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- Q868658 subject Q20870725.
- Q868658 subject Q7071513.
- Q868658 subject Q7335370.
- Q868658 subject Q8182050.
- Q868658 subject Q8788974.
- Q868658 abstract "Perampanel (INN/USAN, trade name Fycompa) is an antiepileptic drug developed by Eisai Co. that acts as a selective non-competitive antagonist of AMPA receptors, the major subtype of ionotropic glutamate receptors.Perampanel was found to be effective in the treatment of refractory partial-onset seizures in three pivotal (Phase 3) clinical trials and has been approved for marketing under the brand name Fycompa by the European Medicines Agency. The minimum effective dose is 4 mg once daily; doses of 8 mg and 12 mg daily provide a greater therapeutic benefit with a corresponding increase in adverse events. Dizziness and somnolence/sedation/fatigue are the most frequent dose-related adverse events. The drug is currently approved, for the control of partial-onset seizures, in those of both sexes who suffer from epilepsy and who are 12 years of age and older, by the Food and Drug Administration. Perampanel is also approved for the treatment of primary generalized tonic-clonic seizures in patients with epilepsy aged 12 years and older. It is designated as a Schedule III controlled substance by the Drug Enforcement Administration. Perampanel has been studied in other clinical indications including Parkinson's disease.".
- Q868658 atcPrefix "N03".
- Q868658 atcSuffix "AX22".
- Q868658 bioavailability "116.0".
- Q868658 casNumber "380917-97-5".
- Q868658 chEBI "71013".
- Q868658 fdaUniiCode "H821664NPK".
- Q868658 iupacName "5'-(2-cyanophenyl)-1'-phenyl-2,3'-bipyridinyl-6'(1'H)-one".
- Q868658 pubchem "9924495".
- Q868658 thumbnail Perampanel_structure.svg?width=300.
- Q868658 wikiPageWikiLink Q1077823.
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- Q868658 wikiPageWikiLink Q622899.
- Q868658 wikiPageWikiLink Q633403.
- Q868658 wikiPageWikiLink Q6596470.
- Q868658 wikiPageWikiLink Q7071513.
- Q868658 wikiPageWikiLink Q7335370.
- Q868658 wikiPageWikiLink Q751641.
- Q868658 wikiPageWikiLink Q7678869.
- Q868658 wikiPageWikiLink Q7708612.
- Q868658 wikiPageWikiLink Q8182050.
- Q868658 wikiPageWikiLink Q824258.
- Q868658 wikiPageWikiLink Q827017.
- Q868658 wikiPageWikiLink Q8386.
- Q868658 wikiPageWikiLink Q8788974.
- Q868658 wikiPageWikiLink Q903384.
- Q868658 wikiPageWikiLink Q9690.
- Q868658 atcPrefix "N03".
- Q868658 atcSuffix "AX22".
- Q868658 bioavailability "116.0".
- Q868658 casNumber "380917".
- Q868658 chebi "71013".
- Q868658 iupacName "5".
- Q868658 pubchem "9924495".
- Q868658 unii "H821664NPK".
- Q868658 type ChemicalSubstance.
- Q868658 type Drug.
- Q868658 type ChemicalObject.
- Q868658 type Thing.
- Q868658 type Q8386.
- Q868658 comment "Perampanel (INN/USAN, trade name Fycompa) is an antiepileptic drug developed by Eisai Co. that acts as a selective non-competitive antagonist of AMPA receptors, the major subtype of ionotropic glutamate receptors.Perampanel was found to be effective in the treatment of refractory partial-onset seizures in three pivotal (Phase 3) clinical trials and has been approved for marketing under the brand name Fycompa by the European Medicines Agency.".
- Q868658 label "Perampanel".
- Q868658 depiction Perampanel_structure.svg.