Matches in DBpedia 2015-10 for { ?s ?p "Considering the importance of NAD+ in energy metabolism, DNA repair and transcriptional regulation, maintaining intracellular NAD+ reserves emerges as a major therapeutic target for the treatment of several age-related degenerative diseases, including Alzheimer's disease (Belenky et al., 2007). In particular, increased nuclear NAD+ biosynthesis and consequent activation of SIRT1 has been shown to protect mouse neurons from mechanical and chemical injury (Bedalov and Simon, 2004)."@en }
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- NAD+_in_neurodegeneration comment "Considering the importance of NAD+ in energy metabolism, DNA repair and transcriptional regulation, maintaining intracellular NAD+ reserves emerges as a major therapeutic target for the treatment of several age-related degenerative diseases, including Alzheimer's disease (Belenky et al., 2007). In particular, increased nuclear NAD+ biosynthesis and consequent activation of SIRT1 has been shown to protect mouse neurons from mechanical and chemical injury (Bedalov and Simon, 2004).".