPageWikiLink EP300.
- NUMB_(gene) wikiPageWikiLink EPS15.
- NUMB_(gene) wikiPageWikiLink Endocytosis.
- NUMB_(gene) wikiPageWikiLink Evolutionarily_conserved.
- NUMB_(gene) wikiPageWikiLink Ganglion_mother_cell.
- NUMB_(gene) wikiPageWikiLink Gene.
- NUMB_(gene) wikiPageWikiLink Histone_acetyltransferase.
- NUMB_(gene) wikiPageWikiLink Integral_membrane_protein.
- NUMB_(gene) wikiPageWikiLink JAG1.
- NUMB_(gene) wikiPageWikiLink JAG2.
- NUMB_(gene) wikiPageWikiLink L1_(protein).
- NUMB_(gene) wikiPageWikiLink LNX1.
- NUMB_(gene) wikiPageWikiLink MDM2.
- NUMB_(gene) wikiPageWikiLink Mammary_carcinoma.
- NUMB_(gene) wikiPageWikiLink Mdm2.
- NUMB_(gene) wikiPageWikiLink NOTCH1.
- NUMB_(gene) wikiPageWikiLink NUMBL.
- NUMB_(gene) wikiPageWikiLink Neuroblast.
- NUMB_(gene) wikiPageWikiLink Neurogenesis.
- NUMB_(gene) wikiPageWikiLink Non-small-cell_lung_carcinoma.
- NUMB_(gene) wikiPageWikiLink Notch_1.
- NUMB_(gene) wikiPageWikiLink Notch_signaling_pathway.
- NUMB_(gene) wikiPageWikiLink Oncogene.
- NUMB_(gene) wikiPageWikiLink P53.
- NUMB_(gene) wikiPageWikiLink Phosphorylate.
- NUMB_(gene) wikiPageWikiLink Phosphorylation.
- NUMB_(gene) wikiPageWikiLink Phosphotyrosine-binding_domain.
- NUMB_(gene) wikiPageWikiLink Proteasome.
- NUMB_(gene) wikiPageWikiLink Protein.
- NUMB_(gene) wikiPageWikiLink Protein-protein_interaction.
- NUMB_(gene) wikiPageWikiLink Protein–protein_interaction.
- NUMB_(gene) wikiPageWikiLink Receptor_antagonist.
- NUMB_(gene) wikiPageWikiLink SIAH1.
- NUMB_(gene) wikiPageWikiLink Salivary_gland_neoplasm.
- NUMB_(gene) wikiPageWikiLink TP53.
- NUMB_(gene) wikiPageWikiLink TrkB_receptor.
- NUMB_(gene) wikiPageWikiLink Tropomyosin_receptor_kinase_B.
- NUMB_(gene) wikiPageWikiLink Ubiquitin.
- NUMB_(gene) wikiPageWikiLink Ubiquitin_ligase.
- NUMB_(gene) wikiPageWikiLinkText "NUMB (gene)".
- NUMB_(gene) wikiPageWikiLinkText "NUMB".
- NUMB_(gene) wikiPageWikiLinkText "Notch-binding protein".
- NUMB_(gene) wikiPageWikiLinkText "Numb".
- NUMB_(gene) hasPhotoCollection NUMB_(gene).
- NUMB_(gene) wikiPageUsesTemplate Template:Cite_journal.
- NUMB_(gene) wikiPageUsesTemplate Template:PBB.
- NUMB_(gene) wikiPageUsesTemplate Template:Refbegin.
- NUMB_(gene) wikiPageUsesTemplate Template:Refend.
- NUMB_(gene) wikiPageUsesTemplate Template:Reflist.
- NUMB_(gene) hypernym Protein.
- NUMB_(gene) type Biomolecule.
- NUMB_(gene) type Protein.
- NUMB_(gene) type Thing.
- NUMB_(gene) type Q206229.
- NUMB_(gene) type Q8054.
- NUMB_(gene) comment "Protein numb homolog is a protein that in humans is encoded by the NUMB gene.The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1.".
- NUMB_(gene) label "NUMB (gene)".
- NUMB_(gene) sameAs NUMB.
- NUMB_(gene) sameAs m.03cx372.
- NUMB_(gene) sameAs Q6955601.
- NUMB_(gene) sameAs Q6955601.
- NUMB_(gene) wasDerivedFrom NUMB_(gene)?oldid=678980463.
- NUMB_(gene) isPrimaryTopicOf NUMB_(gene).