Matches in DBpedia 2015-10 for { ?s ?p "βTrCP2 (also known as Fbxw11 or HOS) is a protein that in humans is encoded by the BTRC (beta-transducin repeat containing) gene.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 residue structural motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (Skp1-Cul1-F-box protein), which often, but not always, recognize substrates in a phosphorylation-dependent manner. F-box proteins are divided into 3 classes: Fbxws containing WD40 repeats, Fbxls containing leucine-rich repeats, and Fbxos containing either "other" protein-protein interaction modules or no recognizable motifs.The protein encoded by FBXW11 belongs to the Fbxw class as, in addition to an F-box, this protein contains multiple WD40 repeats. This protein is homologous to Xenopus βTrCP, yeast Met30, Neurospora Scon2 and Drosophila Slimb. In mammals, in addition to βTrCP2, a paralog protein (called βTrCP1 or FBXW11) also exists, but, so far, their functions appear redundant and indistinguishable."@en }
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- FBXW11 abstract "βTrCP2 (also known as Fbxw11 or HOS) is a protein that in humans is encoded by the BTRC (beta-transducin repeat containing) gene.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 residue structural motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (Skp1-Cul1-F-box protein), which often, but not always, recognize substrates in a phosphorylation-dependent manner. F-box proteins are divided into 3 classes: Fbxws containing WD40 repeats, Fbxls containing leucine-rich repeats, and Fbxos containing either "other" protein-protein interaction modules or no recognizable motifs.The protein encoded by FBXW11 belongs to the Fbxw class as, in addition to an F-box, this protein contains multiple WD40 repeats. This protein is homologous to Xenopus βTrCP, yeast Met30, Neurospora Scon2 and Drosophila Slimb. In mammals, in addition to βTrCP2, a paralog protein (called βTrCP1 or FBXW11) also exists, but, so far, their functions appear redundant and indistinguishable.".