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- FLAG_(chemotherapy) abstract "FLAG in the context of chemotherapy means an acronym for a chemotherapy regimen used for relapsed or refractory acute myelogenous leukemia.The FLAG regimen consists of: (FL)udarabine - an antimetabolite that is not active itself in AML, but it increases the formation of an active cytarabine metabolite, ara-CTP, in AML cells; High-dose (A)ra-C - an antimetabolite that has proven to be the most active in AML among various cytotoxic drugs in single-drug trials; Granulocyte colony-stimulating factor - (G)-CSF to shorten the duration and severity of neutropenia.The FLAG and FLAG-based regimens can also be used in cases where there are concomitant AML and acute lymphoblastic leukemia, or AML and lymphoma, or in cases of so-called "biphenotypic" AML (where the cells display properties of both myeloid and lymphoid cells), since fludarabine is highly active in lymphoid malignancies.There are also several intensified versions, in which a third chemotherapeutic agent is added:FLAG-IDA or FLAG-Ida or IDA-FLAG or Ida-FLAG is a FLAG-based regimen with idarubicin added, i.e.: (FL)udarabine; High-dose (A)ra-C; Granulocyte colony-stimulating factor - (G)-CSF; (IDA)rubicin - an anthracycline antibiotic that is able to intercalate DNA and prevent cell division (mitosis).Mito-FLAG or MITO-FLAG or FLAG-MITO or FLAG-Mito is another FLAG-based regimen with mitoxantrone added, i.e.: (FL)udarabine; High-dose (A)ra-C; Granulocyte colony-stimulating factor - (G)-CSF; (Mito)xantrone - a synthetic anthracycline analogue (an anthracenedione) that is able to intercalate DNA and prevent cell division (mitosis).FLAMSA is another one FLAG-based regimen with amsacrine added, i.e.: (FL)udarabine; High-dose (A)ra-C; Granulocyte colony-stimulating factor - G-CSF; (AMSA)crine - an alkylating antineoplastic agent that is, unlike more conventional alkylators, e.g. cyclophosphamide, highly active in AML.The FLAMSA protocol is most often used as an induction part of a reduced-intensity pre-transplant conditioning regimen for patients eligible to undergo an allogeneic stem cell transplant. In this setting, it is often combined with cyclophosphamide (FLAMSA-CYC) and/or busulfan or treosulfan (FLAMSA-BU or FLAMSA-TREO) and/or melphalan (FLAMSA-MEL) and/or total body irradiation given shortly after the end of FLAMSA, to prepare the patient for transplant.".
- FLAG_(chemotherapy) wikiPageID "43823423".
- FLAG_(chemotherapy) wikiPageLength "10160".
- FLAG_(chemotherapy) wikiPageOutDegree "70".
- FLAG_(chemotherapy) wikiPageRevisionID "678800943".
- FLAG_(chemotherapy) wikiPageWikiLink Acronym.
- FLAG_(chemotherapy) wikiPageWikiLink Acute_lymphoblastic_leukemia.
- FLAG_(chemotherapy) wikiPageWikiLink Acute_myelogenous_leukemia.
- FLAG_(chemotherapy) wikiPageWikiLink Acute_myeloid_leukemia.
- FLAG_(chemotherapy) wikiPageWikiLink Alkylating_antineoplastic_agent.
- FLAG_(chemotherapy) wikiPageWikiLink Amsacrine.
- FLAG_(chemotherapy) wikiPageWikiLink Anthracenedione.
- FLAG_(chemotherapy) wikiPageWikiLink Anthracycline.
- FLAG_(chemotherapy) wikiPageWikiLink Anthraquinone.
- FLAG_(chemotherapy) wikiPageWikiLink Antibiotic.
- FLAG_(chemotherapy) wikiPageWikiLink Antibiotics.
- FLAG_(chemotherapy) wikiPageWikiLink Antimetabolite.
- FLAG_(chemotherapy) wikiPageWikiLink Busulfan.
- FLAG_(chemotherapy) wikiPageWikiLink Category:Chemotherapy_regimens_used_in_acute_myeloid_leukemia.
- FLAG_(chemotherapy) wikiPageWikiLink Cell_division.
- FLAG_(chemotherapy) wikiPageWikiLink Chemotherapy.
- FLAG_(chemotherapy) wikiPageWikiLink Chemotherapy_regimen.
- FLAG_(chemotherapy) wikiPageWikiLink Cyclophosphamide.
- FLAG_(chemotherapy) wikiPageWikiLink Cytarabine.
- FLAG_(chemotherapy) wikiPageWikiLink DNA.
- FLAG_(chemotherapy) wikiPageWikiLink Filgrastim.
- FLAG_(chemotherapy) wikiPageWikiLink Fludarabine.
