Matches in DBpedia 2015-10 for { ?s ?p "Acute myelomonocytic leukemia (AMMoL) is a form of acute myeloid leukemia that involves a proliferation of CFU-GM myeloblasts and monoblasts.It is classified under "M4" in the French-American-British classification (FAB).It is classified under "AML, not otherwise classified" in the WHO classification.Translocations have been observed.Progression from myelodysplastic syndrome has been reported.Acute myeloblastic leukemia (AML) is a group of malignant bone marrow neoplasms of myeloidprecursors of white blood cells. Acute myelomonocytic leukemia (AML-M4) is a common type of pediatric AML. However, the condition is rare and represents approximately 3 % of all leukemias during childhood and has an incidence of 1.1 – 1.7 per million per year. The symptoms may be aspecific: asthenia, pallor, fever, dizziness and respiratory symptoms. More specific symptoms are bruises and/or (excessive)bleeding, coagulation disorders (DIC), neurological disorders and gingival hyperplasia. Diagnosticmethods include blood analysis, bone marrow aspirate for cytochemical, immunological and cytogeneticalanalysis, and cerebrospinal fluid (CSF) investigations. A characteristic chromosomal abnormalityobserved in AML-M4 is inv(16). Treatment includes intensive multidrug chemotherapy and in selected cases allogeneic bone marrow transplantation. Nevertheless, outcome of AML remains poor with anoverall survival of 35-60%. Children with AML-M4 carrying the inv(16) abnormality have a better prognosis (61% 5-year overall survival). New therapeutics are required to increase the probability of cure in this serious disorder."@en }
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- Acute_myelomonocytic_leukemia abstract "Acute myelomonocytic leukemia (AMMoL) is a form of acute myeloid leukemia that involves a proliferation of CFU-GM myeloblasts and monoblasts.It is classified under "M4" in the French-American-British classification (FAB).It is classified under "AML, not otherwise classified" in the WHO classification.Translocations have been observed.Progression from myelodysplastic syndrome has been reported.Acute myeloblastic leukemia (AML) is a group of malignant bone marrow neoplasms of myeloidprecursors of white blood cells. Acute myelomonocytic leukemia (AML-M4) is a common type of pediatric AML. However, the condition is rare and represents approximately 3 % of all leukemias during childhood and has an incidence of 1.1 – 1.7 per million per year. The symptoms may be aspecific: asthenia, pallor, fever, dizziness and respiratory symptoms. More specific symptoms are bruises and/or (excessive)bleeding, coagulation disorders (DIC), neurological disorders and gingival hyperplasia. Diagnosticmethods include blood analysis, bone marrow aspirate for cytochemical, immunological and cytogeneticalanalysis, and cerebrospinal fluid (CSF) investigations. A characteristic chromosomal abnormalityobserved in AML-M4 is inv(16). Treatment includes intensive multidrug chemotherapy and in selected cases allogeneic bone marrow transplantation. Nevertheless, outcome of AML remains poor with anoverall survival of 35-60%. Children with AML-M4 carrying the inv(16) abnormality have a better prognosis (61% 5-year overall survival). New therapeutics are required to increase the probability of cure in this serious disorder.".