- FLAG_(chemotherapy) wikiPageWikiLink G-CSF.
- FLAG_(chemotherapy) wikiPageWikiLink Granulocyte_colony-stimulating_factor.
- FLAG_(chemotherapy) wikiPageWikiLink Hematopoietic_stem_cell_transplantation.
- FLAG_(chemotherapy) wikiPageWikiLink Idarubicin.
- FLAG_(chemotherapy) wikiPageWikiLink Intercalation_(biochemistry).
- FLAG_(chemotherapy) wikiPageWikiLink Lymphoma.
- FLAG_(chemotherapy) wikiPageWikiLink Melphalan.
- FLAG_(chemotherapy) wikiPageWikiLink Melting.
- FLAG_(chemotherapy) wikiPageWikiLink Mitosis.
- FLAG_(chemotherapy) wikiPageWikiLink Mitoxantrone.
- FLAG_(chemotherapy) wikiPageWikiLink Neutropenia.
- FLAG_(chemotherapy) wikiPageWikiLink Refractoriness.
- FLAG_(chemotherapy) wikiPageWikiLink Relapse.
- FLAG_(chemotherapy) wikiPageWikiLink Stem_cell_transplant.
- FLAG_(chemotherapy) wikiPageWikiLink Total_body_irradiation.
- FLAG_(chemotherapy) wikiPageWikiLink Treosulfan.
- FLAG_(chemotherapy) wikiPageWikiLinkText "FLAG (chemotherapy)".
- FLAG_(chemotherapy) wikiPageWikiLinkText "FLAG".
- FLAG_(chemotherapy) wikiPageWikiLinkText "FLAG-like regimens".
- FLAG_(chemotherapy) date "March 2015".
- FLAG_(chemotherapy) for "style".
- FLAG_(chemotherapy) hasPhotoCollection FLAG_(chemotherapy).
- FLAG_(chemotherapy) wikiPageUsesTemplate Template:Copy_edit.
- FLAG_(chemotherapy) wikiPageUsesTemplate Template:Reflist.
- FLAG_(chemotherapy) subject Category:Chemotherapy_regimens_used_in_acute_myeloid_leukemia.
- FLAG_(chemotherapy) hypernym AML.
- FLAG_(chemotherapy) comment "FLAG in the context of chemotherapy means an acronym for a chemotherapy regimen used for relapsed or refractory acute myelogenous leukemia.The FLAG regimen consists of: (FL)udarabine - an antimetabolite that is not active itself in AML, but it increases the formation of an active cytarabine metabolite, ara-CTP, in AML cells; High-dose (A)ra-C - an antimetabolite that has proven to be the most active in AML among various cytotoxic drugs in single-drug trials; Granulocyte colony-stimulating factor - (G)-CSF to shorten the duration and severity of neutropenia.The FLAG and FLAG-based regimens can also be used in cases where there are concomitant AML and acute lymphoblastic leukemia, or AML and lymphoma, or in cases of so-called "biphenotypic" AML (where the cells display properties of both myeloid and lymphoid cells), since fludarabine is highly active in lymphoid malignancies.There are also several intensified versions, in which a third chemotherapeutic agent is added:FLAG-IDA or FLAG-Ida or IDA-FLAG or Ida-FLAG is a FLAG-based regimen with idarubicin added, i.e.: (FL)udarabine; High-dose (A)ra-C; Granulocyte colony-stimulating factor - (G)-CSF; (IDA)rubicin - an anthracycline antibiotic that is able to intercalate DNA and prevent cell division (mitosis).Mito-FLAG or MITO-FLAG or FLAG-MITO or FLAG-Mito is another FLAG-based regimen with mitoxantrone added, i.e.: (FL)udarabine; High-dose (A)ra-C; Granulocyte colony-stimulating factor - (G)-CSF; (Mito)xantrone - a synthetic anthracycline analogue (an anthracenedione) that is able to intercalate DNA and prevent cell division (mitosis).FLAMSA is another one FLAG-based regimen with amsacrine added, i.e.: (FL)udarabine; High-dose (A)ra-C; Granulocyte colony-stimulating factor - G-CSF; (AMSA)crine - an alkylating antineoplastic agent that is, unlike more conventional alkylators, e.g. ".
- FLAG_(chemotherapy) label "FLAG (chemotherapy)".
- FLAG_(chemotherapy) sameAs m.011v5w7s.
- FLAG_(chemotherapy) sameAs FLAG_(химиотерапия).
- FLAG_(chemotherapy) sameAs Q18043324.
- FLAG_(chemotherapy) sameAs Q18043324.
- FLAG_(chemotherapy) wasDerivedFrom FLAG_(chemotherapy)?oldid=678800943.
- FLAG_(chemotherapy) isPrimaryTopicOf FLAG_(chemotherapy).